ABSTRACT
We present the first demonstration of mid-IR supercontinuum generation directly pumped with picosecond pulses from a Thulium fiber-amplified gain-switched laser diode at 2 µm. We achieve more than two octaves of bandwidth from 750 - 4000 nm in step-index ZBLAN fiber with Watt-level average power and spectral flatness of less than 1.5 dB over a 1300 nm range in the mid-IR from 2450 - 3750 nm. The system offers high stability, power-scaling capability to the 10 W regime, and demonstrates an attractive route towards relatively inexpensive, versatile and practical sources of high power broadband mid-IR radiation.
ABSTRACT
Urinary prostaglandin E and F (PGE and PGF) concentrations, renal plasma flow (RPF), glomerular filtration rate (GFR), sodium excretion rate (UNaV), potassium excretion rate (UKV), urinary osmolarity (Uosm) and osmolar clearance (Cosm) were found to be higher, while mean blood pressure (MBP) was lower in a group of 15 normotensive subjects (15NS), compared to those values obtained in a group of 25 essential patients (25EHP) of the same mean age. After volume expansion, of the 25EHP, urinary PGE concentration, RPF, noncortical plasma flow (NCPF), UNaV, UKV, UNaV/UKV, Cosm and urine volume (UV) increased significantly, MBP, GFR, Uosm, free water reabsorption (Tc water) and urinary aldosterone concentration did not change, while plasma renin activity (PRA) decreased significantly. It was concluded that the deficiency in renomedullary PG synthesis in the EHP is accompanied by a decrease in RPF, NCPF and UNaV. This decrease in UNaV and renal hemodynamics could increase, in the long term, the BP in these patients. Nevertheless, these findings do not exclude the interpretation that the decrease in renomedullary PGE release in the EHP indicates an attempt to increase sodium excretion at the distal tubule by diminishing sodium reabsorption by this agent in order to prevent further increase in BP. In any case, it seems that renomedullary PGs play an important role in intra-renal control systems.
