ABSTRACT
BACKGROUND: Multiple studies have evaluated diverse allergens in paediatric populations. Consensus is still lacking on which allergens are most commonly implicated in allergic contact dermatitis. OBJECTIVES: To evaluate the proportion of positive reactions for allergens tested in children and to identify allergens with positive reactions in at least 1% of them. METHODS: This was a systematic review of studies in PubMed (1966-2010) investigating allergens in at least 100 enrolled children. Proportions of positive reactions for each allergen were combined with random effects models across studies. RESULTS: We included 49 studies with available data on 170 allergens. Each study tested a median of two allergens. Among the 94 allergens evaluated by at least two studies, 58 had estimates of positive reactions of at least 1% by random effects calculations, and for 21 of them the 95% confidence interval ensured that the proportion of positive reactions was at least 1%. The top five allergens tested by at least two studies included nickel sulfate, ammonium persulfate, gold sodium thiosulfate, thimerosal, and toluene-2,5-diamine (p-toluenediamine). For most allergens, the proportion of positive reactions was higher in studies published after 1995 than in earlier studies (p = 0.0065). CONCLUSIONS: This meta-analysis offers guidance on which allergens are most prevalent in the paediatric population and should have priority for inclusion in standardized allergen series.
Subject(s)
Allergens/adverse effects , Dermatitis, Allergic Contact/etiology , Allergens/immunology , Child , Humans , Patch TestsSubject(s)
Prurigo/etiology , Prurigo/pathology , Skin/pathology , Tonsillitis/complications , Adult , Chronic Disease , Humans , Male , RecurrenceABSTRACT
INTRODUCTION: Prurigo nodularis is an unusual disorder of unknown aetiology, which is notoriously resistant to therapy, and is characterized by extremely pruritic nodules with well-defined clinical symptoms and histopathological findings. CASE PRESENTATION: We report the case of a patient presenting with pruritic papules and nodules on his legs, arms and trunk over the past 4 years, recurring after episodes of acute tonsillitis. Although oral and topical corticosteroids, oral antibiotics and emollients were used in his therapy, only tonsillectomy finally proved the definitive treatment. CONCLUSION: We discuss the aetiopathogenesis, diagnosis and treatment of prurigo nodularis associated with chronic tonsillitis, and we further review the literature on this rare condition.
ABSTRACT
Cutaneous metastases from breast adenocarcinoma are usually nodular, single or multiple. Their zosteriform distribution is very rare. We present a 54-year-old woman with cutaneous zosteriform nodular metastases on the right side of her thorax, and infiltration of the corresponding arm, 3 months after the excision of adenocarcinoma of her right breast.
Subject(s)
Adenocarcinoma/secondary , Adenocarcinoma/surgery , Breast Neoplasms/surgery , Herpes Zoster/pathology , Skin Neoplasms/secondary , Biopsy, Needle , Breast Neoplasms/pathology , Female , Follow-Up Studies , Humans , Immunohistochemistry , Mastectomy, Radical/methods , Middle Aged , Neoplasm Staging , Risk Assessment , Skin Neoplasms/pathologyABSTRACT
A 76-year-old woman with atypical hemorrhagic Kaposi sarcoma is presented. The patient was treated with recombinant interferon alpha-2b (3,000,000 IU) subcutaneously, three times weekly for 6 months and twice weekly as maintenance dose for 14 months with excellent response and no recurrence after a 7 years of follow-up.
Subject(s)
Interferon-alpha/administration & dosage , Sarcoma, Kaposi/drug therapy , Sarcoma, Kaposi/pathology , Skin Neoplasms/drug therapy , Skin Neoplasms/pathology , Aged , Biopsy, Needle , Dose-Response Relationship, Drug , Drug Administration Schedule , Female , Follow-Up Studies , Hemorrhage/drug therapy , Hemorrhage/pathology , Humans , Immunohistochemistry , Injections, Subcutaneous , Interferon alpha-2 , Recombinant Proteins , Risk Assessment , Treatment OutcomeABSTRACT
We present a 72-year-old man with a subungual amelanotic malignant melanoma (MM) on the right first toe with numerous local nodular metastases after trauma and without regional lymph node involvement. Most of the lesions were angiomatous (reddish blue), and some had a hyperkeratotic surface, clinically resembling Kaposi sarcoma. Results of biopsies performed on skin taken from the toe and from a metastatic lesion of the tibia revealed a classic case of amelanotic MM. This case has 2 interesting points: the clinical presentation of the metastatic lesions and the topical spreading of the lesions, which was initiated after traumatic injury of the prime lesion.
