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1.
Ann Neurol ; 8(6): 625-7, 1980 Dec.
Article in English | MEDLINE | ID: mdl-7212651

ABSTRACT

Measles virus nucleotide sequences were searched for in diseased and normal-appearing white matter from brains of four multiple sclerosis victims. At the level of sensitivity established, 2.5 to 7.8 measles virus genome-equivalents of RNA, or 4.9 genome-equivalents of putative DNA per diploid cell quantity of DNA, could have been detected. At these levels, no measles virus genetic information was found in any of the four brains.


Subject(s)
Brain Chemistry , DNA, Viral/analysis , Measles virus/genetics , Multiple Sclerosis/genetics , RNA, Viral/analysis , Adult , Aged , Female , Humans , Male , Middle Aged , Nucleic Acid Hybridization
2.
Infect Immun ; 9(5): 946-51, 1974 May.
Article in English | MEDLINE | ID: mdl-4363236

ABSTRACT

The cell type(s) harboring latent herpes simplex virus in the spinal ganglia of mice was investigated. Taken together, results from immunofluorescence, electron microscopic, autoradiographic, and in situ nucleic acid hybridization methods suggest strongly that, in mice, latent virus is maintained in neurons.


Subject(s)
Ganglia, Spinal/microbiology , Herpes Simplex/immunology , Neurons/microbiology , Simplexvirus/isolation & purification , Animals , Autoradiography , Carrier State , Culture Techniques , Fluorescent Antibody Technique , Ganglia, Spinal/immunology , Mice , Microscopy, Electron , Nucleic Acid Hybridization , Tritium , Virus Cultivation
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