ABSTRACT
A systematic review was carried out to study the pattern of high-sensitivity cardiac troponin release after running (search performed on PubMed, ISI Web of Knowledge and Scopus databases). A total of ten reports were identified as meeting the pre-specified criteria (eight using high-sensitivity troponin T and two using high-sensitivity troponin I). The papers were published between 2009 and 2013, amounting to a total of 479 participants under study. Eight reports provided data comparing post-running troponin levels with the 99th percentile reference value. A total number of 296 participants, out of 424, showed post-running high-sensitivity troponin values higher than the 99th percentile reference value (69.8%). In conclusion, using high-sensitivity cardiac troponin assays, studies have shown that elevated post-running values are seen in more than two-thirds of runners. Whether troponin release in this setting represents a fully reversible phenomenon is currently unknown; the effects of strenuous running on long-term health are also uncertain.
Subject(s)
Myocardial Infarction/diagnosis , Running/physiology , Troponin I/blood , Troponin T/blood , Adolescent , Adult , Biomarkers/blood , Diagnostic Techniques, Cardiovascular , Female , Humans , Male , Middle Aged , Myocardial Infarction/blood , Prospective Studies , Qualitative Research , Reference Values , Sensitivity and Specificity , Young AdultABSTRACT
We have characterized the serum lipoprotein profile and localized the serum paraoxonase activity of pacu, Piaractus mesopotamicus, a tropical fish species. The total lipoprotein profile of pacu serum obtained after KBr density ultracentrifugation shows the predominance of HDL (1.1267 g/mL). SDS-PAGE electrophoresis revealed a negligible amount of LDL. Pacu HDL was purified by gel filtration column on HPLC, and its molecular mass was estimated to be 246 kDa. Protein composition was 35%, and comprised four protein components with molecular masses of 45, 38, 25 and 12.5 kDa. Lipids represent 58% of total HDL, comprising 40% neutral lipids and 18% phospholipids by weight. The HDL contains 7% of carbohydrates, and mannose was the only sugar detected by paper chromatography in HDL hydrolysates. HDL-containing fractions showed the major paraoxonase activity. Purification of HDL resulted in a 23-fold enrichment of this activity. This is the first experimental evidence demonstrating the association of paraoxonase activity with a HDL in fish.
Subject(s)
Esterases/metabolism , Lipoproteins, HDL/metabolism , Animals , Aryldialkylphosphatase , Fishes , Lipid Metabolism , Mannose/metabolismSubject(s)
Enzyme Inhibitors/pharmacology , Fishes/metabolism , Glutathione Transferase/drug effects , Liver/drug effects , beta-Naphthoflavone/pharmacology , Analysis of Variance , Animals , Benzene Derivatives/metabolism , Brazil , Cytosol/drug effects , Cytosol/enzymology , Dinitrochlorobenzene/metabolism , Ethacrynic Acid/metabolism , Glutathione Transferase/metabolism , Liver/enzymology , Nitrobenzenes/metabolism , Substrate SpecificitySubject(s)
Brain/drug effects , Cholinesterase Inhibitors/toxicity , Cholinesterases/metabolism , Fishes/metabolism , Insecticides/toxicity , Paraoxon/toxicity , Water Pollutants, Chemical/toxicity , Animals , Brain/enzymology , Brazil , Butyrylcholinesterase/metabolism , Cholinesterases/blood , Environmental MonitoringABSTRACT
The case of a boy aged 4 yrs and 7 months, with isolated pulmonary involvement by Langerhans' cell histiocytosis is reported. The presentation of the disease was a sudden pneumothorax, with no previous signs of respiratory disease. The case was confirmed by S-100 and MT1 antibody staining, and was treated with pulse steroids and several pleural drainages, until the boy died after a large bilateral pneumothorax.
Subject(s)
Histiocytosis, Langerhans-Cell/diagnosis , Lung Diseases/diagnosis , Child, Preschool , Histiocytosis, Langerhans-Cell/complications , Histiocytosis, Langerhans-Cell/pathology , Humans , Lung/diagnostic imaging , Lung/pathology , Lung Diseases/complications , Lung Diseases/pathology , Male , Pneumothorax/etiology , RadiographyABSTRACT
A 30-month-old boy was investigated because of a huge abdominal mass in the right upper abdomen. A computed tomography scan and celiac angiography showed that the tumor involved bilateral lobes of the liver. At first, for this disseminated and "unresectable" tumor we did liver biopsy and hepatic arterial catheterization. Through this catheter we started chemotherapy using THP-Adriamycin and cis-platinum. After three courses of chemotherapy, a second-look operation was performed and trisegmentectomy was done to remove the main tumor and metastases, including the left lobe and the right anterior segment. The trisegmentectomy was performed with success, and the boy's serum alpha-fetoprotein (AFP) remains normal 37 months after the start of treatment, indicating a probable permanent cure. Such cases have rarely been reported in the literature. Our experience in treating this patient would seem to encourage aggressive management of advanced hepatoblastoma in other patients.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Cisplatin/administration & dosage , Doxorubicin/analogs & derivatives , Hemangiosarcoma/therapy , Liver Neoplasms/therapy , Child, Preschool , Cisplatin/therapeutic use , Combined Modality Therapy , Doxorubicin/administration & dosage , Doxorubicin/therapeutic use , Hepatectomy , Humans , Infusions, Intra-Arterial , MaleABSTRACT
1. The major components of hepatic drug biotransformation system were identified in a Brazilian freshwater benthic fish. 2. Cytochrome P-450 difference spectra were obtained adding 0.02 mM phenazine ethosulphate and 2 mM ascorbate to microsomal suspensions. Basal levels of P-450 were high (0.9 nmol/mg of microsomal protein) and were not induced by 3-MC. 3. Microsomal NADPH-cytochrome C reductase activity was determined in presence of 1.3 x 10(-4) M NADPH, 3.3 x 10(-5) M cytochrome C, 1.0 x 10(-4) M EDTA, 66 micrograms of microsomal protein per ml in a 0.3 M Tris-HCl buffer, pH 8.6. Basal levels of NADPH-cytochrome C were 152.7 nmoles/min/mg of microsomal protein.
Subject(s)
Fishes/metabolism , Microsomes, Liver/metabolism , Water Pollutants, Chemical/metabolism , Water Pollutants/metabolism , Animals , Ascorbic Acid/pharmacology , Brazil , Cytochrome P-450 Enzyme System/analysis , Female , Hemoglobins/isolation & purification , Inactivation, Metabolic/physiology , Male , NADPH-Ferrihemoprotein Reductase/metabolism , Phenazines/pharmacology , RatsSubject(s)
Humans , Infant, Newborn , Infant, Premature , Indomethacin , Ductus Arteriosus, Patent , Heart FailureABSTRACT
O autor, depois de introducao em que esclarece como coloca o assunto dentro dos parametros da psicanalise, passa aos argumentos de sua hipotese. Apoiado em mitos, lendas, crencas religiosas e dados historicos, ve a possibilidade de que o conflito de geracoes seja decorrente de uma tensao agressiva entre pais e filhos, tendo sua origem nos sentimentos de odio reprimido que uma geracao tem contra a que ira lhe substituir.Ressalta o fato de que vem dos estudos da etologia o reforco biologico para essa hipotese
