ABSTRACT
The results of the study of the level of pancreatic hormones (insulin, glucagon, C-peptide and trypsin), carried out with the aim of finding out the character of relationship between hormonal disturbances and the state of carbohydrate metabolism, as well as the influence of oral rehydration therapy (ORT) with glucose-salt solutions on the function of the pancreas, are summarized. All subjects to be examined were divided into two groups receiving different kinds of ORT. The patients in group 1 (153 subjects) were treated with glucosolan and in group 2 (73 subjects), with sodium citrate in an amount of 2.5-5 lit. over the 6-hour period of treatment. The determination of the content of immunoreactive insulin, glucagon C-peptide and trypsin in the blood as the characteristics of the hormonal activity of the pancreas has made it possible to find out disturbances in the incretory and excretory activity of the pancreas in patients with acute enteric infections of different etiology. ORT with glucosolan and sodium citrate facilitates the restoration of pancreatic function in 65-70% of in patients with acute enteric infections of different etiology.
Subject(s)
Dysentery, Bacillary/therapy , Fluid Therapy , Intestinal Diseases/therapy , Pancreas/physiopathology , Salmonella Food Poisoning/therapy , Vibrio Infections/therapy , Acute Disease , Adolescent , Adult , Blood Glucose/analysis , Dysentery, Bacillary/blood , Dysentery, Bacillary/physiopathology , Female , Fluid Therapy/methods , Humans , Intestinal Diseases/blood , Intestinal Diseases/physiopathology , Male , Pancreatic Hormones/blood , Salmonella Food Poisoning/blood , Salmonella Food Poisoning/physiopathology , Vibrio Infections/blood , Vibrio Infections/physiopathologyABSTRACT
ORT effectiveness for AII cases of different etiology was studied in two groups of patients: 153 patients as ORT received glucosalan (group 1), 75 patients underwent ORT with sodium citrate in solution from 2.5 to 51 within 6 hours. Both group 1 and group 2 patients benefited from the above solutions as following 6 hours of treatment their biochemical and clinical indices improved. The patients attained normal coagulation, filter-reabsorption renal function under disappearance of dehydration and intoxication symptoms. Availability and simplicity of ORT procedure enable its usage prior to hospitalization, in outpatient departments, at home, making hospitalization unnecessary if started at the initial AII stages.