ABSTRACT
Humoral immunity was studied in 40 children presenting with idiopathic nephrotic syndrome (INS), of which 30 with minimal supposed or proven glomerular changes (MGC) and 10 with focal and segmental hyalinosis (FSH). Such patients are capable of producing in vivo active antibodies, in response to viral or bacterial infections and after anti-poliomyelitis immunisation. They present with decreased immunoglobulins G and increased immunoglobulins M during exacerbation of the disease. These abnormalities often persist during remission as well as in patients off-therapy. IgE are often increased during periods or exacerbation as well as in remission. On the contrary, the number of B lymphocytes and their distribution according to surface Ig are normal.
Subject(s)
Glomerulonephritis/immunology , Glomerulosclerosis, Focal Segmental/immunology , Nephrotic Syndrome/immunology , Adolescent , Antibody Formation , B-Lymphocytes/immunology , Child , Child, Preschool , Glomerulosclerosis, Focal Segmental/complications , Humans , Immunoglobulin A/analysis , Immunoglobulin G/analysis , Immunoglobulin M/analysis , Infant , Nephrotic Syndrome/complications , Receptors, Antigen, B-Cell/analysisABSTRACT
Cellular immunity was studied in 31 children presenting with idiopathic nephrotic syndrome (INS), of which 23 with minimal supposed or proven glomerular changes (MGC) and 8 with focal and segmental hyalinosis (FSH). In vivo, a clear hyporeactivity to the delayed hypersensitivity tests and decreased blood T lymphocytes, with a great dispersion of the values were found. Furthermore, such patients' sera display a factor inhibiting the proliferative response of the lymphocytes of patients and of control subjects, to non specific mitogens (PHA), both during exacerbation and remission periods. The hypotheses of an abnormality of cellular immunity and of the existence of an inhibitory factor in the serum of INS with MGC and FSH are discussed.
Subject(s)
Glomerulonephritis/immunology , Glomerulosclerosis, Focal Segmental/immunology , Nephrotic Syndrome/immunology , Adolescent , Child , Child, Preschool , Glomerulosclerosis, Focal Segmental/complications , Humans , Hypersensitivity, Delayed/immunology , Immunity, Cellular , Infant , Lymphocyte Activation , Nephrotic Syndrome/complications , Rosette Formation , T-LymphocytesABSTRACT
A 16 years old male presented with orthostatic hypotension with constant pulse, associated with severe constipation, decrease of sudoral secretions, weight loss and asthenia. This dysautonomia evolued during a period of 6 months and disappeared completely leaving no sequellaes. The symptoms appeared after a rubella. The authors discuss the originality of this observation among the pure pan-dysautonomia and the modes of exploration of the autonomic nervous system. Its mechanisms is probably auto-immune.
Subject(s)
Autonomic Nervous System Diseases/diagnosis , Acute Disease , Adolescent , Autonomic Nervous System Diseases/etiology , Autonomic Nervous System Diseases/immunology , Humans , MaleSubject(s)
Complement System Proteins/metabolism , Nephrotic Syndrome/immunology , Adolescent , Child , Child, Preschool , Female , Humans , Infant , MaleABSTRACT
A case of agranulocytosis, quickly and spontaneously reversible, occurring in the fourth week of infectious mononucleosis in a 7-year old girl, is reported. The interest of the case lies in the importance of the symptomatology (jaundice, eruption, fever for 40 days), the serological detection of the role of the Epstein-Barr virus and, in particular, in the presence of leukoagglutinins judged to be responsible for the agranulocytosis.
