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Bioorg Med Chem Lett
; 15(17): 3881-5, 2005 Sep 01.
Article
in English
| MEDLINE
| ID: mdl-15993068
ABSTRACT
The inhibition of cyclin-dependent kinase 4 (Cdk4) causes cell cycle arrest and restores a checkpoint that is absent in the majority of tumor cells. Compounds that inhibit Cdk4 selectively are targeted for treating cancer. Appropriate substitution of 2-aminoquinazolines is demonstrated to produce high levels of selectivity for Cdk4 versus closely related serine-threonine kinases.