ABSTRACT
CONTEXT: Studies using experimental models have demonstrated that prebiotics are involved in antiosteoporotic mechanisms. OBJECTIVE: This study was conducted to determine the impact of supplementation with prebiotics in the basal diet of ovariectomized rats with induced osteoporosis as a preclinical model. METHODS: A comprehensive systematic search was carried out in the electronic databases PubMed, Science Direct, Web of Science, Scielo, and Google through March 2022 for studies that investigated the impact of prebiotics on bone mineral density (BMD), bone mineral content (BMC), and bone biomechanics. RESULTS: The search returned 844 complete articles, abstracts, or book chapters. After detailed screening, 8 studies met the inclusion criteria. Rats (n = 206), were randomly divided between control and treatment groups. Weighted mean differences (WMDs) with the 95%CIs were used to estimate the combined effect size. Compared with the control group, dietary intake of prebiotics significantly increased bone density in the BMD subgroups, with WMDs as follows: 0.03 g/cm3, 95%CI, 0.01-0.05, P < 0.00001, n = 46; and 0.00 g/cm2, 95%CI, 0.00-0.02, P < 0.00001, n = 81; total BMD: WMD, 0.01, 95%CI, 0.01-0.02, P < 0.00001, n = 127; bone content in BMC: WMD, 0.02 g, 95%CI, 0.00-0.04, P = 0.05, n = 107; and the 3-point-bend test: WMD, 15.20 N, 95%CI, 5.92-24.47, P = 0.00001, n = 120. CONCLUSION: Prebiotics improve indicators of osteoporosis, BMD, BMC, and bone biomechanics in ovariectomized rats. More studies are needed to increase the level of evidence. SYSTEMIC REVIEW REGISTRATION: Systematic Review Protocol for Animal Intervention Studies.
ABSTRACT
A avaliação da postura corporal estática de crianças permite identificar e prevenir desordens musculoesqueléticas no estágio inicial. Objetivo: Avaliar a postura estática de alunos de uma escola pública, comparando a postura entre as faixas etárias e entre os sexos. Métodos: A amostra foi composta por 130 escolares (62 do sexo masculino e 68 do sexo feminino), os quais tinham entre 6 e 10 anos de idade. Cada escolar foi fotografado nas vistas anterior, posterior e lateral direita, e o registro fotográfico foi analisado por meio do Software de Avaliação Postural (SAPo). Resultados: Somente foi encontrada diferença entre os sexos no ângulo do tornozelo, além de interação entre sexo e faixa etária. Em relação à idade, o alinhamento horizontal dos acrômios e o alinhamento horizontal da cabeça foram diferentes entre 6-7 e 9 anos. O alinhamento horizontal da cabeça, o alinhamento horizontal das espinhas ilíacas ântero-superior (EIAS) e o alinhamento sagital do membro inferior também apresentaram interação significativa entre sexo e idade. Conclusão: Em média, a maioria dos resultados demonstra que há um alinhamento vertical e uma simetria horizontal nos ângulos analisados, com exceção do alinhamento sagital do membro inferior, do ângulo do tornozelo e do alinhamento sagital do corpo que não demostraram um alinhamento próximo do ideal. Logo, os escolares avaliados apresentam uma boa saúde musculoesquelética.
Static postural evaluation of children allows for identifying and preventing musculoskeletal disorders in the early stages. Objective:To evaluate the static posture of students at a public school, comparing age groups and sex. Methods:The sample consisted of 130 schoolchildren (62 males and 68 females) who were 6-10 years old. Each student was photographed at the anterior, posterior, and right lateral views, and the photographic records were analyzed with the Software Postural Assessment (SAPo). Results:The ankle angle was different between sexes, presenting interaction between sex and age group. Regarding age groups, the horizontal alignment of acromion processes and horizontal alignment of the head were different between 6-7 and 9 years. The horizontal alignment of the head, the horizontal alignment of the anterior superior iliac spines, and the sagittal alignment of the lower limb also showed a significant interaction between sex and age group. Conclusion:On average, most results show a vertical alignment and a horizontal symmetry in the analyzed angles. However, the sagittal alignment of the lower limb, ankle angle, and sagittal alignment of the body did not maintain satisfactory alignment. The participants of our study presented good musculoskeletal health.
ABSTRACT
Since the early 19th century, host-defense peptides (HDPs) have been known to play a crucial role in innate host defense. Subsequent work has demonstrated their role in adaptive immunity as well as their involvement in cancer and also a number of inflammatory and/or autoimmune diseases. In addition to these multiple functional activities, several studies have shown that HDP accumulation might be correlated with various human diseases and, therefore, could be used as a biomarkers for such. Thus, research has aimed to validate the clinical use of HDPs for diagnosis, prognosis, and further treatment. In this review, we outline the most recent findings related to the use of HDPs as biomarkers, their clinical and epidemiological value, and the techniques used to determine the levels of HDPs.
Subject(s)
Antimicrobial Cationic Peptides/metabolism , Immune System Diseases/diagnosis , Immune System Diseases/metabolism , Adaptive Immunity , Antimicrobial Cationic Peptides/immunology , Bacteria/immunology , Bacteria/metabolism , Biomarkers/metabolism , Early Diagnosis , Host-Pathogen Interactions , Humans , Immune System Diseases/immunology , Immune System Diseases/therapy , Immunity, Innate , Predictive Value of Tests , PrognosisABSTRACT
Abstract Tethered swimming tests are applied to evaluate propulsive forces in crawl stroke and may also be used to evaluate force applied by the movement of lower (leg kicking) and upper limbs (arm stroke). Considering the large number of recreational swimmers, this tool may be useful for coaches to evaluate the technique and force production by swimmers. As little attention has been paid to the application of these tests with recreational swimmers, the aims of this study were to verify the repeatability of the tethered swimming test for arm stroke, leg kicking and crawl stroke and to verify the relationship between performance in a 50-m test and in the tethered test with recreational swimmers. In this case, repeatability was defined as the agreement between the results of two successive evaluations. Ten male swimmers performed two 30-s maximal intensity tethered swimming tests with leg kicking, arm stroke and crawl stroke and three 50-m crawl stroke tests. Repeatability was found for mean force of all tests and for impulse evaluated in crawl stroke. Inverse relationship of the time to complete 50 m with the maximum and mean forces and with the impulse in the crawl stroke and an inverse relationship between time to complete 50 m and the mean force in the leg kicking were observed. Therefore, results from full tethered swimming tests applied with recreational swimmers may help swimming coaches.
Resumo O teste de nado estacionário é empregado para avaliar as forças propulsivas no nado crawl e também pode ser utilizado para avaliar a força aplicada pelos movimentos dos membros superiores (braçada de crawl) e inferiores (pernada de crawl). Considerando o grande número de nadadores recreacionais, esta ferramenta pode ser útil para professores avaliarem a técnica e a produção de força de seus alunos de natação. Como pouco se sabe sobre a aplicação desses testes com nadadores recreacionais, os objetivos deste estudo foram verificar a repetibilidade do teste de nado estacionário para braçada de crawl, pernada de crawl e nado crawl e verificar a associação entre o desempenho no teste de 50 m e nos testes de nado estacionário em nadadores recreacionais. Neste caso, repetibilidade foi definida como a concordância entre resultados de duas avaliações sucessivas. Dez participantes do sexo masculino realizaram dois testes máximos de nado estacionário de 30 s, executados com pernada de crawl, com braçada de crawl e com nado crawl completo e três testes máximos de 50 m crawl. Foi encontrada repetibilidade para a força média de todos os testes e para o impulso avaliado no nado crawl. Também foi observada associação negativa do tempo do teste de 50 m com as forças máxima e média e impulso no nado crawl e uma relação inversa entre o tempo dos 50 m e a força média da pernada de crawl. Portanto, resultados de teste de nado estacionário aplicados em nadadores recreacionais podem ajudar professores de natação.
Subject(s)
Humans , Adult , Swimming , Exercise Test/methods , Muscle Strength , Athletic PerformanceABSTRACT
RESUMO O peso do material escolar e o modo de transportá-lo podem contribuir para desvios posturais e dor nas costas. Por isso, o objetivo foi verificar e comparar, entre os anos escolares e os sexos, o peso do material escolar em relação ao peso corporal e o modo de transporte do material de alunos do Ensino Fundamental I, os quais deixam os seus livros em estantes na escola. Participaram 191 escolares. O peso do material escolar e o peso corporal dos alunos foram verificados com uma balança, e o modo de transporte do material foi avaliado por meio de fotos. Observou-se que 47,7% dos alunos transportavam um peso acima do limite estabelecido (10% do peso corporal do aluno), sendo que o 1º ano transportava um menor peso do que os 2º, 3º e 5º anos, mas não houve diferença entre os sexos. Foi encontrado predomínio do uso da mochila de duas alças. Contudo, apesar de a escola já ter uma estratégia para reduzir o peso do material, quase metade dos escolares transportava um peso superior a 10% do peso corporal. Logo, outras medidas para alertar os envolvidos são necessárias.
RESUMEN El peso y el modo de transporte de útiles escolares pueden contribuir con desviaciones posturales y con dolores de espalda. Por lo tanto, el objetivo fue verificar y comparar, entre los años escolares y entre los sexos, el peso de útiles escolares en relación con el peso corporal y el modo de transporte de los útiles de alumnos de una escuela primaria que dejan sus libros en estantes en la escuela. Participaron 191 alumnos. El peso de los útiles escolares y el peso corporal de los alumnos fueron verificados con balanza, y el modo de transporte fue avaluado con fotos. Entre los alumnos, 47,7% transportaban un peso mayor que el límite establecido (10% del peso corporal de los alumnos), y el 1º año transportaba menos peso que los 2º, 3º y 5º años, pero no hubo diferencia entre los sexos. Fue encontrado un predominio de mochilas con dos correas. Sin embargo, aunque la escuela ya tiene una estrategia para reducir el peso de los útiles, casi la mitad de los alumnos transportaba un peso mayor que 10% del peso corporal. Por lo tanto, son necesarias otras medidas para alertar a las personas.
ABSTRACT Schoolbag weight and mode of carrying it can contribute to postural deviations and back pain. Therefore, our objective was to determine and compare, among the school grades and between sexes, the schoolbag weight relative to body weight and the mode of carrying it of Elementary School students, who leave their books on bookcases at the school. A total of 191 students participated in the study. Schoolbag weight and students body weight were determined with a scale, and the mode of carrying the schoolbags was evaluated by means of photographs. We observed that 47.7% of the students carried a weight above the limit established (10% of the student's body weight), and the first grade students carried less weight than the 2nd, 3rd, and 5th grade students; however, no difference was observed between sexes. We observed the prevalence of using double-strap backpack. However, despite the school had a strategy to reduce the schoolbag weight, almost half of the school children carried a weight of more than 10% of body weight. Thus, other measures to raise awareness of those involved are necessary.
