Interaction models matter: an efficient, flexible computational framework for model-specific investigation of epistasis.

PURPOSE: Epistasis, the interaction between two or more genes, is integral to the study of genetics and is present throughout nature. Yet, it is seldom fully explored as most approaches primarily focus on single-locus effects, partly because analyzing all pairwise and higher-order interactions requires significant computational resources. Furthermore, existing methods for epistasis detection only consider a Cartesian (multiplicative) model for interaction terms. This is likely limiting as epistatic interactions can evolve to produce varied relationships between genetic loci, some complex and not linearly separable. METHODS: We present new algorithms for the interaction coefficients for standard regression models for epistasis that permit many varied models for the interaction terms for loci and efficient memory usage. The algorithms are given for two-way and three-way epistasis and may be generalized to higher order epistasis. Statistical tests for the interaction coefficients are also provided. We also present an efficient matrix based algorithm for permutation testing for two-way epistasis. We offer a proof and experimental evidence that methods that look for epistasis only at loci that have main effects may not be justified. Given the computational efficiency of the algorithm, we applied the method to a rat data set and mouse data set, with at least 10,000 loci and 1,000 samples each, using the standard Cartesian model and the XOR model to explore body mass index. RESULTS: This study reveals that although many of the loci found to exhibit significant statistical epistasis overlap between models in rats, the pairs are mostly distinct. Further, the XOR model found greater evidence for statistical epistasis in many more pairs of loci in both data sets with almost all significant epistasis in mice identified using XOR. In the rat data set, loci involved in epistasis under the XOR model are enriched for biologically relevant pathways. CONCLUSION: Our results in both species show that many biologically relevant epistatic relationships would have been undetected if only one interaction model was applied, providing evidence that varied interaction models should be implemented to explore epistatic interactions that occur in living systems.

Processo de cuidados entre cuidador informal e doente com necessidades paliativas no domicílio: Metassíntese / The care process between informal caregivers and patients with palliative care needs at home: Meta-synthesis / Proceso de atención entre el cuidador informal y el paciente con necesidades paliativas en el domicilio: metasíntesis

Resumo Introdução: O cuidador informal e o doente com necessidades paliativas são fundamentais no sucesso dos cuidados no domicílio, porém pouco se sabe sobre o cuidado que decorre entre os dois. Objetivos: Identificar os fatores que influenciam o cuidado entre o cuidador informal e o doente com necessidades paliativas no domicílio. Metodologia: Metassíntese seguindo a metodologia Joanna Briggs Institute. Incluíram-se estudos qualitativos com a perspetiva de cuidadores informais e/ou doentes com necessidades paliativas no domicílio. Pesquisa nas bases MEDLINE, CINHAL, Embase e Scopus (2009-2021). Resultados: Incluíram-se 30 estudos com 605 participantes. Surgiram oito temas centrais: fatores facilitadores/ dificultadores dos cuidados informais; estratégias utilizadas; a influência do tempo e da progressão da doença nos cuidados; as motivações para cuidar em casa; as aprendizagens contínuas e as funções do cuidador. Conclusão: O cuidado informal é um processo dinâmico onde se interligam fatores facilitadores/dificultadores, estratégias e a progressão da doença. Os resultados permitem compreender a experiência de cuidar e estruturar cuidados centrados na pessoa, flexíveis e adaptados ao contexto.

Abstract Introduction: Informal caregivers and patients with palliative care needs are essential for a successful home-based care experience. However, little is known about the care process between informal caregivers and these patients. Objective: To identify the factors that influence the care process between informal caregivers and patients with palliative care needs at home. Methodology: Meta-synthesis following the Joanna Briggs Institute methodology. We included qualitative studies with informal caregivers and/or patients with palliative care needs at home. We searched MEDLINE, CINHAL, Embase, and Scopus databases (2009-2021). Results: Thirty studies were included, with 605 participants. Eight main themes emerged: facilitating factors of informal care; complicating factors of informal care; strategies used; the influence of time in care; the influence of disease progression in care; motivations to provide home-based care; continuous learning; and caregiver's roles. Conclusion: Informal care is a dynamic process where facilitating/complicating factors, strategies, and disease progression are interconnected. The results contribute to understanding the care process and designing person-centered, flexible, and context-sensitive care plans.

Resumen Introducción: El cuidador informal y el paciente con necesidades paliativas son fundamentales para el éxito de los cuidados a domicilio, pero se sabe poco sobre la atención que se presta entre ambos. Objetivos: Identificar los factores que influyen en la atención entre el cuidador informal y el paciente con necesidades paliativas en el domicilio. Metodología: Metasíntesis siguiendo la metodología Joanna Briggs Institute. Se incluyeron estudios cualitativos con la perspectiva de cuidadores informales y/o pacientes con necesidades paliativas en el domicilio. Búsqueda en las bases MEDLINE, CINHAL, Embase y Scopus (2009-2021). Resultados: Se incluyeron 30 estudios con 605 participantes. Surgieron ocho temas centrales: factores que facilitan / dificultan los cuidados informales; estrategias utilizadas; influencia del tiempo y de la progresión de la enfermedad en los cuidados; motivaciones para cuidar en casa; aprendizaje continuo y funciones del cuidador. Conclusión: Los cuidados informales son un proceso dinámico en el que se incluyen factores que facilitan / dificultan, estrategias y progresión de la enfermedad. Los resultados permiten comprender la experiencia de cuidar y estructurar unos cuidados centrados en la persona, flexibles y adaptados al contexto.

Chondroprotective effect of melatonin and strontium ranelate in animal model of osteoarthritis.

PURPOSE: To analyze the action of strontium ranelate (SR) and melatonin in isolation or in association in knees, liver and kidneys of rats Wistar with induced osteoarthritis (OA). METHODS: Thirty male rats were induced to OA through an anterior cruciate ligament transection (ACLT), and treated with melatonin and SR in isolation or in association. Morphological, histopathological, histochemical and morphometric analysis were realized of the structure of the articular capsule, as well as histopathological analysis of liver and kidneys from the animals. RESULTS: The experimental model was successful. The association of the drugs presented chondroprotective pharmacodynamics. However, more successful results were identified from analysis of animals in which received melatonin in isolation, regarding biochemical parameters of glutamic oxalacetic transaminase. The prepared slide samples of liver and kidneys from groups submitted to the isolated use of SR and melatonin or the association of these drugs presented no differences, when compared to the control group. DISCUSSION: The administration of the drugs presented chondroprotective effect and prevented from the aggravation of articulate damages, and was not capable of modifying the histology of liver or kidneys. This finding suggests a safe association for the treatment of OA, however it requires further investigation in order to expand therapeutic perspectives regarding improvements of the quality of life of individuals in our society.

Alternative polyadenylation factors link cell cycle to migration.

BACKGROUND: In response to a wound, fibroblasts are activated to migrate toward the wound, to proliferate and to contribute to the wound healing process. We hypothesize that changes in pre-mRNA processing occurring as fibroblasts enter the proliferative cell cycle are also important for promoting their migration. RESULTS: RNA sequencing of fibroblasts induced into quiescence by contact inhibition reveals downregulation of genes involved in mRNA processing, including splicing and cleavage and polyadenylation factors. These genes also show differential exon use, especially increased intron retention in quiescent fibroblasts compared to proliferating fibroblasts. Mapping the 3' ends of transcripts reveals that longer transcripts from distal polyadenylation sites are more prevalent in quiescent fibroblasts and are associated with increased expression and transcript stabilization based on genome-wide transcript decay analysis. Analysis of dermal excisional wounds in mice reveals that proliferating cells adjacent to wounds express higher levels of cleavage and polyadenylation factors than quiescent fibroblasts in unwounded skin. Quiescent fibroblasts contain reduced levels of the cleavage and polyadenylation factor CstF-64. CstF-64 knockdown recapitulates changes in isoform selection and gene expression associated with quiescence, and results in slower migration. CONCLUSIONS: Our findings support cleavage and polyadenylation factors as a link between cellular proliferation state and migration.

Differences between the activity of the masticatory muscles of adults with cerebral palsy and healthy individuals while at rest and in function.

OBJECTIVE: The aim of the present study was to compare the electromyographic activity of masticatory muscles of adult patients with different degrees of oral motor impairment (cerebral palsy) with the electromyographic activity of healthy individuals in a control group. Electromyographic activity was compared when the masticatory muscles were at rest and in motion. DESIGN: Thirty adult patients with cerebral palsy and 30 subjects without neuromotor disorders were enrolled in the present study. Oral motor function impairment was classified for each subject according to the Orofacial Motor Function Assessment Scale. Surface electromyography was bilaterally recorded in the masseter and anterior temporalis muscles at rest, during maximal voluntary clench and mouth opening. Comparisons between the groups were statistically assessed using Mann-Whitney test. RESULTS: At rest and mouth opening, electromyographic values were higher among patients with cerebral palsy than control group. During maximal voluntary clench, the opposite occurred. The degree of oral motor impairment affected mouth opening. CONCLUSION: There are significant differences in masticatory muscle activity between adult patients with CP and healthy individuals, and the degree of oral motor impairment is important. SIGNIFICANCE: To improve the masticatory function of these patients, muscle therapy should approach rest, mouth opening and clenching differently.

FastLSU: a more practical approach for the Benjamini-Hochberg FDR controlling procedure for huge-scale testing problems.

MOTIVATION: We address a common problem in large-scale data analysis, and especially the field of genetics, the huge-scale testing problem, where millions to billions of hypotheses are tested together creating a computational challenge to control the inflation of the false discovery rate. As a solution we propose an alternative algorithm for the famous Linear Step Up procedure of Benjamini and Hochberg. RESULTS: Our algorithm requires linear time and does not require any P-value ordering. It permits separating huge-scale testing problems arbitrarily into computationally feasible sets or chunks Results from the chunks are combined by our algorithm to produce the same results as the controlling procedure on the entire set of tests, thus controlling the global false discovery rate even when P-values are arbitrarily divided. The practical memory usage may also be determined arbitrarily by the size of available memory. AVAILABILITY AND IMPLEMENTATION: R code is provided in the supplementary material. CONTACT: sbatista@cs.princeton.edu SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Fasting in elective surgical patients: comparison among the time prescribed, performed and recommended on perioperative care protocols / Jejum em pacientes cirúrgicos eletivos: comparação entre o tempo prescrito, praticado e o indicado em protocolos de cuidados perioperatórios

Background: Prolonged preoperative fasting may impair nutritional status of the patient and their recovery. In contrast, some studies show that fasting abbreviation can improve the response to trauma and decrease the length of hospital stay. Aim: Investigate whether the prescribed perioperative fasting time and practiced by patients is in compliance with current multimodal protocols and identify the main factors associated. Methods: Cross-sectional study with 65 patients undergoing elective surgery of the digestive tract or abdominal wall. We investigated the fasting time in the perioperative period, hunger and thirst reports, physical status, diabetes diagnosis, type of surgery and anesthesia. Results: The patients were between 19 and 87 years, mostly female (73.8%). The most performed procedure was cholecystectomy (47.69%) and general anesthesia the most used (89.23%). The most common approach was to start fasting from midnight for liquids and solids, and most of the patients received grade II (64.6%) to the physical state. The real fasting average time was 16 h (9.5-41.58) was higher than prescribed (11 h, 6.58 -26.75). The patients submitted to surgery in the afternoon were in more fasting time than those who did in the morning (p<0.001). The intensity of hunger and thirst increased in postoperative fasting period (p=0.010 and 0.027). The average period of postoperative fasting was 18.25 h (3.33-91.83) and only 23.07% restarted feeding on the same day. Conclusion: Patients were fasted for prolonged time, higher even than the prescribed time and intensity of the signs of discomfort such as hunger and thirst increased over time. To better recovery and the patient's well-being, it is necessary to establish a preoperative fasting abbreviation protocol.

Racional: O jejum perioperatório prolongado pode prejudicar estado nutricional do paciente e sua recuperação. Em contrapartida, estudos mostram que abreviação do jejum pode melhorar a resposta ao trauma e diminuir o tempo de internação. Objetivo: Investigar se o tempo de jejum perioperatório prescrito e praticado pelos pacientes se encontra em conformidade com os protocolos multimodais atuais e identificar os principais fatores associados. Métodos: Estudo transversal com 65 pacientes, submetidos às operações eletivas do aparelho digestivo ou parede abdominal. Foi investigado o tempo de jejum no período perioperatório, relatos de fome e sede, classificação do estado físico, diagnóstico de diabete, tipo de operação e de anestesia. Resultados: Os pacientes tinham entre 19 e 87 anos, sendo a maioria do sexo feminino (73,8%). O procedimento mais realizado foi colecistectomia (47,69%) e a anestesia geral a mais usada (89,23%). A orientação mais frequente foi jejum a partir de meia noite para líquidos e sólidos e a maior parte dos pacientes recebeu classificação II (64,6%) para o estado físico. O tempo médio de jejum real foi 16 h (9,5-41,58) sendo maior que o prescrito (11 h; 6,58-26,75) com p<0,001. Aqueles que realizaram a operação no período da tarde ficaram mais tempo de jejum do que aqueles do período matutino (p<0,001). A intensidade de fome e sede aumentou no período de jejum pós-operatório (p=0,010 e 0,027). O período de jejum médio pós-operatório foi 18,25 h (3,33-91,83) e apenas 23,07% reiniciou a alimentação no mesmo dia. Conclusão: Os pacientes permaneceram em jejum por tempo prolongando, ainda maior que o tempo prescrito e a intensidade dos sinais de desconforto como fome e sede aumentaram ao longo do tempo. Para melhor recuperação e bem-estar do paciente, faz-se necessário instituir um protocolo de abreviação do jejum perioperatório.

FASTING IN ELECTIVE SURGICAL PATIENTS: COMPARISON AMONG THE TIME PRESCRIBED, PERFORMED AND RECOMMENDED ON PERIOPERATIVE CARE PROTOCOLS.

BACKGROUND: Prolonged preoperative fasting may impair nutritional status of the patient and their recovery. In contrast, some studies show that fasting abbreviation can improve the response to trauma and decrease the length of hospital stay. AIM: Investigate whether the prescribed perioperative fasting time and practiced by patients is in compliance with current multimodal protocols and identify the main factors associated. METHODS: Cross-sectional study with 65 patients undergoing elective surgery of the digestive tract or abdominal wall. We investigated the fasting time in the perioperative period, hunger and thirst reports, physical status, diabetes diagnosis, type of surgery and anesthesia. RESULTS: The patients were between 19 and 87 years, mostly female (73.8%). The most performed procedure was cholecystectomy (47.69%) and general anesthesia the most used (89.23%). The most common approach was to start fasting from midnight for liquids and solids, and most of the patients received grade II (64.6%) to the physical state. The real fasting average time was 16 h (9.5-41.58) was higher than prescribed (11 h, 6.58 -26.75). The patients submitted to surgery in the afternoon were in more fasting time than those who did in the morning (p<0.001). The intensity of hunger and thirst increased in postoperative fasting period (p=0.010 and 0.027). The average period of postoperative fasting was 18.25 h (3.33-91.83) and only 23.07% restarted feeding on the same day. CONCLUSION: Patients were fasted for prolonged time, higher even than the prescribed time and intensity of the signs of discomfort such as hunger and thirst increased over time. To better recovery and the patient's well-being, it is necessary to establish a preoperative fasting abbreviation protocol.

Test-retest reliability of electromyographic variables of masseter and temporal muscles in patients with cerebral palsy.

INTRODUCTION: The aim of this study was to evaluate the reliability of surface electromyography of the masticatory muscles in patients with cerebral palsy. METHODS: Surface electromyography was performed over the masseter and temporal muscles in 15 patients with cerebral palsy with the mandible at rest and during maximum clenching effort in two sessions. The data were analyzed using the root mean square amplitude, mean frequency, median frequency, zero crossings and approximate entropy. RESULTS: In the within-day evaluations, intraclass correlation coefficients were higher (0.80-0.98) for the all electromyography variables and muscles during maximum clenching effort. In the resting position, the coefficients revealed good to excellent reliability (0.61-0.95) for root mean square, mean frequency, median frequency and zero crossings and fair to good reliability (0.53-0.74) for approximate entropy. In the between-day evaluations, the coefficients revealed good to excellent reliability (0.60-0.86) for mean frequency, median frequency, zero crossings and approximate entropy. In the resting position, the coefficients revealed poor to fair reliability (0.23-0.57) for all electromyography variables studied. The root mean square had the highest standard errors during maximum clenching effort (2.37-5.91) and at rest (1.47-6.86). CONCLUSION: Mean frequency, median frequency and approximate entropy are the most reliable variables of surface electromyography signals of the masseter and temporal muscles during maximum clenching effort in individuals with cerebral palsy. These measures can be used to evaluate the function and behaviour of the masticatory muscles in this population following oral rehabilitation and surgical oral procedures as well as for the study the physiology of these muscles.

Heritability and genomics of gene expression in peripheral blood.

We assessed gene expression profiles in 2,752 twins, using a classic twin design to quantify expression heritability and quantitative trait loci (eQTLs) in peripheral blood. The most highly heritable genes (∼777) were grouped into distinct expression clusters, enriched in gene-poor regions, associated with specific gene function or ontology classes, and strongly associated with disease designation. The design enabled a comparison of twin-based heritability to estimates based on dizygotic identity-by-descent sharing and distant genetic relatedness. Consideration of sampling variation suggests that previous heritability estimates have been upwardly biased. Genotyping of 2,494 twins enabled powerful identification of eQTLs, which we further examined in a replication set of 1,895 unrelated subjects. A large number of non-redundant local eQTLs (6,756) met replication criteria, whereas a relatively small number of distant eQTLs (165) met quality control and replication standards. Our results provide a new resource toward understanding the genetic control of transcription.

Effect of a hyperbolide mastication apparatus for the treatment of severe sleep bruxism in a child with cerebral palsy: long-term follow-up.

PURPOSE: Sleep bruxism is common among the various oromotor alterations found in individuals with cerebral palsy (CP). Few studies have investigated the use of the mastication device denominated "hyperbola" (HB) and none was found describing the use of such a device for the treatment of bruxism in children with CP. The aim of the present study was to evaluate the effect of the HB on electromyographic (EMG) activity in the jaw-closing muscles and the reduction in sleep bruxism in a child with CP using surface EMG analysis before and after nine months of treatment. METHODS: A seven-year-old boy with severe spastic CP and sleep bruxism was enrolled in this study. The HB was chosen as the treatment option for sleep bruxism in this case because the child did not accept an occlusal splint. The HB has a hyperbolic shape and is made of soft, non-toxic, odorless, tasteless silicone. There are five different sizes of HB manufactured based on the diversity of tooth sizes. This device produces proprioceptive excitation in the dentoalveolar nerve, spindles and Golgi tendon organs. HB has been employed for the treatment of temporomandibular disorder, abnormal oro-dental development, abnormal occlusion, xerostomy, halitosis and bruxism. HB therapy was performed for 5 min six times a day over a nine-week period. Surface EMG of the mandible at rest and during maximum contraction was performed on the masseter and temporalis muscles bilaterally to evaluate electromyographic activity before and after nine months of HB usage. RESULTS: HB usage led to a visible tendency toward the reorganization of mastication dynamics, achieving a marked balance in electromyographic activity of the jaw-closing muscles and improving the child's quality of life. CONCLUSION: Based on the findings of the present study, this noninvasive therapy may be useful for individuals with cerebral palsy due to its positive effects and low cost, which allows its use in the public health realm. Further clinical studies with a larger sample size are needed to validate these results and allow the development of a new treatment protocol for patients with spastic cerebral palsy.

Sex differences in the human peripheral blood transcriptome.

BACKGROUND: Genomes of men and women differ in only a limited number of genes located on the sex chromosomes, whereas the transcriptome is far more sex-specific. Identification of sex-biased gene expression will contribute to understanding the molecular basis of sex-differences in complex traits and common diseases. RESULTS: Sex differences in the human peripheral blood transcriptome were characterized using microarrays in 5,241 subjects, accounting for menopause status and hormonal contraceptive use. Sex-specific expression was observed for 582 autosomal genes, of which 57.7% was upregulated in women (female-biased genes). Female-biased genes were enriched for several immune system GO categories, genes linked to rheumatoid arthritis (16%) and genes regulated by estrogen (18%). Male-biased genes were enriched for genes linked to renal cancer (9%). Sex-differences in gene expression were smaller in postmenopausal women, larger in women using hormonal contraceptives and not caused by sex-specific eQTLs, confirming the role of estrogen in regulating sex-biased genes. CONCLUSIONS: This study indicates that sex-bias in gene expression is extensive and may underlie sex-differences in the prevalence of common diseases.

Comparative analysis of the exoproteomes of Listeria monocytogenes strains grown at low temperatures.

This article presents the major differences in the exoproteomes of Listeria monocytogenes strains grown at 11°C and 20°C, and their comparison to 37°C, the optimal temperature of growth of this foodborne pathogenic bacteria. A set of four strains previously characterized and representing the genetic diversity of the species was used. Two were virulent, of which one was persistent, and two were low virulent strains. The proteins secreted by the strains grown in minimal medium were separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and identified by liquid chromatography tandem mass spectrometry. The heterogeneity among the four strains concerning the 15 major proteins detected was noticed. No clear association of exoproteome with virulence or genotype was found. Cluster analysis of the protein patterns of the strains suggests an increasing differentiation of strain response with low temperatures, highlighting the importance of the study of the exoproteomes. The main finding was the lack of some proteins in the exoproteome of the persistent strain, namely, flagellin (FlaA) and of OppA/oligopeptide ABC transporter, when compared to the other strains. In fact, these two proteins differ in abundance between strains grown at low temperature. Moreover, FlaA was the only glycoprotein identified in the exoproteomes. An attempt is made here to assess the relevance of the major exoproteins differentially detected. The investigation of the exoproteomes of other persistent and sporadic strains will allow identification of proteins involved in adaptation of particular L. monocytogenes strains to low temperatures in use throughout the food chain.

Effects of neuromuscular electrical stimulation, laser therapy and LED therapy on the masticatory system and the impact on sleep variables in cerebral palsy patients: a randomized, five arms clinical trial.

BACKGROUND: Few studies demonstrate effectiveness of therapies for oral rehabilitation of patients with cerebral palsy (CP), given the difficulties in chewing, swallowing and speech, besides the intellectual, sensory and social limitations. Due to upper airway obstruction, they are also vulnerable to sleep disorders. This study aims to assess the sleep variables, through polysomnography, and masticatory dynamics, using electromiography, before and after neuromuscular electrical stimulation, associated or not with low power laser (Gallium Arsenide- Aluminun, =780 nm) and LED (= 660 nm) irradiation in CP patients. METHODS/DESIGN: 50 patients with CP, both gender, aged between 19 and 60 years will be enrolled in this study. The inclusion criteria are: voluntary participation, patient with hemiparesis, quadriparesis or diparetic CP, with ability to understand and respond to verbal commands. The exclusion criteria are: patients undergoing/underwent orthodontic, functional maxillary orthopedic or botulinum toxin treatment. Polysomnographic and surface electromyographic exams on masseter, temporalis and suprahyoid will be carry out in all sample. Questionnaire assessing oral characteristics will be applied. The sample will be divided into 5 treatment groups: Group 1: neuromuscular electrical stimulation; Group 2: laser therapy; Group 3: LED therapy; Group 4: neuromuscular electrical stimulation and laser therapy and Group 5: neuromuscular electrical stimulation and LED therapy. All patients will be treated during 8 consecutive weeks. After treatment, polysomnographic and electromiographic exams will be collected again. DISCUSSION: This paper describes a five arm clinical trial assessing the examination of sleep quality and masticatory function in patients with CP under non-invasive therapies. TRIAL REGISTRATION: The protocol for this study is registered with the Brazilian Registry of Clinical Trials - ReBEC RBR-994XFS.

Análise comparativa entre os mecanismos de trauma, as lesões e o perfil de gravidade das vítimas, em Catanduva - SP / Mechanisms of trauma, main injuries and severity of patients’ conditions in Catanduva - SP

OBJETIVO: Realizar uma análise comparativa entre os principais mecanismos de trauma, a gravidade das vítimas e os principais ferimentos que proporcionaram. MÉTODO: Estudo randomizado de 1486 fichas de vítimas traumatizadas atendidas pela Unidade de Resgate do Corpo de Bombeiros em Catanduva - SP, no período de janeiro/1997 a dezembro/2003. Foi realizada uma avaliação a partir dos itens ferimentos, Revised Trauma Score e mecanismos de trauma, cujas variáveis foram expressas em porcentagens e correlacionadas pelo Teste X². RESULTADOS: Houve predomínio de acidentes motociclísticos com 42,2 por cento dos traumas. As regiões corpóreas mais acometidas foram os membros inferiores/cintura pélvica (32,2 por cento). Os ferimentos superficiais acometeram 88 por cento das vítimas. Para todos os eventos, prevaleceram vítimas com RTS=6 excetuando-se os acidentes envolvendo veículos pesados em que 25 por cento das vítimas obtiveram RTS<2. As quedas representaram 63,4 por cento dos eventos quando excluimos da análise os acidentes de trânsito. Houve correlação estatística somente entre o mecanismo de trauma e a região corpórea lesada (p<0,01). Os membros inferiores/pelve foram mais acometidos em atropelamentos e acidentes de moto. Cabeça/pescoço foram lesados nas agressões, nas quedas e nos acidentes envolvendo veículos pesados e automóveis. Os ciclistas apresentaram similaridade de lesões em cabeça/pescoço e membros inferiores/pelve. CONCLUSÕES: Em Catanduva prevaleceram motociclistas traumatizados, e acometidos, principalmente, os membros inferiores e a pelve. A maioria das vítimas sofreu ferimentos superficiais, decorrentes de traumas leves.