ABSTRACT
PURPOSE: To describe the effectiveness and safety of nicergoline in patients with epithelial corneal defect or corneal ulcer due to neurotrophic keratitis (NK). METHODS: A prospective case series review was performed in 14 patients with NK who started treatment with nicergoline as an off-label prescription from January to November 2020. Patients with a epithelial defect or corneal ulcer due to NK were treated with oral nicergoline. RESULTS/SERIAL CASES: Complete corneal healing was observed in 10 (71.4%) of the 14 patients after 25.6 ± 26.60 days (range 7-90) with nicergoline. In three (21.5%) patients wound healing was not achieved, and one patient (7.1%) was lost to follow-up. The mean time between diagnosis and the starting of nicergoline was 10.92 ± 8.85 days (0-28). No adverse effects of nicergoline were observed. CONCLUSION: Nicergoline as an adjunctive treatment for NK showed a potential use in the healing of epithelial defect in real-life clinical practice.
Subject(s)
Corneal Ulcer , Nicergoline , Humans , Corneal Ulcer/diagnosis , Corneal Ulcer/drug therapyABSTRACT
El submarinismo puede practicarse de manera recreativa o profesional. En ambas modalidades el buceador puede verse expuesto a riesgos como el síndrome de descompresión y al consecuente uso de la cámara hiperbárica, la hiperoxigenación de la botella de gases, el barotrauma y la inmersión en circuitos cerrados. Estas situaciones tienen en común la exposición a una gran diferencia de presiones, lo que puede provocar una amplia gama de alteraciones, incluidas las oftalmológicas. El desarrollo de una miopía de índice y catarata de tipo nuclear son hallazgos oculares frecuentemente asociados al aumento de presión de oxígeno. En este contexto, se establece un desequilibrio entre especies oxidativas y defensas antioxidantes como el glutatión, que posee un papel clave en el mantenimiento de la transparencia del cristalino. Presentamos los casos de 2 pacientes jóvenes, pescadores de coral, que presentaron una miopización reciente y progresiva asociada a cataratas nucleares
Scuba diving can be practiced recreationally or professionally. In both modalities the diver can be exposed to risks such as decompression syndrome and thus, the use of a hyperbaric chamber, hyper-oxygenation of the gas cylinder, barotrauma, and immersion in closed circuits. These situations have some phenomena in common, such as the great pressure differences, which can cause a wide range of alterations, including ophthalmological ones. The development of index myopia and nuclear cataract are ocular findings frequently associated with increased oxygen pressure. In this context, an imbalance is established between oxidative species and antioxidant defences, such as glutathione, which has a key role in maintaining the transparency of the lens. The cases are presented of 2 young coral fisher patients, who had recently developed a progressive myopisation associated with nuclear cataracts
Subject(s)
Humans , Male , Middle Aged , Myopia/etiology , Cataract/etiology , Diving/adverse effects , Decompression Sickness/etiology , Risk Factors , Occupational Diseases/etiology , Visual AcuityABSTRACT
Scuba diving can be practiced recreationally or professionally. In both modalities the diver can be exposed to risks such as decompression syndrome and thus, the use of a hyperbaric chamber, hyper-oxygenation of the gas cylinder, barotrauma, and immersion in closed circuits. These situations have some phenomena in common, such as the great pressure differences, which can cause a wide range of alterations, including ophthalmological ones. The development of index myopia and nuclear cataract are ocular findings frequently associated with increased oxygen pressure. In this context, an imbalance is established between oxidative species and antioxidant defences, such as glutathione, which has a key role in maintaining the transparency of the lens. The cases are presented of 2 young coral fisher patients, who had recently developed a progressive myopisation associated with nuclear cataracts.
Subject(s)
Descemet Stripping Endothelial Keratoplasty/adverse effects , Endothelium, Corneal/transplantation , Fuchs' Endothelial Dystrophy/surgery , Graft Rejection/diagnostic imaging , Aged, 80 and over , Air , Allografts , Descemet Membrane/pathology , Descemet Membrane/surgery , Female , Graft Rejection/diagnosis , Humans , Postoperative Complications/diagnosis , Postoperative Complications/etiology , Tissue Adhesions/diagnosis , Tissue Adhesions/etiologyABSTRACT
Las lentes de contacto blandas son una buena alternativa al uso de gafas para la corrección de defectos refractivos. Sin embargo, un mal uso puede asociarse a complicaciones. La manipulación incorrecta, la mala higiene o el sobreuso de dichas lentes pueden producir mala tolerancia, inflamación ocular e incluso secuelas visuales. En esta revisión se describen las complicaciones más frecuentes, y también las más graves, de tipo infeccioso y no infeccioso asociadas al uso de lentes de contacto blandas, así como las recomendaciones para su correcto uso
Soft contact lenses are a good alternative to the use of glasses for the correction of refractive defects. However, improper use can be associated with complications. Incorrect handling, poor hygiene, or over-use of the lenses can lead to poor tolerance, eye inflammation, and even visions sequelae. In this review, the most common and also the most serious are described, including the infectious and non-infectious complications associated with the use of soft contact lenses, including recommendations for their correct use
Subject(s)
Humans , Male , Female , Contact Lenses, Hydrophilic/adverse effects , Eye Diseases/etiology , Eye Diseases/classification , Cornea/physiopathology , Corneal Ulcer/etiology , Keratoconjunctivitis/etiology , Conjunctivitis, Allergic/etiology , Keratitis/etiologyABSTRACT
Soft contact lenses are a good alternative to the use of glasses for the correction of refractive defects. However, improper use can be associated with complications. Incorrect handling, poor hygiene, or over-use of the lenses can lead to poor tolerance, eye inflammation, and even visions sequelae. In this review, the most common and also the most serious are described, including the infectious and non-infectious complications associated with the use of soft contact lenses, including recommendations for their correct use.
