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Int J Biol Macromol ; 193(Pt B): 1572-1586, 2021 Dec 15.
Article in English | MEDLINE | ID: mdl-34743030

ABSTRACT

The ecofriendly cellulose and gelatin provided sustainable and abundant sugars: d-ribofuranose, and 2-Deoxy-ribofuranose (starting reactants for preparative synthetic green chemistry pathways of charge transfer complexes. The natural available sugars d-ribofuranose, and 2-Deoxy-ribofuranose were obtained from facile hydrolysis of cellulose and gelatin natural macromolecules. Successive, low cost and facile alkaline- and acid hydrolysis of Deoxyribonucleic acid (DNA, from gelatin animal source) and ribonucleic acid (RNA, from cellulose plant source) yield the simple sugars: d-ribofuranose and 2-Deoxy-ribofuranose. Eight optically and biologically active charge transfer complexes were prepared from the reaction of the above sugars efficiently intercalated with two new prepared thiophene Schiff Lewis (electron donors) bases: 2-((2Hydroxybenzylidene) amino)-4, 5, 6, 7-tetrahydrobenzo [b] thiophene-3-carbonitrile (D1, 2-((Furan-2ylmethylene) amino) 4,5,6,7 tetrahydrobenzo [b] thiophene-3-carbonitrile (D2). The chemical structures of these prepared Schiff bases were confirmed using the mass spectra. The successful intercalation of the sugar units with the Lewis bases was ascertained using powder x ray diffraction. The molecular structures of the reaction products were proposed based on FTIR, 1H NMR. The optical activity of charge transfer complexes were confirmed using UV-Vis. Absorption spectroscopy. The surface morphology, microstructures, and particle size of the donors and charge transfer complexes were determined using scanning electron microscopy (SEM). The Lewis bases (D1) and (D2) showed no antimicrobial activity, while their charge transfer complexes showed good antimicrobial activity, suggesting their pharmaceutical and medicinal applications due to the potent biological activity against wide spread microbial microorganisms of Gram positive and Gram positive bacteria as well as some fungal species.


Subject(s)
Biological Products/chemistry , Coordination Complexes/chemistry , DNA/chemistry , Macromolecular Substances/chemistry , Schiff Bases/chemistry , Thiophenes/chemistry , Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/pharmacology , Bacteria/drug effects , Biological Products/pharmacology , Fungi/drug effects , Furans/chemistry , Furans/pharmacology , Macromolecular Substances/pharmacology , Magnetic Resonance Spectroscopy/methods , Microbial Sensitivity Tests/methods , Molecular Structure , RNA/chemistry , Spectroscopy, Fourier Transform Infrared/methods , Sugars/chemistry
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