[THE ROLE OF VITAMIN D IN THE DEVELOPMENT OF PSORIASIS AND ACNE].

The article discusses the role of vitamin D in the development of skin pathology - in particular, psoriasis and acne. In some publications the results of vitamin D sufficiency in patients with these diseases are cited, but there is still insufficient information to draw definitive conclusions about the role of vitamin D in their development. The aim of the study was to assess the role of vitamin D in psoriasis and acne development. The case-control study involved 66 people, including 20 patients with psoriasis (group 1), 20 with acne (group 2) and 26 healthy individuals (control group). All participants in the study were determined the level of plasma vitamin 25 (OH)D; in patients with psoriasis PASI index to determine the severity of the disease was calculated. Vitamin 25(OH)D deficiency was detected in a significant majority of patients with skin diseases, and its average plasma level in each group was significantly lower than in the control group. There was a correlation between vitamin 25(OH)D deficiency and psoriasis severity. In patients with psoriasis and acne, vitamin D preparations should be included in the treatment complex to increase the effectiveness of therapy.

FEATURES OF MICROBIOTA IN PSORIATIC DISEASE: FROM SKIN AND GUT PERSPECTIVES (REVIEW).

Psoriatic disease is a chronic inflammatory disease characterized by skin lesions. Psoriasis development has been associated both with genetic and environmental factors. Though skin and gut microbiota has been implicated in number of pathologies including atopic dermatitis, inflammatory bowel disease, Crohn's disease, allergy, and obesity, its role has been poorly studied in psoriatic disease, which incorporates both psoriasis and psoriatic arthritis. This literature review summarizes the most recent and major findings on microbiota features in psoriatic disease. Despite conflicting findings, psoriasis patients were frequently found to have distinct microbial composition in both skin and guts especially in the major bacterial phyla, Firmicutes, Bacteroidetes, and genus Akkermansia. Furthermore, bacterial DNA has been found in psoriatic patients both locally and systemically, and altogether suggesting a crucial role of bacteria in psoriatic disease and future studies in this field.

СLINICAL AND LABORATORY CHARACTERISTICS OF PATIENTS WITH ADOLESCENCE ACNE AND ACNE TARDA.

Acne is a chronic recurrent androgen-mediated disease of the pilosebaceous complex with a multifactorial genetically determined development mechanism. Currently, there is a tendency to persistent course of the disease, resistance to therapy forms of acne, late debut and change the clinical picture of acne. This could be due to various factors, such as polycystic ovary syndrome, microadenoma and pituitary adenoma, congenital adrenal hyperplasia, SAHA syndrome, etc. Objective - to study the degree of incidence of hyperprolactinemia in patients with acne and features of the clinical course of juvenile and late acne with a background of hyperprolactinemia. We conducted a case-control study, which included 267 patients with varying disease severity. All patients underwent clinical and dermatological examination and determination of prolactin level. The study found that hyperprolactinemia, associated and nonassociated with adenoma, or pituitary microadenoma, can act as a primary factor in the development of acne, promote the persistence of the disease, as well as change skin manifestations in the form of an increase in the area of skin lesions with a smaller accumulation of sebaceous follicles and low androgen-sensitivity, such as the lower third of the back. Thus, in the diagnosis of acne vulgaris, it is necessary to evaluate the hormonal profile of patients, in particular prolactin, especially in the presence of a persistent course, a late start, resistant to therapy forms.