[New alloantisera to antigenic determinant I--J, their specificity and effect on the course of tuberculous infection in mice]. / Novye alloantisyvorotki k antigennoi determinante I--J, ikh spetsifichnosti i vliianie na techenie tuberkuleznoi infektsii u myshei.

Preparations of anti-I--J alloantisera with higher activity were obtained by a new method, based on induction of expression of the I--J determinant in donor suppressor cells, immunization of mice with such cells, and subsequent elimination of contaminating anti-idiotypic antibodies from antisera by their adsorption on the cells of the recipient murine strain sharing induced idiotype with the donor cells. After adsorption anti-I--J activity remained unchanged. The antisera thus obtained were found active in the standard cytotoxic assay (working dilution greater than or equal to 1:20). The injection of anti-I--Jk antiserum to CBA mice prolonged the survival time of the animals and increased the parameters of the cell-mediated immunity after infection with Mycobacterium tuberculosis virulent strain H37Rv.