ABSTRACT
Abstract@#Chloroformic fraction from the aerial parts of Bassia dasyphylla (fisch. et mey.) ktze. growing in Mongolia have been studied by means of Gas Chromatography Mass spectrometry method. Benzyl alcohol, phenol 2-methoxy, 2-methoxy-4-vinylphenol, 2-propenoicacid, 3- (2-hydroxyphenol)-,(E), Ibuprofen methyl ester, 3’,5’-dimethoxyacetophenone, 3-hydroxy-β-damascone, megastigmatrienone, 5-hydroxy-7-methoxy-2-(p-methoxyphenyl) -6,8-dimethyl-4-chromanon 18 compounds were determined and found for the first time from this plant species.
ABSTRACT
Two new xanthone glycosides, corymbiferin 3-O-beta-D-glucopyranoside (1) and swertiabisxanthone-I 8'-O-beta- d-glucopyranoside (2), were isolated from Gentianella amarella ssp. acuta, along with eight known xanthones: triptexanthoside C, veratriloside, corymbiferin 1-O-glucoside, swertianolin, norswertianolin, swertiabisxanthone-I, bellidin, and bellidifolin, four of them identified for the first time in G. amarella ssp. acuta. The isolation was conducted mainly by centrifugal partition chromatography, and the structures of the isolated compounds were established on the basis of spectrometric data including 2D NMR and mass spectrometry. Xanthones were weakly active against acetylcholinesterase (AChE), except triptexanthoside C, which inhibited AChE with an IC(50) of 13.8 +/- 1.6 microM. Some compounds were active against monoamine oxidases (MAO): bellidin and bellidifolin showed interesting inhibitory activity of MAO A, while swertianolin, the 8-O-glucopyranoside form of bellidifolin, gave 93.6% inhibition of MAO B activity at 10(-5) M.
Subject(s)
Cholinesterase Inhibitors/isolation & purification , Cholinesterase Inhibitors/pharmacology , Gentianella/chemistry , Glycosides/isolation & purification , Glycosides/pharmacology , Monoamine Oxidase Inhibitors/isolation & purification , Monoamine Oxidase Inhibitors/pharmacology , Plants, Medicinal/chemistry , Xanthones/isolation & purification , Xanthones/pharmacology , Cholinesterase Inhibitors/chemistry , Glucosides , Glycosides/chemistry , Molecular Structure , Mongolia , Monoamine Oxidase Inhibitors/chemistry , Nuclear Magnetic Resonance, Biomolecular , Xanthones/chemistryABSTRACT
A new diterpenoid alkaloid was isolated from the overground parts of ACONITUM BARBATUM Pers. (Ranuncluaceae). Its structure was elucidated by spectroscopic methods as 11-acetyl-1,19-epoxydenudatine.
