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1.
Genetika ; 26(5): 925-35, 1990 May.
Article in Russian | MEDLINE | ID: mdl-2397886

ABSTRACT

Gene geography is considered in this work as the instrument for analysis of population's gene pool. To be effective in this analysis, gene geography should move from mapping of gene frequencies for each gene (and phenes) to construction of genogeographical atlas, as a collection of maps generated by computer, following some strongly defined principles and methods, and joined together, according to general task and the programme of investigation. Brief version of regional genogeographical atlas of Mongolians and the other peoples of Central Asia is presented in the article. This atlas includes computer-generated maps of AB0, Hp, Gc, G'3, Tf, GLO, EstD and PGM1 gene frequencies as well as computer-generalized maps of Mongolian gene pool.


Subject(s)
Computer Simulation , Gene Frequency , Genetics, Medical , Atlases as Topic , Geography , Humans
2.
Genetika ; 26(2): 332-40, 1990 Feb.
Article in Russian | MEDLINE | ID: mdl-2344956

ABSTRACT

Genogeography as a field of interdisciplinar investigation was introduced into science in 1928 by Russian geneticist A. S. Serebrovsky an today is well known in human genetics as gene geography. This work was undertaken to introduce a new method of computer cartography of gene frequencies in human and in any other populations. The method is different from known one of P. Menozzi, A. Piazza and L. Cavalli-Sforza. Two key moments of the method are principle of fusion-fission of gene in the homogeneous geographical space equally free-for-all human genes, and principle of local-linear (but not of the high-orders) interpolation of gene frequencies onto spheric surface of geographical space. Such procedure was used for mapping of human AB0-B gene frequencies among native populations of Central Asia.


Subject(s)
ABO Blood-Group System/genetics , Computer Simulation , Genetics, Medical , Genetics, Population , Gene Frequency , Humans , Mongolia/ethnology
3.
Genetika ; 21(8): 1368-71, 1985 Aug.
Article in Russian | MEDLINE | ID: mdl-4054617

ABSTRACT

The secretory status of ABH antigens is studied in khotons (N = 69), inhabitants of North-West of MPR. The proportion of nonsecretory ABH antigens was 14.49%, the frequency of recessive gene being qse = 3807. The results confirm the historical evidence concerning the contribution of different peoples of Central and Middle Asia (uzbeks, uigurs) to the ethnogenesis of the khotons. The position of the khoton population on the genogeographical map of ABH secretion corresponds to that which was earlier predicted by the method of interpolation.


Subject(s)
ABO Blood-Group System/genetics , Ethnicity , Polymorphism, Genetic , ABO Blood-Group System/immunology , Gene Frequency , Genetics, Population , Humans , Mongolia , Phenotype , Saliva/immunology
4.
Genetika ; 21(4): 658-63, 1985 Apr.
Article in Russian | MEDLINE | ID: mdl-4007487

ABSTRACT

A variant of the vertical polyacrylamide gel electrophoresis method, hitherto not applied in determination of C'3, is used. The method allows simultaneous determination of the C'3 phenotypes and other serum proteins in human blood. In this paper, the influence of aging of the serum samples and of the Tf polymorphism on the C'3 electrophoregram is discussed. The gene frequencies in Mongolian population (MPR) are: C'3S = 0.9605, C'3F = 0.0375, and the rare variants C'3Srare = 0.0013, C'3Frare = 0.0007; in Chukchi these are 1.0, 0.0, 0.0, respectively; in Eskimos - 0.9556, 0.0222, 0.0111; Evenki - 0.9359, 0.0641, 0.0; Yakuts - 0.9091, 0.0909, 0.0; Komi-Zyrians - 0.8507, 0.1493, 0.0; Komi-Permiyak - 0.8176, 0.1698, 0.0068.


Subject(s)
Complement C3/genetics , Polymorphism, Genetic , Alleles , Asian People , Complement C3/analysis , Electrophoresis, Polyacrylamide Gel/methods , Ethnicity , Gene Frequency , Humans , Mongolia , Phenotype , Siberia , Transferrin/analysis , Transferrin/genetics
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