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J Immunol ; 171(1): 22-6, 2003 Jul 01.
Article in English | MEDLINE | ID: mdl-12816978

ABSTRACT

Class I MHC molecules bind intracellular peptides for presentation to cytotoxic T lymphocytes. Identification of peptides presented by class I molecules during infection is therefore a priority for detecting and targeting intracellular pathogens. To understand which host-encoded peptides distinguish HIV-infected cells, we have developed a mass spectrometric approach to characterize HLA-B*0702 peptides unique to or up-regulated on infected T cells. In this study, we identify 15 host proteins that are differentially presented on infected human T cells. Peptides with increased expression on HIV-infected cells were derived from multiple categories of cellular proteins including RNA binding proteins and cell cycle regulatory proteins. Therefore, comprehensive analysis of the B*0702 peptide repertoire demonstrates that marked differences in host protein presentation occur after HIV infection.


Subject(s)
Antigen Presentation/immunology , HIV/immunology , HLA-B Antigens/metabolism , Peptide Fragments/metabolism , T-Lymphocyte Subsets/metabolism , T-Lymphocyte Subsets/virology , HIV Infections/immunology , HIV Infections/metabolism , HIV Infections/virology , HLA-B Antigens/immunology , Humans , Mass Spectrometry , Peptide Fragments/immunology , Peptide Fragments/isolation & purification , Peptide Mapping , T-Lymphocyte Subsets/immunology , Transfection , Tumor Cells, Cultured
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