ABSTRACT
BACKGROUND: Nasal polyposis is a chronic inflammation of nasal and paranasal sinuses in the pathogenesis of which adhesion molecules may have a significant role. This study investigates the possible role of certain adhesion molecules, mucins, and oncogenes in nasal polyposis recurrence. METHODS: A sample study of 21 individuals (17 men and 4 women) aged 47.44 ± 15.10 years with nasal polyposis who had undergone nasal surgery twice was used. Twenty-one individuals aged 46.9 ± 12.8 years suffering from nasal polyposis who had undergone surgery only once in the same period were used as a control sample. RESULTS: Statistically significant differences between the two groups were observed regarding epithelial membrane antigen (EMA/mucin 1) of stromal cells (p < 0.001) and CD86 stromal expression (p = 0.009). No patient of the control group exhibited high (++) CD86 stromal expression, whereas six patients of the resurgery group did so. When EMA and CD86 were included in a logistic regression model, stromal EMA was found to be positively related to recurrence. CONCLUSION: Adhesion molecules may relate to nasal polyp prognosis and recurrence rates.
Subject(s)
B7-2 Antigen/metabolism , Cell Adhesion Molecules/metabolism , Nasal Polyps/diagnosis , Paranasal Sinuses/pathology , Stromal Cells/metabolism , Adult , Female , Humans , Male , Middle Aged , Mucin-1/metabolism , Predictive Value of Tests , Prognosis , RecurrenceABSTRACT
Nasal actinomycosis is a rare disease. We present a case of nasal actinomycosis causing symptoms similar to those of a nasal foreign body. A 34-year-old woman presented with a long history of halitosis and unilateral offensive, purulent rhinorrhea. Rigid nasendoscopy showed a hard, dark gray mass between the middle and inferior turbinates. Computed tomography findings were typical of a nasal foreign body. Endoscopic removal of the mass was performed, and histopathology established a diagnosis of actinomycosis. We suggest that every clinician confronted with unilateral nasal symptoms and/or signs should have this clinical entity in mind, since it has justifiably been characterized as the head and neck "mimic."
Subject(s)
Actinomycosis/diagnosis , Foreign Bodies/diagnosis , Nose Diseases/diagnosis , Actinomycosis/complications , Adult , Diagnosis, Differential , Endoscopy , Female , Humans , Nasal Obstruction/etiology , Nose Diseases/complicationsABSTRACT
The occurrence of sialoliths in the submandibular gland is 80% due to the specific anatomy of both the gland and its duct. The diagnosis is rather easy because of the obvious clinical signs of the entity. Imaging studies are always necessary in order to treat the patient as effectively as possible. The stones do not tend to occur within the gland as frequently as in the respective duct. The coexistence of sialoliths and malignant tumors is extremely rare. A 70-year-old woman with intraparenchymal stone was operated in our ENT department. In addition to the sialolith the pathological examination revealed the existence of an adenoid cystic carcinoma (ACC), that extended to the neighboring skeletal muscle. This is the reason why we believe it would be useful to report this case of a large stone (14 mm in diameter) located in the submandibular gland coexisting with ACC. This case report is a very good example illustrating that all available means should be used prior to reaching a conclusion and making a health professional decision.
Subject(s)
Carcinoma, Adenoid Cystic/complications , Salivary Gland Calculi/complications , Submandibular Gland Neoplasms/complications , Aged , Female , HumansABSTRACT
No disponible
Ôhe occurrence of sialoliths in the submandibular gland is 80% due to the specific anatomy of both the gland and its duct. The diagnosis is rather easy because of the obvious clinical signs of the entity. Imaging studies are always necessary in order to treat the patient as effectively as possible. The stones do not tend to occur within the gland as frequently as in the respective duct. The coexistence of sialoliths and malignant tumors is extremely rare. A 70-year-old woman with intraparenchymal stone was operated in our ENT department. In addition to the sialolith the pathological examination revealed the existence of an adenoid cystic carcinoma (ACC), that extended to the neighboring skeletal muscle. This is the reason why we believe it would be useful to report this case of a large stone (14 mm in diameter) located in the submandibular gland coexisting with ACC. This case report is a very good example illustrating that all available means should be used prior to reaching a conclusion and making a health professional decision
