ABSTRACT
INTRODUCTION: In routine medical practice, the diagnosis of aspirin hypersensitivity (AH) remains difficult. No clinical feature or biomarker is available to reliably confirm this diagnosis and oral provocation tests (OPT) are rarely performed. AIM: To compare asthmatics with and without AH. METHOD: The clinical characteristics of 21 asthmatics with and 24 without AH respectively were determined. AH was defined by a positive OPT. A full blood count was done before and 24 hours after the OPT. RESULTS: The medical history was associated with a weak sensitivity (52%) and a good specificity (96%) for assessing the diagnosis of AH. There was a higher prevalence of AH in women, and a higher frequency of allergic rhinitis in AH, but no characteristic was useful to facilitate the diagnosis of AH in asthmatic patients. Our results demonstrate higher values of platelets in AH patients. Following OPT, in AH patients only, a decrease in blood eosinophils and an increase in neutrophils was observed. CONCLUSIONS: These results confirm that the diagnosis of AH is challenging, with the history having only weak sensitivity. The observation that fluctuations in eosinophils and neutrophils occur following OPT in AH patients only warrants further investigations and suggests a rapid pro-inflammatory role for aspirin.
Subject(s)
Aspirin/adverse effects , Drug Hypersensitivity/diagnosis , Adult , Aged , Anti-Asthmatic Agents/therapeutic use , Aspirin/immunology , Asthma/diagnosis , Asthma/drug therapy , Asthma/epidemiology , Blood Cell Count , Blood Platelets/drug effects , Comorbidity , Diagnosis, Differential , Drug Hypersensitivity/epidemiology , Eosinophils/drug effects , Female , Humans , Male , Medical History Taking , Middle Aged , Nasal Polyps/diagnosis , Nasal Polyps/epidemiology , Neutrophils/drug effects , Prospective Studies , Respiratory Hypersensitivity/chemically induced , Rhinitis, Allergic, Perennial/diagnosis , Rhinitis, Allergic, Perennial/epidemiology , Sensitivity and Specificity , Sex Distribution , Young AdultABSTRACT
INTRODUCTION: Synovial sarcoma is an uncommon tumour and thoracic involvement is rare and of varying location. Clinical characteristics are dominated by pain, with a slow progression over years. Pathological and immuno-histochemical characteristics are helpful in the diagnosis but a specific translocation between chromosomes X and 18 is crucial for confirmation. Extensive surgical resection is required for cure, combined with adjuvant radiotherapy in the presence of adverse prognostic factors. CASE REPORT: We report a case of synovial sarcoma of the chest wall, responsible for chronic local pain for several years, presenting as an acute pleuropneumonitis in a 21-year-old patient. In view of the large size of the tumour, associated with a high proliferation index (Ki-67), a surgical resection was performed, together with local adjuvant radiotherapy. CONCLUSION: This case report reviews synovial sarcoma and underlines the difficulties and requirements of both diagnostic strategy and therapeutic management. Among them, an initial systematic review of prognostic factors (tumour size, mitotic activity, proliferation index, SYT-SSX type fusion, histological grade) is crucial to determine the therapeutic options.
Subject(s)
Sarcoma, Synovial/diagnosis , Thoracic Neoplasms/diagnosis , Thoracic Wall , Biomarkers, Tumor/analysis , Combined Modality Therapy , Diagnosis, Differential , Follow-Up Studies , Humans , Lymph Node Excision , Magnetic Resonance Imaging , Male , Neoplasm Invasiveness , Pleuropneumonia/diagnosis , Pleuropneumonia/pathology , Pneumonectomy , Prognosis , Radiotherapy, Adjuvant , Sarcoma, Synovial/pathology , Sarcoma, Synovial/radiotherapy , Sarcoma, Synovial/surgery , Smoking/adverse effects , Thoracic Neoplasms/pathology , Thoracic Neoplasms/radiotherapy , Thoracic Neoplasms/surgery , Thoracic Wall/pathology , Thoracic Wall/surgery , Thoracotomy , Young AdultABSTRACT
INTRODUCTION: In western countries, community-acquired pneumonias due to Klebsiella pneumoniae (Kp) are rare and associated with a poor prognosis and a high mortality. The severity is in part linked to the virulence of Kp. Immuno-depression, sepsis and visceral abscesses are frequently found, constituting other classical risk factors for severity and contributing to the poor prognosis. The therapeutic strategy is based on third generation cephalosporins, aminoglycosides and quinolones. CASE REPORT: We report the case of a young adult, with undiagnosed diabetes, hospitalized as an emergency for septic shock complicating a community-acquired pneumonia due to Kp and associated with multiple brain and lung abscesses. After several weeks of treatment, initially with empirical then specific antibiotics, a favourable outcome was obtained. CONCLUSION: This case report underlines the particular severity of infections due to Kp and their main pathophysiological mechanisms. It is also an opportunity to highlight the potential responsibility of Kp in the presence of a pneumonia with lung abscesses and finally to update the principles of antibiotic therapy.