Strong dissipation inhibits losses and induces correlations in cold molecular gases.

Atomic quantum gases in the strong-correlation regime offer unique possibilities to explore a variety of many-body quantum phenomena. Reaching this regime has usually required both strong elastic and weak inelastic interactions because the latter produce losses. We show that strong inelastic collisions can actually inhibit particle losses and drive a system into a strongly correlated regime. Studying the dynamics of ultracold molecules in an optical lattice confined to one dimension, we show that the particle loss rate is reduced by a factor of 10. Adding a lattice along the one dimension increases the reduction to a factor of 2000. Our results open the possibility to observe exotic quantum many-body phenomena with systems that suffer from strong inelastic collisions.

Atom-molecule Rabi oscillations in a Mott insulator.

We observe large-amplitude Rabi oscillations between an atomic and a molecular state near a Feshbach resonance. The experiment uses 87Rb in an optical lattice and a Feshbach resonance near 414 G. The frequency and amplitude of the oscillations depend on the magnetic field in a way that is well described by a two-level model. The observed density dependence of the oscillation frequency agrees with theoretical expectations. We confirmed that the state produced after a half-cycle contains exactly one molecule at each lattice site. In addition, we show that, for energies in a gap of the lattice band structure, the molecules cannot dissociate.

Identification and molecular cloning of two new 30-kDa insulin-like growth factor binding proteins isolated from adult human serum.

Three insulin-like growth factor binding proteins (IGFBP) with apparent molecular masses of 24, 28-30, and 30 kDa, nonreduced, have been isolated from human serum. The 15 NH2-terminal amino acids of the 24-kDa binding protein are identical with those of the 30-kDa BP. The apparent molecular mass of the latter is reduced to 24 kDa by N-glycanase, suggesting that the 30-kDa BP is the glycosylated form of the isolated 24-kDa BP. The complete amino acid sequences derived from the cloned cDNAs represent two new IGFBPs. They are tentatively termed IGFBP-4 and -5. The prepeptide sequences of BP-4 and -5 contain 27 and 21, the mature proteins 213 and 237 amino acids, respectively (Mr = 22,610 and 25,980). The NH2- and COOH-terminal thirds of BP-4 and -5 display pronounced homology to the other three human BPs. 16 of the 16-20 cysteines and 37 of the 213-289 amino acids (12.8-17.1%) are conserved in all five mature BPs. 10 amino acid positions located in the NH2-terminal region and shared by BP-1, -2, -3, and -5 are different in BP-4. These differences may account for the preferential affinity of BP-4 for IGF II. A most intriguing homology exists between the COOH-terminal quarter of the five IGFBPs, 10 repetitive domains of human thyroglobulin, a gastrointestinal tumor-associated antigen, and the invariant chain of the class II histocompatibility antigen. The cDNAs of five human IGFBPs are now available. They will allow their expression and production in sufficient quantities for in vivo studies to unravel their role in growth and metabolism.

A comparative analysis of several crutch-length-estimation techniques.

The purpose of this study was to determine which of several crutch-fitting techniques best predicts ideal crutch length. One hundred seven active-duty military volunteers were measured for crutches using each of the following methods: (1) axillary fold to heel in the supine position, (2) olecranon to opposite third fingertip, (3) olecranon to opposite fifth fingertip, (4) 77% of height, (5) height minus 16 in (40.6 cm), (6) 77% of arm span, and (7) arm span minus 16 in (40.6 cm). The subject's self-reported heights and their actual measured heights were both used in calculations involving height. Ideal crutch length was determined by an experienced orthopedic physical therapist, with placement of the axillary pad 2.5 in (6.4 cm) below the axillary fold. Mean squared error indices were then computed as the average of the squared deviations of the technique measurements from the ideal crutch length. Of the techniques studied, the two involving minor arithmetical adjustments to the subjects' self-reported height were found to be good predictors: 77% of height and height minus 16 in (40.6 cm). The poorest predictor was axilla to heel in the supine position. Finally, two additional length estimates were derived using linear regression analyses. These estimates provided the best overall predictions based on actual height and reported height. A quick-reference table for crutch-length estimates based on patient heights was developed from these regression results.

Molecular cloning of a new human insulin-like growth factor binding protein.

We have cloned a new insulin-like growth factor's binding protein (IGFBP) from a human osteosarcoma cDNA library. Two conserved regions in the COOH-terminal third of the five known human IGFBPs were used to design primers and to perform polymerase chain reaction (PCR) with osteosarcoma cDNA as a template. One of the eight PCR products encoded a unique IGFBP sequence. The DNA sequence was used to synthesize probes to screen an osteosarcoma cDNA library and isolate full length cDNA clones. The amino acid sequence was deduced from one of them. It contains two possible signal peptidase cleavage sites yielding a mature molecule of 257 or 252 amino acids, and 18 cysteines in identical positions to the other IGFBPs. The most pronounced homology exists with human IGFBP-3 (50% in the NH2- and 45% in the COOH-terminal region).