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Pharmaceutical Composition for Improving Physical Working Capacity.

Baulin, S I; Rogacheva, S M; Afanaseva, S V; Zabanova, E V; Karagaycheva, Yu V.

Bull Exp Biol Med ; 160(1): 45-8, 2015 Nov.

Article in English | MEDLINE | ID: mdl-26601841

ABSTRACT

For development of a pharmaceutical composition improving physical performance, effects of various drugs and their combinations on forced swimming test performance were studied on laboratory rats. Maximum increase in animal performance was produced by a 3-component composition asparcam+mildronate+metaprote in proportion of 5.0, 10.7, and 14.3 mg/kg, respectively. No changes in blood serum biochemistry and morphological composition of the peripheral blood were detected after single intragastric administration of the composition.

Subject(s)

Antioxidants/pharmacology , Aspartic Acid/pharmacology , Benzimidazoles/pharmacology , Central Nervous System Stimulants/pharmacology , Methylhydrazines/pharmacology , Performance-Enhancing Substances/pharmacology , Physical Endurance/drug effects , Adenosine Triphosphate/metabolism , Animals , Antioxidants/administration & dosage , Aspartic Acid/administration & dosage , Athletic Performance , Benzimidazoles/administration & dosage , Central Nervous System Stimulants/administration & dosage , Drug Combinations , Drug Evaluation, Preclinical , Drug Synergism , Ecdysterone/administration & dosage , Ecdysterone/pharmacology , Energy Metabolism/drug effects , Methylhydrazines/administration & dosage , Performance-Enhancing Substances/administration & dosage , Phenytoin/administration & dosage , Phenytoin/pharmacology , Proteins/metabolism , Rats , Swimming , Weight-Bearing

Effects of drugs on exercise performance.

Baulin, S I; Rogacheva, S M; Afanaseva, S V.

Bull Exp Biol Med ; 155(5): 636-8, 2013 Sep.

Article in English | MEDLINE | ID: mdl-24288727

ABSTRACT

The effects of 15 preparations with general tonic, antioxidant, and antihypoxant activities on exercise performance of laboratory rats were studied in the forced swimming test. The best recovery and improvement of exercise performance was recorded after a single intragastric dose of schizandrin and acyzol. These drugs stimulated an increase in the parameters in control animals by 86 and 72% (exercise performance recovery) and by 33 and 51% (exercise performance improvement).

Subject(s)

Antioxidants/pharmacology , Central Nervous System Stimulants/pharmacology , Cyclooctanes/pharmacology , Imidazoles/pharmacology , Lignans/pharmacology , Organometallic Compounds/pharmacology , Physical Endurance/drug effects , Polycyclic Compounds/pharmacology , Administration, Oral , Animals , Animals, Outbred Strains , Oxidative Stress/drug effects , Physical Conditioning, Animal , Physical Endurance/physiology , Rats , Swimming

[The effect of halogenated dibenzo-p-dioxins on the growth of grasses and assessment of the danger of contaminated phytomasses for mammals]. / Vliianie galoidirovannykh dibenzo-p-dioksinov na rost travianistoi rastitel'nosti i otsenka opasnosti zarazhennoi fitomassy dlia mlekopitaiushchikh.

Kuntsevich, A D; Golovkov, V F; Chernov, S A; Baulin, S I; Troshkin, N M; Rembovskii, V R.

Dokl Akad Nauk ; 341(5): 693-5, 1995 Apr.

Article in Russian | MEDLINE | ID: mdl-7787787

Subject(s)

Poaceae/drug effects , Polychlorinated Dibenzodioxins/toxicity , Soil Pollutants/toxicity , Animals , Female , Guinea Pigs , Lethal Dose 50 , Male , Mammals , Poaceae/growth & development

[Species-specific toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin upon the acute and chronic effect on the mammalian body]. / Vidovaia taksichnost' 2,3,7,8-tetrakhlordibenzo-p-dioksina pri ostrom i khronicheskom vozdeistvii na organizm mlekopitaiushchikh.

Kuntsevich, A D; Troshkin, N M; Baulin, S I; Golovkov, V F; Nedoshivin, Iu K; Rembovskii, V R.

Dokl Akad Nauk ; 340(2): 268-70, 1995 Jan.

Article in Russian | MEDLINE | ID: mdl-7703891

Subject(s)

Polychlorinated Dibenzodioxins/poisoning , Acute Disease , Animals , Body Weight/drug effects , Chronic Disease , Lethal Dose 50 , Poisoning/physiopathology , Species Specificity , Weight Loss/drug effects

[Comparative analysis of changes in protein and fat metabolism, lipid peroxidation, and the hemostasis system under the action of polychlorinated dibenzo-p-dioxins and radiation]. / Sravnitel'nyi analiz izmenenii belkovogo i zhirovogo obmena, perekisnogo obmena, perekisnogo okisleniia lipidov i sistemy gemostaza pri deistvii polikhlorirovannykh dibenzo-p-dioksinov i radiatsii.

Kuntsevich, A D; Baulin, S I; Golovkov, V F; Rembovskii, V R; Smirnova, L A; Troshkin, N M.

Dokl Akad Nauk ; 335(3): 378-81, 1994 Mar.

Article in Russian | MEDLINE | ID: mdl-8186749

Subject(s)

Fats/metabolism , Hemostasis/drug effects , Hemostasis/radiation effects , Lipid Peroxidation/drug effects , Lipid Peroxidation/radiation effects , Polychlorinated Dibenzodioxins/pharmacology , Proteins/metabolism , Animals , Female , Male , Radiation Injuries, Experimental/metabolism , Rats

[Toxic effects of the combined action of ionizing radiation and halogenated dibenzo-p-dioxins on mammals]. / Toksicheskie éffekty kombinirovannogo deistviia ioniziruiushchego izlucheniia i galoidirovannykh dibenzo-p-dioksinov na organizm mlekopitaiushchikh.

Kuntsevich, A D; Baulin, S I; Golovkov, V F; Rembovskii, V R; Troshkin, N M.

Dokl Akad Nauk ; 331(3): 369-71, 1993 Jul.

Article in Russian | MEDLINE | ID: mdl-8364389

Subject(s)

Polychlorinated Dibenzodioxins/toxicity , Radiation Injuries, Experimental , Animals , Lethal Dose 50 , Mammals , Mice , Radiation, Ionizing

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