[Ocular blood flow of cats after local administration of pilocarpine, phenylephrine, and of a mixture of both drugs (author's transl)]. / Die Durchblutung des Katzenauges unter lokaler Verabreichung von Pilocarpin, Phenylephrin und einer Kombination beider Pharmaka.

Radioactively labelled microspheres (size 15 micron) were used to determine the regional blood flow in cats before and 15, 30 and 45 minutes after unilateral drug administration. In four experimental groups, each consisting of five animals, two drops of the drug were administered into the conjunctival sac. The blood flow increased in both eyes after administration of 2% pilocarpine and of Glauko Biciron, a mixture of 2% pilocarpine and 0.06% phenylephrine. No significant differences in the regional blood flows between the treated and untreated eye were found. After administration of 2% phenylephrine a decrease in blood flow was observed in both eyes, however earlier and more pronounced in the left eye. Thus, phenylephrine evoked the expected vasoconstrictive effect on the treated side. In the control group, which received physiological salt solution, the blood flow on the treated side decreased in most tissues, while an increase was observed on the untreated side.

[Blood flow through different tissues under clonidine in rabbits (author's transl)]. / Die Durchblutung verschiedener Gewebe des Kaninchens unter Clonidin

The effect of i.v. administered clonidine on the blood flow through different tissues was investigated in six rabbits which had been anaesthetized with NembutalR. Six additional animals served as controls and received an equal quantity of a physiological sodium chloride solution. The blood flow was determined by means of radioactively labelled microspheres just before as well as 15, 30 and 45 min after the administration of the drug or the placebo respectively. In most of the investigated tissues a considerable decrease in blood flow was observed 15 min after the injection of clonidine, whereas no effect was to be seen after administration of sodium chloride. For the first time after 30 min, and even more after 45 min the blood flow diminished as well in the control group. The flow-decreasing effect of clonidine occured in lung, skin, choroid, the small intestine, the triceps muscle, the ciliary body, iris, and white matter, whereas the opposite reaction was observed in liver (hepatic artery), retina and the optic nerve.