1.
Microbiol Immunol
; 42(6): 471-3, 1998.
Article
in English
| MEDLINE
| ID: mdl-9688082
ABSTRACT
The short-term kinetics of infectious HIV titers, HIV copy numbers and p24-antigen during the first 28 days of AZT monotherapy were evaluated. In three of four patients, infectious HIV was culturable and infectious titers rose 2- and 4-fold compared to baseline values. This increase was neither associated with mutations conferring resistance to AZT nor a switch from NSI to SI phenotypes. Two patients showed an increase of plasma infectivity associated with a reduction of HIV copies and p24-antigen. We conclude that transient dissociations of plasma infectivity and HIV copy numbers occur during early AZT monotherapy.
Subject(s)
Anti-HIV Agents/therapeutic use , HIV Infections/drug therapy , HIV-1/physiology , RNA, Viral/blood , Viremia/virology , Zidovudine/therapeutic use , Adult , Enzyme-Linked Immunosorbent Assay , Female , HIV Core Protein p24/blood , HIV Infections/virology , HIV-1/isolation & purification , Humans , Male , Prospective Studies , Time Factors
2.
AIDS
; 10(13): 1600-1, 1996 Nov.
Article
in English
| MEDLINE
| ID: mdl-8931801