1.
J Antimicrob Chemother
; 41(5): 505-12, 1998 May.
Article
in English
| MEDLINE
| ID: mdl-9630404
ABSTRACT
Macrolides are unique among the various classes of antimicrobial agents because of the manner in which they interact with pathogens and the host immune system to produce a clinical response. Conventional efficacy explanations require the serum or tissue concentration of the macrolide to exceed the MIC of the macrolide to account for bacteriostatic activity. However, at concentrations below the MIC, there are other effects on the expression of proteinaceous virulence factors which could prevent the pathogen from establishing or expanding an infection. The purpose of this review is to describe these effects and to provide an in-vivo scenario delineating the role of macrolides and leucocytes as they contribute to clinical efficacy.
Subject(s)
Anti-Bacterial Agents/pharmacology , Bacteria/drug effects , Anti-Bacterial Agents/therapeutic use , Bacteria/enzymology , Bacteria/pathogenicity , Bacteria/ultrastructure , Bacterial Adhesion/drug effects , Bacterial Infections/blood , Bacterial Infections/drug therapy , Bacterial Infections/microbiology , Bacterial Toxins/metabolism , Blood Bactericidal Activity/drug effects , Humans , Leukocytes/drug effects , Leukocytes/microbiology , Macrolides , Virulence
2.
Int J Dermatol
; 36(2): 90-6, 1997 Feb.
Article
in English
| MEDLINE
| ID: mdl-9109002