[Digitization and image reconstruction: application to iconography of surgical pathology specimens]. / Numérisation et traitement informatique de l'image: application à l'iconographie des pièces opératoires en anatomie pathologique.

A simple method for obtaining imaging documents of surgical specimens is reported. the method uses a scanner and a personal computer with printer. It provides rapid, low-cost high-quality images on paper or transparencies. The document can be used to illustrate a pathology report or discussion between clinicians and pathologists. The computers facilities already present in most Pathology laboratories is sufficient. The scanner with software cost slightly more than a camera.

[Immunohistochemical evaluation of estrogen and progesterone receptors on paraffin sections of breast carcinomas. Practical thoughts based on the study of 368 cases]. / Evaluation immunohistochimique des récepteurs aux estrogènes et à la progestérone sur coupes en paraffine de carcinomes mammaires. Réflexions pratiques suscitées par l'étude de 368 cas.

368 formalin-fixed and paraffin-embedded carcinomas of the breast were studied by immunohistochemistry using antibodies to estrogen and progesterone receptors. The results, which are comparable to the results published in the literature, are discussed with particular emphasis on quality assurance parameters.

[Small intestinal tumors with skeinoid fibers. Report of 3 cases with immunohistochemical and ultrastructural study]. / Tumeurs de l'intestin grêle avec fibres en écheveau. 3 observations avec étude immunohistochimique et ultrastructurale.

Three cases of small intestinal stromal tumors with skeinoid fibers are presented and are confronted to the 15 cases found in the literature. These tumors are characterized by the presence of intercellular eosinophilic globules that stain positively on periodic acid-Schiff stain. Ultrastructurally, these structures are composed of tangles of curved banded (45 nm) fibers simulating an appearance of skeins. By immunohistochemistry, tumor cells express vimentin only. These tumors seem to be derived from the enteric plexus.

Neuroendocrine carcinoma (Merkel cell tumor?) presenting as a subcutaneous tumor. An ultrastructural and immunohistochemical study of three cases.

The clinical and pathological features of three unusual soft tissue tumors are presented. They occurred in the groin of elderly patients in the subcutaneous tissue. In Case 1, the inguino-crural tumor coexisted with a second mass in the pelvis. The tumors had a tendency to recur locally and to invade the regional lymph nodes. Metastatic dissemination of the disease resulted in the death of the patient in Case 3. Histologically, the tumors appeared composed of small round cells with scanty cytoplasms, arranged in diffuse, poorly cohesive or solid sheets. In places, a trabecular pattern was noted. Mitotic figures were numerous. Some cells exhibited argyrophil granules. The ultrastructural study revealed compact whorls of intermediate filaments and neurosecretory granules. All three cases displayed a paranuclear dot-like positive reaction with antibodies to cytokeratins and neurofilaments. A diffuse cytoplasmic immunostaining for neuron-specific enolase was present in Cases 1 and 2. Protein S-100, vimentin and leucocyte common antigen could not be demonstrated. All these characteristics, except for the subcutaneous location, are shared with neuroendocrine (Merkel cell) tumors of the skin.

Distinction between hepatocellular carcinoma, cholangiocarcinoma, and metastatic carcinoma based on immunohistochemical staining for carcinoembryonic antigen and for cytokeratin 19 on paraffin sections.

An antiserum to carcinoembryonic antigen (CEA) and a monoclonal antibody to cytokeratin 19 (CK 19) were studied for their suitability as diagnostic reagents for the differential diagnosis of primary and secondary malignant epithelial tumours of the liver, on paraffin sections. With the antiserum to CEA, positive bile canalicular structures were found in 60 per cent of the hepatocellular carcinomas. All the cholangiocarcinomas and 66.6 per cent of the metastatic carcinomas were positive for CEA, without displaying a canalicular staining pattern. All the hepatocellular carcinomas were negative for CK 19. All the cholangiocellular carcinomas and the metastatic carcinomas were positive for CK 19. This staining profile may prove helpful in difficult diagnostic cases.

Plexiform tumorlet of the uterus: immunohistological evidence for a smooth muscle origin.

A case of plexiform tumorlet of the uterus is reported and studied histologically and by immunohistochemistry. The presence of desmin in the tumour cells demonstrates their smooth muscle origin. These results are compared with other reports in the literature with special emphasis on histogenesis.

[Benign lesions of the hand simulating angiosarcoma: Masson's vegetating intravascular hemangioendothelioma]. / Lésions bénignes de la main simulant un angiosarcome: l'hémangio-endothéliome végétant intravasculaire de Masson.

The authors report a case of intravascular hemangio-epithelioma vegetans of Masson. Usually a tumor of the head and neck. This case was characterized by the presence of two independent tumors on the same hand. On the cases of the 86 cases reported in the world literature, the authors suggest a primary endothelial origin for this benign tumor.