Subject(s)
Appendectomy , Appendicitis , Acute Disease , Anti-Bacterial Agents , Humans , Retrospective Studies , Treatment OutcomeABSTRACT
Golimumab is a human IgG monoclonal antibody specific for human tumor necrosis factor alpha. Golimumab has been approved for use in rheumatological conditions; however, its use in inflammatory bowel disease is still being evaluated in clinical trials. We report a case of an exacerbation of ulcerative proctitis after starting on golimumab for ankylosing spondylitis.
Subject(s)
Antibodies, Monoclonal/adverse effects , Antibodies, Monoclonal/therapeutic use , Inflammatory Bowel Diseases/chemically induced , Spondylitis, Ankylosing/drug therapy , Adalimumab , Adult , Antibodies, Monoclonal, Humanized/therapeutic use , Diarrhea/chemically induced , Humans , Inflammatory Bowel Diseases/pathology , Male , Proctitis/chemically induced , Proctitis/pathology , Spondylitis, Ankylosing/complications , Tumor Necrosis Factor-alpha/antagonists & inhibitorsABSTRACT
Multidrug resistant pneumonia is an entity, which is difficult to treat, and in a patient with acute renal insufficiency, it leaves a physician with a handful of antibiotics to be considered. Aerosolized administration of antibiotics is one option that can be contemplated for a patient with acute renal insufficiency to avoid the nephrotoxic effect of the antibiotics.
Subject(s)
Acute Kidney Injury/physiopathology , Amikacin/therapeutic use , Anti-Bacterial Agents/therapeutic use , Pneumonia, Bacterial/drug therapy , Administration, Inhalation , Aerosols , Amikacin/administration & dosage , Amikacin/adverse effects , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/adverse effects , Drug Resistance, Multiple, Bacterial , Female , Humans , Middle Aged , Pneumonia, Bacterial/microbiologyABSTRACT
The incidence of drug-related acute liver failure is approximately 14 per 100,000 populations. Drug-induced liver injury may take place through a variety of mechanism. Withdrawal of the offending agent may result in complete recovery. Clindamycin is known to cause mild derangement of liver function; however, acute liver injury causing severe derangement of liver function associated with encephalopathy is uncommon.
Subject(s)
Anti-Bacterial Agents/adverse effects , Chemical and Drug Induced Liver Injury/epidemiology , Clindamycin/adverse effects , Cognitive Dysfunction/epidemiology , Liver Failure, Acute/chemically induced , Aged , Humans , MaleABSTRACT
Caroli's syndrome is characterized by bile duct ectasia in association with hepatic fibrosis. It is usually transmitted in an autosomal recessive fashion and has been well documented to be associated with autosomal recessive polycystic kidney disease and occasionally with autosomal dominant polycystic kidney disease. However, there has been only few case reports published with Caroli's syndrome diagnosed postrenal transplantation.
Subject(s)
Caroli Disease/diagnosis , Kidney Transplantation , Caroli Disease/therapy , Diagnostic Imaging , Humans , Liver Function Tests , Male , Middle AgedABSTRACT
Management of soft tissue sarcomas can be very challenging because they have a high rate of metastasis, especially to the lungs, and respond very poorly to the currently available chemotherapeutic drugs. We present a case of epithelioid sarcoma in which complete remission of pulmonary metastases was observed after treatment with a single agent, navelbine, a vinca alkaloid, and a potential therapeutic agent. The patient has been persistently free of metastases for 4 years since treatment with navelbine. Further studies are warranted to establish the role of navelbine for the treatment of soft tissue sarcoma and their metastases.
Subject(s)
Antineoplastic Agents, Phytogenic/therapeutic use , Lung Neoplasms/drug therapy , Lung Neoplasms/secondary , Sarcoma/drug therapy , Sarcoma/secondary , Vinblastine/analogs & derivatives , Aged , Forearm , Humans , Lung Neoplasms/diagnostic imaging , Male , Multimodal Imaging , Positron-Emission Tomography , Remission Induction/methods , Sarcoma/diagnostic imaging , Tomography, X-Ray Computed , Vinblastine/therapeutic use , VinorelbineABSTRACT
Large perigastric or periduodenal pseudocysts are a potential cause of gastric outlet obstruction, usually requiring interventional drainage of the pseudocysts. In contrary most of the small pseudocysts are asymptomatic and require no therapy. However, certain small pseudocysts can produce clinically significant problem depending on their location. Here we report a case of small pseudocyst (12.0 mm in width) with a unique shape and location causing significant Gastric outlet obstruction treated successfully with endoscopy.
ABSTRACT
Acute mesenteric ischemia has a variety of etiologies. Non-occulusive mesenteric ischemia accounts for 20-30% of patients with acute mesenteric ischemia. We describe a case of non-occulusive jejunal ischemia leading to infarction that occurred in a patient with cirrhosis and no previous history of cardiovascular disease.
