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1.
Cureus ; 15(4): e37057, 2023 Apr.
Article in English | MEDLINE | ID: mdl-37153268

ABSTRACT

Thyroid storm is a life-threatening condition characterized by a high level of circulating thyroid hormones and harbors high mortality and morbidity, even if diagnosed and treated early. The condition is frequently overlooked and under-recognized in emergency departments owing to its rarity. Here, we present a case of a 24-year-old male patient, previously healthy, who presented with cardiac arrest and was found to have heart failure and high thyroid hormone levels after investigations. Consequently, the presentation was attributed to thyroid storm. His clinical status and cardiac function improved after treatment of the hyperthyroidism.

2.
Oncol Lett ; 22(2): 596, 2021 Aug.
Article in English | MEDLINE | ID: mdl-34188698

ABSTRACT

Myxoid liposarcoma (MLPS) is the second most common type of LPS after the well differentiated LPS. MLPS is primarily localized to the extremities. The incidence of LPS is ~2 per million worldwide. MLPS accounts for ~30% of all LPS cases. MLPS is usually encountered in adults, but can also occur in younger individuals more than other types of LPS. MLPS can be divided into low- and high-grade subtypes, which present with differences in patient prognosis and outcome. Methods of tumor management include surgery, radiotherapy and chemotherapy; however, there is no unified treatment based on tumor characteristics alone. The present manuscript reviews the surgical management, radiotherapeutic and chemotherapeutic approaches reported in the literature for different types of MLPS in the extremities, as well as the post-treatment outcomes. In addition, the present review provides an evidence-based management plan for MLPS in the form of an organogram based on specific tumor and patient parameters.

3.
Am J Case Rep ; 20: 719-722, 2019 May 20.
Article in English | MEDLINE | ID: mdl-31105263

ABSTRACT

BACKGROUND Arthrogryposis multiplex congenita is a multifactorial syndromic or non-syndromic group of conditions consisting of multiple congenital contractures of the body, of unknown etiology. It is associated with a heterogenous group of disorders that include but are not limited to processes such as myopathic and neuropathic. Neural tube defect is a neuropathic disorder that incorporates myelomeningocele that might be either isolated or within a spectrum of multiple diseases. CASE REPORT This is a case report of a 28-day-old male born with lower limb arthrogryposis with myelomeningocele and Chiari II malformation in a Mediterranean population. CONCLUSIONS Lower extremity arthrogryposis with myelomeningocele and Chiari II malformation is a prenatal diagnosis that requires high clinical suspicion, early multidisciplinary intervention, and genetic counselling. As long as new approaches are being explored in the management of such cases, babies born now with neural tube defects can expect better quality of life.


Subject(s)
Arnold-Chiari Malformation/diagnosis , Arnold-Chiari Malformation/therapy , Arthrogryposis/diagnosis , Arthrogryposis/therapy , Meningocele/diagnosis , Meningocele/therapy , Arnold-Chiari Malformation/complications , Arthrogryposis/complications , Humans , Infant, Newborn , Male , Meningocele/complications
4.
Epilepsy Behav ; 14(3): 503-7, 2009 Mar.
Article in English | MEDLINE | ID: mdl-19162226

ABSTRACT

Twenty-five consecutive patients who underwent the Wada test using propofol as anesthetic were compared with 15 randomly selected patients who were tested using amobarbital. Time to verbal and nonverbal responses and time to motor power 3/5 did not differ between the two groups (P>0.05). The number of doses received by each patient and the percentage of patients needing more than one dose were significantly greater in the propofol group (P<0.005). Only one patient developed confusion, combativeness, and agitation. Despite the need for multiple doses, our patients had no residual drowsiness within 10 to 15 minutes of the propofol injection. This allowed us to perform the test on both sides on the same day separated only by 45 minutes. Propofol is an effective alternative to amobarbital in the Wada test, and may be used successfully in multiple repeated injections within the same test without significant residual sedation or significant adverse effects.


Subject(s)
Amobarbital , Anesthesia, Intravenous , Anesthetics, Intravenous , Propofol , Adult , Aggression/drug effects , Aggression/psychology , Amobarbital/administration & dosage , Amobarbital/adverse effects , Anesthesia, Intravenous/psychology , Anesthetics, Intravenous/administration & dosage , Anesthetics, Intravenous/adverse effects , Carotid Arteries , Catheterization , Confusion/chemically induced , Confusion/psychology , Electroencephalography/drug effects , Female , Functional Laterality , Humans , Infusions, Intra-Arterial , Magnetic Resonance Imaging , Male , Memory/drug effects , Muscle Strength/drug effects , Propofol/administration & dosage , Propofol/adverse effects , Psychomotor Agitation/psychology , Young Adult
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