ABSTRACT
In this paper, the chiral effective field theory is used to investigate the spin singlet channel [Formula: see text], of proton-proton (pp) scattering according to the new suggested power counting. For this purpose, the pp zero scattering amplitude is reproduced by inserting one pion exchange at leading order (LO) and the Coulomb interaction between protons at next-to-leading order (NLO). This leads to a systematic improvement up to NLO compared to the result obtained from Nijm93 potential model.
ABSTRACT
BACKGROUND: The efficacy of fluconazole (FLU), amphotericin B (AMB) and caspofungin (CAS) was tested against three Candida orthopsilosis, three C. metapsilosis and two C. parapsilosis sensu stricto isolates in neutropenic mice. METHODS: Mice were immunosuppressed by 200 mg/kg cyclophosphamide. Five-day intraperitoneal treatment was started 24 h after infection. Kidney burden was analyzed using the Kruskal-Wallis test. RESULTS: FLU 10 and 20 mg/kg as well as AMB 1 mg/kg significantly decreased the fungal burden (p < 0.05) for all eight isolates of the three species. CAS 2 and 5 mg/kg were efficacious against all C. orthopsilosis and C. metapsilosis isolates (p < 0.05), but only 5 mg/kg CAS was effective against C. parapsilosis isolates (p < 0.05). CONCLUSIONS: The efficacy of FLU and AMB against the three species was comparable. Though the activity of CAS was higher against C. orthopsilosis and C. metapsilosis, the current treatment guidelines for C. parapsilosis sensu stricto seem to be applicable to other 'psilosis' species.
Subject(s)
Amphotericin B/therapeutic use , Antifungal Agents/therapeutic use , Candida/isolation & purification , Echinocandins/therapeutic use , Fluconazole/therapeutic use , Kidney/microbiology , Neutropenia/drug therapy , Amphotericin B/pharmacology , Animals , Antifungal Agents/pharmacology , Candida/drug effects , Caspofungin , Disease Models, Animal , Echinocandins/pharmacology , Female , Fluconazole/pharmacology , Immunocompromised Host , Lipopeptides , Mice , Mice, Inbred BALB C , Microbial Sensitivity Tests , Neutropenia/microbiology , Neutropenia/pathologyABSTRACT
We compared the efficacy of single six mg/kg and 2x3 mg/kg caspofungin doses to the traditional one mg/kg daily against C. albicans in a neutropenic murine model. In lethality experiments, all regimens improved survival (p<0.0014 for all three isolates); differences among the treated groups were not statistically significant. We calculated kidney fungal burdens on each study day for six days postinfection using two isolates in two experiments. In the first three days, only the six mg/kg dose produced significant decrease on all study days (p<0.05-0.001), but differences between the three treatment arms disappeared by 4-6 days postinfection (p<0.05 for all isolates on all days).
