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1.
Andrologia ; 49(6)2017 Aug.
Article in English | MEDLINE | ID: mdl-27681996

ABSTRACT

The purpose of this study was to examine potential long-term post-torsion changes that can occur in the histopathology, biochemistry and spermatogenesis of both torsioned and nontorsioned opposite testes. The study also determines the effect of zinc (Zn) administration on the testicular torsion/detorsion (T/D) damage on both testes. Forty-eight male rats, divided equally into eight groups: (SHAM), (SHAM+,Zn+), (T/D+, Zn- 1 month), (T/D+,Zn- 2 months), (T/D+,Zn- 3 months), (T/D+,Zn+ 1 months), (T/D+,Zn+ 2 months), (T/D+,Zn+ 3 months), have been used. Drug administration was carried out by adding 100 µg (0.016 ml/rat) Zn per rat to drinking water in related groups. Testicular damage decreased superoxide dismutase (SOD) and glutathione (GSH) and increased malondialdehyde (MDA) in the testis tissues of rats, while Zn administration increased SOD and GSH and decreased MDA in the testis tissues in comparison with the SHAM group. The beneficial effect of zinc sulphate was more evident on the nonrotated testis than the rotated testis. In the histopathological study, a significant decrease in torsion and detorsion injuries was observed in the treatment groups compared to the torsion and detorsion groups. We found a protective effect of zinc sulphate on oxidative stress as a result of T/D injuries in rats, especially for the nonrotated testis; results were supported histopathologically.


Subject(s)
Antioxidants/administration & dosage , Oxidative Stress/drug effects , Reperfusion Injury/drug therapy , Spermatic Cord Torsion/drug therapy , Testis/drug effects , Zinc/administration & dosage , Animals , Antioxidants/therapeutic use , Glutathione/metabolism , Male , Malondialdehyde/metabolism , Rats , Rats, Wistar , Reperfusion Injury/metabolism , Reperfusion Injury/pathology , Spermatic Cord Torsion/metabolism , Spermatic Cord Torsion/pathology , Superoxide Dismutase/metabolism , Testis/blood supply , Zinc/therapeutic use
2.
Hum Exp Toxicol ; 35(12): 1252-1263, 2016 Dec.
Article in English | MEDLINE | ID: mdl-26801986

ABSTRACT

Acetaminophen (APAP) overdose could induce liver damage and lead to acute liver failure. The treatment of APAP overdoses could be improved by new therapeutic strategies. Thymus spp., which has many beneficial effects and has been used in folk medicine, is one such potential strategy. In the present study, the hepatoprotective activity of the main constituents of Thymus spp., carvacrol and thymol, were evaluated in light of APAP-induced hepatotoxicity. We hoped to understand the hepatoprotective mechanism of these agents on the antioxidant system and pro-inflammatory cytokines in vitro. Dose-dependent effects of thymol and carvacrol (25, 50, and 100 µM) were tested on cultured HepG2 cells. N-Acetylcysteine (NAC) was tested as positive control. We showed that APAP inhibited HepG2 cell growth by inducing inflammation and oxidative stress. Incubating APAP-exposed HepG2 cells with carvacrol and thymol for 24 h ameliorated this inflammation and oxidative stress. We also evaluated alanine transaminase and lactate dehydrogenase levels of HepG2 cells. We found that thymol and carvacrol protected against APAP-induced toxicity in HepG2 cells by increasing antioxidant activity and reducing pro-inflammatory cytokines, such as tumor necrosis factor α and interleukin 1ß. Taking together high-dose thymol and carvacrol treatment has an effect close to NAC treatment in APAP toxicity, but thymol has better treatment effect than carvacrol.


Subject(s)
Acetaminophen/toxicity , Anti-Inflammatory Agents/pharmacology , Antioxidants/pharmacology , Monoterpenes/pharmacology , Thymol/pharmacology , Anti-Inflammatory Agents/administration & dosage , Antioxidants/administration & dosage , Cell Proliferation/drug effects , Cell Survival/drug effects , Cymenes , Cytokines/genetics , Cytokines/metabolism , Dose-Response Relationship, Drug , Drug Synergism , Gene Expression/drug effects , Hep G2 Cells , Humans , Monoterpenes/administration & dosage , Oxidative Stress/drug effects , Thymol/administration & dosage
3.
Andrologia ; 48(4): 441-52, 2016 May.
Article in English | MEDLINE | ID: mdl-26259852

ABSTRACT

The aim of this study was to examine the effects of amlodipine (AML) in rat testicular torsion/detorsion damage. In this study, rats were divided into eight groups: (i) sham; (ii) testicular ischaemia, 2 h of ischaemia; (iii) testicular ischaemia/reperfusion (I/R), 2 h of ischaemia followed by 2 h of reperfusion; (iv) ischaemia + AML (5 mg kg(-1)) administered 30 min before ischaemia; (v) ischaemia + AML (10 mg kg(-1)) administered 30 min before ischaemia; (vi) and (vii) I/R + AML (5 mg kg(-1)) and I/R + AML (10 mg kg(-1)) administered 1.5 h after the induction of ischaemia, respectively, and at the end of a 2-h ischaemia period and a 2-h reperfusion period applied; and (viii) sham + AML (10 mg kg(-1)). Significant decreases in levels of superoxide dismutase and glutathione were observed in ischaemia and reperfusion groups when compared with healthy controls. These antioxidant levels increased in AML groups while malondialdehyde levels significantly decreased. While increases in tumour necrosis factor-alpha and transforming growth factor-beta levels were found in the torsion and detorsion groups, significant decreases in the levels of these inflammatory cytokines were observed in the treatment groups. These results demonstrate that AML significantly produced protective effects on testis tissue damage that occurs in the torsion/detorsion model via biochemical, histopathological and molecular pathways.


Subject(s)
Amlodipine/pharmacology , Calcium Channel Blockers/pharmacology , Reperfusion Injury/drug therapy , Spermatic Cord Torsion/drug therapy , Testis/drug effects , Administration, Oral , Amlodipine/administration & dosage , Animals , Antioxidants/analysis , Antioxidants/metabolism , Calcium Channel Blockers/administration & dosage , Glutathione/analysis , Glutathione/metabolism , Humans , Male , Malondialdehyde/analysis , Malondialdehyde/metabolism , Oxidative Stress/drug effects , Rats , Rats, Wistar , Reperfusion Injury/metabolism , Reperfusion Injury/pathology , Spermatic Cord Torsion/metabolism , Superoxide Dismutase/analysis , Superoxide Dismutase/metabolism , Testis/metabolism , Testis/pathology , Tumor Necrosis Factor-alpha/analysis
4.
Drug Res (Stuttg) ; 65(5): 272-80, 2015 May.
Article in English | MEDLINE | ID: mdl-24918345

ABSTRACT

BACKGROUND: This study was designed to investigate the protective effects of bosentan an orally active non-peptide mixed ETA/ETB receptor antagonist, on liver injury in streptozotocin-induced diabetic rats. METHODS: 24 Albino-Wistar rats were randomly divided into 4 groups: healthy (Group 1), diabetic (Group 2) (60 mg/kg of streptozotocin i.p.), diabetic treated with bosentan 50 mg/kg (Group 3) and diabetic treated with bosentan 100 mg/kg (Group 4). The treatment of bosentan was initiated after streptozocin injection and continued for 60 days. RESULTS: Liver from diabetic rats showed significant increase in malondialdehyde (MDA) level and significant decrease in glutathione (GSH), and superoxide dismutase (SOD) activity. Endothelin (ET-1), tumor necrosis factor (TNF-α) and transforming growth factor beta (TGF-ß) gene expression significantly increased in the diabetic groups in the rat liver tissue. Bosentan treatment showed a significant up-regulatory effect on ET-1, TNF-α and TGF-ß mRNA expression. Results from histopathological evaluation of the liver were in accordance with our biochemical and molecular results. CONCLUSIONS: These data provide clear evidence that bosentan treatment is associated with promising hepatoprotective effect against diabetes-induced liver damage via reduction of cell inflammation and oxidative damage. These data suggest that ET receptors may be an important actor in diabetes-related liver damage, and blockage of these receptors may become a target for preventing diabetic complications in the future.


Subject(s)
Chemical and Drug Induced Liver Injury/prevention & control , Diabetes Mellitus, Experimental/complications , Endothelin Receptor Antagonists/pharmacology , Liver/pathology , Sulfonamides/pharmacology , Animals , Bosentan , Chemical and Drug Induced Liver Injury/complications , Diabetes Mellitus, Experimental/chemically induced , Endothelin-1/biosynthesis , Gene Expression Regulation/drug effects , Glutathione/metabolism , Liver/drug effects , Liver/metabolism , Male , Malondialdehyde/metabolism , Rats , Streptozocin , Superoxide Dismutase/metabolism , Transforming Growth Factor beta/biosynthesis , Tumor Necrosis Factor-alpha/biosynthesis
5.
Eur J Obstet Gynecol Reprod Biol ; 170(2): 458-63, 2013 Oct.
Article in English | MEDLINE | ID: mdl-23880599

ABSTRACT

OBJECTIVE: To investigate the role of endothelin receptors in ovarian ischaemia/reperfusion (I/R) injury in rats using the endothelin receptor antagonist bosentan. STUDY DESIGN: Group 1: sham operation; Group 2: sham operation and bosentan 60 mg/kg; Group 3: bilateral ovarian ischaemia; Group 4: 3-h period of ischaemia followed by 3h of reperfusion; Groups 5 and 6: bosentan 30 and 60 mg/kg, respectively, with bilateral ovarian ischaemia applied 30 min later; the bilateral ovaries were removed after 3h of ischaemia; Groups 7 and 8: 3h of bilateral ovarian ischaemia was applied, with bosentan 30 and 60 mg/kg, respectively, administered 2.5h after the induction of ischaemia; following the 3-h period of ischaemia, 3h of reperfusion was applied, after which the ovaries were removed. RESULTS: Ischaemia and I/R decreased superoxide dismutase (SOD) activity and the level of glutathione (GSH) in ovarian tissue, but increased the level of malondialdehyde (MDA) significantly compared with the sham operation group. Bosentan 30 and 60 mg/kg before ischaemia and I/R decreased the MDA level and increased SOD activity and the GSH level in the experimental groups. The serum levels of the inflammatory cytokines interleukin (IL)-1ß, IL-6 and tumour necrosis factor-α were also measured in the I/R injury model in rat ovaries. The levels of these cytokines were significantly higher in the ischaemia and I/R groups compared with the sham operation and sham operation plus bosentan groups. The histopathological findings also demonstrated the protective role of bosentan against I/R-induced injury in rat ovaries. CONCLUSION: Administration of bosentan protects the ovaries against oxidative damage and I/R-induced injury.


Subject(s)
Endothelin Receptor Antagonists , Ovarian Diseases/prevention & control , Reperfusion Injury/prevention & control , Sulfonamides/therapeutic use , Animals , Bosentan , Female , Ovarian Diseases/blood , Ovarian Diseases/etiology , Ovarian Diseases/pathology , Ovary/pathology , Oxidative Stress , Random Allocation , Rats , Rats, Wistar , Receptors, Endothelin/physiology , Reperfusion Injury/blood , Reperfusion Injury/etiology , Reperfusion Injury/pathology , Sulfonamides/pharmacology
6.
Hum Exp Toxicol ; 32(8): 846-57, 2013 Aug.
Article in English | MEDLINE | ID: mdl-23584358

ABSTRACT

Paracetamol was shown to induce hepatotoxicity or more severe fatal acute hepatic damage. Agomelatine, commonly known as melatonin receptor agonist, is a new antidepressant, which resynchronizes circadian rhythms with subjective and objective improvements in sleep quality and architecture, as melatonin does. In the present study, it was aimed to evaluate the hepatoprotective activity of agomelatine on paracetamol-induced hepatotoxicity and to understand the relationship between the hepatoprotective mechanism of agomelatine and antioxidant system and proinflammatory cytokines. A total of 42 rats were divided into 7 groups as each composed of 6 rats: (1) intact, (2) 40 mg/kg agomelatine, (3) 140 mg/kg N-acetylcysteine (NAC), (4) 2 g/kg paracetamol, (5) 2 g/kg paracetamol + 140 mg/kg NAC, (6) 2 g/kg paracetamol + 20 mg/kg agomelatine, and (7) 2 g/kg paracetamol + 40 mg/kg agomelatine groups. Paracetamol-induced hepatotoxicity was applied and liver and blood samples were analyzed histopathologically and biochemically. There were statistically significant increases in the activities of aspartate aminotransferase, alanine aminotransferase, levels of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) and 8-iso-prostane, and decreases in the activity of superoxide dismutase and level of glutathione in the group treated with paracetamol. Administration of agomelatine and NAC separately reversed these changes significantly. In conclusion, agomelatine administration protects liver cells from paracetamol-induced hepatotoxicity via antioxidant activity and reduced proinflammatory cytokines, such as TNF-α and IL-6.


Subject(s)
Acetamides/therapeutic use , Antidepressive Agents/therapeutic use , Chemical and Drug Induced Liver Injury/drug therapy , Protective Agents/therapeutic use , Acetamides/pharmacology , Acetaminophen , Alanine Transaminase/blood , Animals , Antidepressive Agents/pharmacology , Aspartate Aminotransferases/blood , Chemical and Drug Induced Liver Injury/metabolism , Chemical and Drug Induced Liver Injury/pathology , Dinoprost/analogs & derivatives , Dinoprost/metabolism , Glutathione/metabolism , Interleukin-6/blood , Liver/drug effects , Liver/metabolism , Liver/pathology , Male , Protective Agents/pharmacology , Rats , Rats, Wistar , Superoxide Dismutase/metabolism , Tumor Necrosis Factor-alpha/blood
7.
Cell Mol Biol (Noisy-le-grand) ; 59 Suppl: OL1835-41, 2013 Feb 02.
Article in English | MEDLINE | ID: mdl-23374453

ABSTRACT

This study evaluated the protective effect of Panax Ginseng (PG) on bone metabolism in an experimental ovariectomy (OVX) model of osteoporosis in which inflammation was induced by subcutaneous magnesium silicate. The groups were: sham control (Group1, SH), sham+inflammation (Group2, SHinf), OVX (Group3), OVX+inflammation (Group4, OVXinf), OVX+inflammation+PG 100 mg/kg (Group5, OVXinf+PG1), OVX+inflammation+PG 200 mg/kg (Group6, OVXinf+PG2), OVX+PG 100 mg/kg (Group7, OVX+PG1), OVX+PG 200 mg/kg (Group8, OVX+PG1). After the OVX surgery, all the groups were allowed to recover for two months. On the 59th day after the OVX, inflammation was induced in Groups 2, 4, 5, and 6 by subcutaneous injections of magnesium silicate in the back of the animals. Groups 5 and 7 were administered oral PG 100 mg/kg, and Groups 6 and 8 were administered oral PG 200 mg/kg from the 60th to the 80th day. PG 200 mg/kg was able to restore BMD, up to values measured in both the OVX and the SH animals. The levels of OC and OP decreased in OVXinf+PG1 and OVXinf+PG2 groups. The serum levels of TNF­α, IL­1ß, and IL­6 were increased significantly in the OVXinf rats compared with the SH group. The present data showed that PG protected against in the OVX model and in inflammation-induced bone loss rat model.


Subject(s)
Bone Density/drug effects , Osteoporosis/prevention & control , Panax/chemistry , Plant Extracts/therapeutic use , Animals , Bone and Bones/metabolism , Bone and Bones/pathology , Inflammation/chemically induced , Inflammation/complications , Magnesium Silicates , Male , Osteoporosis/etiology , Osteoporosis/metabolism , Oxidative Stress , Phytotherapy , Rats , Rats, Wistar
8.
Cell Mol Biol (Noisy-le-grand) ; 58 Suppl: OL1680-7, 2012 Jun 15.
Article in English | MEDLINE | ID: mdl-22762529

ABSTRACT

We investigated the potential protective effects of Nigella sativa (NS) on mortality, serum levels of proinflammatory cytokines, oxidative stress and histopathological changes in lung tissues, in cecal ligation and puncture (CLP)-induced sepsis model in rats. Sepsis induction by CLP, determination of serum cytokine levels by ELISA, spectrophotometric determination of oxidative stress parameters, and histological examination of lung tissues. The rat groups were: 1) CLP group, 2) sham group, 3) NS500-sham group, 4) NS125, 5) NS250, 6) NS500 groups. NS treatment significantly decreased proinflammatory cytokine levels in serum; LPO level, MPO activity, and pathological changes in lung tissues, in CLP-induced sepsis, while significantly increasing GSH levels and SOD activity in the lung tissue. NS treatment after CLP potentially reduced mortality and may exert effects through the reduction in tissue oxidative stress and serum cytokines. The histopathological changes were minimized in lung tissue by NS, under sepsis conditions. We can suggest that NS reverses the systemic inflammatory reaction to polymicrobial sepsis and thereby reduces multiple organ failure. It may be suggested that role of the NS ethanolic extract in preventing formation of CLP induced sepsis, is due to the anti-inflammatory and antioxidant effects of the different compounds of the black seeds.


Subject(s)
Lung Injury/drug therapy , Nigella sativa/chemistry , Plant Extracts/therapeutic use , Sepsis/complications , Animals , Cecum , Cytokines/blood , Disease Models, Animal , Glutathione/metabolism , Ligation , Lipid Peroxidation/drug effects , Lung Injury/etiology , Lung Injury/metabolism , Lung Injury/pathology , Male , Peroxidase/metabolism , Plant Extracts/pharmacology , Punctures , Rats , Rats, Wistar , Superoxide Dismutase/metabolism
9.
Arch Pharm Res ; 30(11): 1426-34, 2007 Nov.
Article in English | MEDLINE | ID: mdl-18087811

ABSTRACT

Reactive oxygen species (ROS) have been implicated in the etiology of indomethacin-induced gastric mucosal damage. This study investigated amiodarone's protective effects against oxidative gastric mucosal damage induced by indomethacin. Amiodarone is a widely used antiarrhythmic agent. We have investigated alterations in the glutathione level, and the activities of antioxidative enzymes [superoxide dismutase, catalase, glutathione s-transferase glutathione reductase and myeloperoxidase], as markers for ulceration process following oral administration of amiodarone and ranitidine in rats with indomethacin-induced ulcers. In the present study we found that 1) amiodarone, lansoprazole and ranitidine reduced the development of indomethacin-induced gastric damages, at a greater magnitude for amiodarone and lansoprazole than for ranitidine; 2) amiodarone and ranitidine alleviated increases in the activities of catalase and glutathione s-transferase enzymes resulting from ulcers; 3) amiodarone and ranitidine ameliorated depressions in the glutathione level and the activities of superoxide dismutase and glutathione reductase enzymes caused by indomethacin administration; and 4) all doses of amiodarone amplified the myeloperoxidase activity resulting from indomethacin-induced gastric ulcers. The results indicate that the gastroprotective activity of amiodarone, which may be linked to its intrinsic antioxidant properties, cannot be attributed to its effect on myeloperoxidase activity.


Subject(s)
Amiodarone/pharmacology , Antioxidants/pharmacology , Gastric Mucosa/drug effects , Indomethacin/pharmacology , Stomach Ulcer/prevention & control , Animals , Glutathione/metabolism , Glutathione Transferase/metabolism , Male , Neutrophil Infiltration/drug effects , Peroxidase/metabolism , Ranitidine/pharmacology , Rats , Rats, Sprague-Dawley , Reactive Oxygen Species/metabolism , Stomach Ulcer/chemically induced
10.
Phytomedicine ; 13(8): 584-90, 2006 Sep.
Article in English | MEDLINE | ID: mdl-16920514

ABSTRACT

The antiulcerogenic effect of diffractaic acid (DA) isolated from Usnea longissima, a lichen species, on indomethacin (IND)-induced gastric lesions was investigated in rats. Administration of 25, 50, 100 and 200 mg/kg doses of DA and ranitidine (RAN) (50 mg/kg dose) reduced the gastric lesions by 43.5%, 52.9%, 91.4%, 96.7% and 72.7%, respectively. It is known that oxidative stress leads to tissue injury in organisms. Thus, in all treated groups of rats, the in vivo activities of the antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and the levels of reduced glutathione (GSH) and lipid peroxidation (LPO) were evaluated. IND caused oxidative stress, which resulted in LPO in tissues, by decreasing the levels of GPx, SOD and GSH as compared to healthy rats. In contrast to IND, the administration of DA and RAN showed a significant decrease in LPO level and an increase in tissue SOD, GPx and GSH levels. However, while CAT activity was significantly increased by the administration of IND, the administration of DA and RAN decreased CAT activity. The administration of IND also increased the myeloperoxidase (MPx) activity, which shows neutrophil infiltration into the gastric mucosal tissues. In contrast to IND, the administration of DA and RAN decreased MPx activity. The changes in activities of gastric mucosal nitric oxide synthases (NOS) throughout the development of gastric mucosal damage induced by IND were also studied. A decrease in constitutive NOS (cNOS) activity and an increase in inducible NOS (iNOS) activity were determined in gastric damaged tissues induced by IND. The administration of DA (100 mg/kg dose) and RAN reversed the activities of iNOS and cNOS. These results suggest that the gastroprotective effect of DA can be attributed to its enhancing effects on antioxidant defense systems as well as reducing effects of neutrophil infiltration.


Subject(s)
Anisoles/pharmacology , Hydroxybenzoates/pharmacology , Neutrophil Infiltration/drug effects , Oxidative Stress/drug effects , Stomach Ulcer/drug therapy , Usnea/chemistry , Animals , Anisoles/isolation & purification , Anisoles/therapeutic use , Antioxidants/metabolism , Gastric Mucosa/drug effects , Gastric Mucosa/enzymology , Glutathione/drug effects , Hydroxybenzoates/isolation & purification , Hydroxybenzoates/therapeutic use , Indomethacin , Lipid Peroxidation/drug effects , Male , Oxidation-Reduction , Rats , Rats, Wistar , Stomach Ulcer/enzymology
11.
Phytomedicine ; 12(9): 656-62, 2005 Sep.
Article in English | MEDLINE | ID: mdl-16194053

ABSTRACT

In this study, the antiulcerogenic effect of a water extract obtained from the lichen species Usnea longissima was investigated using indomethacin-induced ulcer models in rats. Experimental groups consisted of six rats. Antiulcerogenic activities of 50, 100 and 200mg/kg body wt. doses of the water extract were determined by comparing the negative (treated only with indomethacin) and positive (ranitidine) control groups. Although all doses of the water extract of U. longissima showed significant antiulcerogenic activity as compared to negative control groups, the highest activity was observed with 100 mg/kg body wt. doses (79.8%). The water extract of U. longissima showed moderate antioxidant activity when compared with trolox and ascorbic acids used as positive antioxidants. In addition, the activities of antioxidant enzymes [superoxide dismutase (SOD), catalase (CAT) and glutathione S-transferase (GST)] were determined in the stomach tissues of rats and compared with those of the negative and positive control groups to expose the effects of antioxidant enzymes on antiulcerogenic activity. SOD and GST enzymes activities in indomethacin-administrated tissues were reduced significantly by indomethacin in comparison to control groups. These enzymes were activated, however, by the water extracts of U. longissima. In contrast to SOD and GST activities, CAT activity was increased by indomethacin and reduced by all doses of U. longissima and ranitidine. The present results indicate that the water extract of U. longissima has a protective effect in indomethacin-induced ulcers, which can be attributed to its antioxidant potential.


Subject(s)
Anti-Ulcer Agents/pharmacology , Antioxidants/pharmacology , Phytotherapy , Plant Extracts/pharmacology , Stomach Ulcer/prevention & control , Stomach/drug effects , Usnea , Animals , Anti-Ulcer Agents/administration & dosage , Anti-Ulcer Agents/therapeutic use , Antioxidants/administration & dosage , Antioxidants/therapeutic use , Catalase/metabolism , Dose-Response Relationship, Drug , Glutathione Transferase/metabolism , Indomethacin , Male , Plant Extracts/administration & dosage , Plant Extracts/therapeutic use , Rats , Rats, Wistar , Stomach/enzymology , Stomach Ulcer/chemically induced , Superoxide Dismutase/metabolism
12.
Fitoterapia ; 76(2): 216-9, 2005 Mar.
Article in English | MEDLINE | ID: mdl-15752633

ABSTRACT

The total antioxidant activity, total phenolic content and reducing power of methanol and water extracts of four lichen species, Bryoria fuscescens, Dermatocarpon intestiniformis, Peltigera rufescens and Pseudevernia furfuracea, were determined in vitro. Water and methanol extracts of P. rufescens showed the highest antioxidant activity. However, there was no correlation between antioxidant activity and total phenolic content of the extracts. Although the methanol extract of P. furfuracea had the highest total phenolic contents, it exhibited low antioxidant activity. In contrast, there was a strong correlation between reducing power and total antioxidant activity of the extracts. The highest reducing power was determined for the methanol extract of P. rufescens.


Subject(s)
Antioxidants/pharmacology , Lichens , Phytotherapy , Plant Extracts/pharmacology , Antioxidants/chemistry , Humans , Phenols/chemistry , Plant Extracts/chemistry
13.
Phytomedicine ; 10(6-7): 552-7, 2003.
Article in English | MEDLINE | ID: mdl-13678242

ABSTRACT

An aqeuous extract of Lobaria pulmonaria (L.) Hoffm., from which a tea is prepared and consumed as treatment for various diseases in northeastern Turkey, was tested for its anti-inflammatory and antiulcerogenic effects in rats. The carrageenan-induced paw edema, cotton pellet granuloma and indomethacin-induced gastric damage models were used to determine these effects. The extract exhibited moderate anti-inflammatory and strong antiulcerogenic activities.


Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Anti-Ulcer Agents/pharmacology , Edema/prevention & control , Granuloma, Foreign-Body/prevention & control , Lichens , Phytotherapy , Plant Extracts/pharmacology , Stomach Ulcer/prevention & control , Animals , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Anti-Ulcer Agents/administration & dosage , Anti-Ulcer Agents/therapeutic use , Beverages , Carrageenan , Edema/chemically induced , Indomethacin , Male , Medicine, Traditional , Plant Extracts/administration & dosage , Plant Extracts/therapeutic use , Rats , Rats, Wistar , Stomach Ulcer/chemically induced , Tea , Turkey
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