Tribute to Dianne Rekow-Dental "Imagineer".

Elizabeth Dianne Rekow, BSME, MSME, MBA, DDS, MS, Certificate in Orthodontics, and PhD (1944-2022), was a dental science futurist pursuing brave new paths during her career. She was one of the pivotal scientists who initiated the CAD/CAM movement in the 1980s and went on to focus on digital dentistry for the rest of her career. Her professional contributions involved seven patents, 92 peer-reviewed publications, 10 book contributions, 31 proceeding contributions, and well over 100 national and international presentations. She was an avid supporter of women in science. Her greatest contribution was her expansive imagination. She served as 35th president of the American Association for Dental, Oral, and Craniofacial Research in 2006-2007 and 88th president of the International Association for Dental Research in 2011-2012. The present article reviews key elements of her career and includes testimonies from friends about her special relationships.

The Evolution of Dental Materials over the Past Century: Silver and Gold to Tooth Color and Beyond.

The field of dental materials has undergone more of a revolution than an evolution over the past 100 y. The development of new products, especially in the past half century, has occurred at a staggering pace, and their introduction to the market has been equally impressive. The movement has mostly come in the area of improved esthetics, marked by the gradual replacement of dental amalgam with dental composite and all-metal and porcelain-fused-to-metal indirect restorations with reinforced dental ceramics, all made possible by the rapid improvements in dental adhesive materials. This article covers the time course of dental materials development over the past century in which the Journal of Dental Research has been published. While there have been advances in nearly all materials used in the field, this article focuses on several areas, including dental amalgam, dental composites and light curing, dental adhesives and dental cements, ceramics, and new functional repair materials. A few short statements on future advances will be included at the end.

Clinical studies in restorative dentistry: New directions and new demands.

Clinical research of restorative materials is confounded by problems of study designs, length of trials, type of information collected, and costs for trials, despite increasing numbers and considerable development of trials during the past 50 years. This opinion paper aims to discuss advantages and disadvantages of different study designs and outcomes for evaluating survival of dental restorations and to make recommendations for future study designs. Advantages and disadvantages of randomized trials, prospective and retrospective longitudinal studies, practice-based, pragmatic and cohort studies are addressed and discussed. The recommendations of the paper are that clinical trials should have rational control groups, include confounders such as patient risk factors in the data and analysis and should use outcome parameters relevant for profession and patients.

What constitutes an ideal dental restorative material?

Intense environmental concerns recently have prompted dentistry to evaluate the performance and environmental impact of existing restoration materials. Doing so entices us to explore the 'what if?' innovation in materials science to create more ideal restorative materials. Articulating a specification for our design and evaluation methods is proving to be more complicated than originally anticipated. Challenges exist not only in specifying how the material should be manipulated and perform clinically but also in understanding and incorporating implications of the skill of the operator placing the restoration, economic considerations, expectations patients have for their investment, cost-effectiveness, influences of the health care system on how and for whom restorations are to be placed, and global challenges that limit the types of materials available in different areas of the world. The quandary is to find ways to actively engage multiple stakeholders to agree on priorities and future actions to focus future directions on the creation of more ideal restorative materials that can be available throughout the world.

Dental restorations for oral rehabilitation - testing of laboratory properties versus clinical performance for clinical decision making.

At the outset, the categories of physical, chemical, mechanical, biological and clinical properties of biomaterials are reviewed in terms of their definitions and relevant examples. Clinical performance for restorative materials is considered in terms of five crucial categories of factors (operator, design, materials, site and patient). Clinical performance assessment in actual clinical trials is described in terms of United States Public Health Service (USPHS) and modified USPHS categories of ratings collected from direct observations. Clinical failure analysis is characterized using reverse s-shaped curves to summarize longevity (failure or success) and clinical longevity for 50% failures (CL(50)) is defined. Actual practice effectiveness is demonstrated as being approximately one-half of clinical trial efficacy. Types of restorative dental material clinical trials are contrasted (longitudinal versus cross-sectional, short-term versus long-term, university-based versus practice-based research networks). Poor correlations between laboratory test values and clinical performance are explained. The need for risk assessment is emphasized. Evidence-based dentistry is defined in terms of available published information and precautions. At this point, the evidence base for clinical performance of biomaterials is scant.

Clinical evaluation of two one-bottle dentin adhesives at three years.

BACKGROUND: The method currently used to adhere resin to dentin involves etching, priming and bonding. Many commercial adhesives now combine priming and bonding functions in a single solution, and these are frequently called one-bottle adhesives. The purpose of this study was to compare the 36-month clinical performance of two commercial one-bottle adhesives. METHODS: The authors enrolled 33 patients with noncarious cervical lesions in the study. A total of 101 lesions were restored with either a filled, ethanol-based adhesive (OptiBond Solo, SDS Kerr) or an unfilled, acetone-based adhesive (Prime & Bond 2.1, Dentsply Caulk) and a hybrid resin-based composite. Enamel margins were not beveled, and no mechanical retention was placed. The restorations were evaluated at baseline and six months, 18 months and 36 months after placement using modified Cvar/Ryge criteria. RESULTS: The retention rates at 36 months were 93.3 percent for the ethanol-based adhesive and 89.4 percent for the acetone-based adhesive. The difference in retention rates was not statistically significant. In both groups, 12 percent of the retained restorations had marginal staining, but no recurrent caries was detected around any restoration. Other restoration characteristics such as marginal adaptation and color match remained excellent three years after placement. CONCLUSIONS: The performance of both adhesives was excellent during this 36-month clinical trial. At the most recent recall evaluation (that is, 36 months), the filled, ethanol-based adhesive exhibited slightly better bond durability, but the difference between the two materials was not statistically significant. CLINICAL IMPLICATIONS: The one-bottle adhesives evaluated in this study provided excellent clinical retention of Class V restorations without mechanical retention. When the materials are used properly, restorations are retained at a high rate during at least three years of clinical service.

Eighteen-month clinical evaluation of a filled and unfilled dentin adhesive.

OBJECTIVE: The purpose of this study was to evaluate the performance of a filled (OptiBond Solo) and an unfilled (Prime & Bond 2.1) "one-bottle" adhesive in Class V restorations after 18 months of clinical service. METHODS: Thirty-three patients with non-carious cervical lesions were enrolled in the study. A total of 101 lesions were restored using one of the adhesives and a hybrid composite resin. Enamel was not beveled, nor was any mechanical retention placed. The restorations were evaluated at baseline, and at 6 and 18 months after placement using modified USPHS criteria. RESULTS: Cumulative 18-month retention rates were 93.6% for OptiBond Solo and 98.0% for Prime & Bond 2.1. The difference in retention rates was not statistically significant. For OptiBond Solo, the only notable problems were interfacial staining and marginal adaptation, both of which were less than ideal in 9% of restorations. Marginal problems were slightly less frequent for Prime & Bond 2.1 restorations, but the difference was not significant. CONCLUSIONS: Both adhesives provided Class V retention rates exceeding the 18-month, full acceptance guidelines set by the American Dental Association. Any additional benefit provided by the use of a filled adhesive was not detected in this 18-month clinical trial.

Predictions of cement microfracture under crowns using 3D-FEA.

PURPOSE: The objective of this research study was to test the effects of (1) crown margin type, (2) cement type, (3) cement thickness, (4) loading direction, and (5) loading magnitude on stress levels and distributions within luting cement that might lead to cement microfracture using three-dimensional Finite Element Analysis techniques. MATERIALS AND METHODS: Thirty-two three-dimensional computer models, as well as models for standards, were generated for a mandibular first premolar. Crown preparations exhibited shoulder or chamfer margin configurations, and zinc phosphate, zinc polycarboxylate, glass ionomer, and resin cements were used in thicknesses of 25 or 100 microm. Modeled crowns were loaded axially or obliquely at 10 and 100 MPa. Areas and levels of stress concentrations within the cement were determined. RESULTS: Stresses in the cement were low for all situations except 100 MPa oblique stressing. Stresses at the margins of crowns with chamfer marginal configuration were higher than those with shoulder margins. Stresses under oblique stressing were 10 to 150 times higher than under axial stressing. Except for Zn phosphate cement, cement thickness minimally affected stress levels and distributions. Greater stresses were found in cements with the greater Young's modulus. CONCLUSIONS: Although the chamfer margin design could lead to greater stresses near the margins that places the cement at risk for microfracture and possible crown failure, glass-ionomer and composite resin cements have more favorable mechanical properties for resisting microfracture.

Our future in restorative dental materials.

Restorative dentistry is moving toward more extensive diagnosis, caries risk assessment, and non-invasive caries management. There will be less restorative intervention and more conservation of existing tooth structure whenever possible. Prevention, minimal intervention, and restoration maintenance will be key guidelines. Restorative materials will continue to evolve slowly and steadily (Figure 1). However, most of the guiding principles for cavity preparation and restoration will be the same as they have been for the past decade. During the coming decade, practitioners will see the first evidence of tooth replacement with genetically equivalent teeth.

Two-year clinical evaluation of tooth whitening using an at-home bleaching system.

PURPOSE: The purpose of this study was to evaluate the 2-year effectiveness of a carbamide peroxide at-home bleaching gel used to provide tooth lightening treatment. MATERIAL AND METHODS: Twenty-nine patients participated in the original study, during which they treated their maxillary teeth with a 10% carbamide peroxide gel nightly for 2 weeks. Shades were determined before and after treatment by comparison with a Vita shade guide. Twenty-four patients (a recall rate of 83%) were recalled for evaluation 2 years after the initial bleaching treatment. The shade of the maxillary incisors was evaluated and compared with shades before, immediately after, and at 6 months and 2 years after initial treatment. Data were analyzed using a repeated-measures analysis of variance. RESULTS: At 2 years after bleaching with a 10% carbamide peroxide gel, the median shade was D2, a six-increment difference from the baseline median of D3. Twenty of 24 patients (83.3%) had a shade change of two or more units, which is the threshold value for bleaching efficacy using American Dental Association guidelines. The lightening result remained statistically significant (p < .0001) at 2 years. CLINICAL SIGNIFICANCE: Although some reversal of the lightening effect occurs over time following the original bleaching treatment, loss of the lighter color appears to be gradual for most patients. Although the longevity of the lightening effect remains to be determined, this clinical trial indicates that the majority of patients have a satisfactory result 2 years after treatment.

Seventeen-year clinical study of ultraviolet-cured posterior composite Class I and II restorations.

OBJECTIVES: To compare the clinical performance of four commercial ultraviolet light-cured composite materials, and to evaluate curing-system effects on long-term wear resistance of Class I and II restorations. MATERIALS AND METHODS: Approximately 32 samples of each of four different ultraviolet light-cured composites (n = 130) were inserted into conventional Class I and II cavity preparations by two clinicians. Cavosurface margins of the preparations were not beveled. Enamel walls of the preparation were etched, and the respective bonding agent was applied. Each restoration was evaluated by two clinicians at 5, 10, and 17 years. Direct evaluations were performed using modified United States Public Health Service (USPHS) criteria. Indirect evaluations were performed using the Leinfelder cast evaluation method. RESULTS: After 17 years, 65% of the restorations were recalled and pooled direct evaluations were conducted for color matching (94% alfa), marginal discoloration (100% alfa), marginal integrity (100% alfa), secondary caries (92% alfa), surface texture (72% alfa), and anatomic form (22% alfa). Mean occlusal wear from indirect evaluations at 5, 10, and 17 years was 197 +/- 85 microns, 235 +/- 72 microns, and 264 +/- 80 microns, respectively. For direct and indirect evaluations there were significant differences (p < or = .05) between the baseline and 5-year recall evaluations. CLINICAL SIGNIFICANCE: This study demonstrated that the mean pooled occlusal wear of four ultraviolet light-cured posterior composites at 17 years was 264 microns (approximately 0.25 mm), and that most wear (75%) occurred in the first 5 years. Of all recalled restorations, 76% were judged clinically acceptable at 17 years, and 22% of those exhibited no clinically detectable wear.

Margin gap size of ceramic inlays using second-generation CAD/CAM equipment.

OBJECTIVE: The goal of this study was to determine if the fit of second-generation computer-assisted design/computer-assisted manufacturing (CAD/CAM) (CEREC 2, Sirona Dental Systems, Bensheim, Germany) inlays within Class II cavity preparations were within the range of 50 to 100 microns and were equal or better to CEREC 1 inlays. MATERIALS AND METHODS: Extracted human molars free of surface defects and caries were prepared with standard mesio-occlusodistal cavity preparations. Ceramic inlays were fabricated with CEREC 2 CAD/CAM equipment and seated into cavity preparations. Digital images were captured at 100 times magnification. Marginal gaps were measured with an image analysis program. For each restoration, gaps were measured at 12 locations along interproximal margins and 10 locations along occlusal margins. RESULTS: No difficulty occurred in seating any of the milled inlays. Average marginal gaps for occlusal (59 +/- 35 microns) and interproximal (97 +/- 66 microns) margins were statistically different (t-test, p < or = .01). Average marginal gap for all sites combined was 80 +/- 57 microns. Marginal gap widths were smaller than those obtained from a similar study done earlier with the CEREC 1 unit for occlusal (89 +/- 65 microns) and interproximal (105 +/- 81 microns) margins. Ease of seating with CEREC 2 inlays was much better than with CEREC 1. CLINICAL SIGNIFICANCE: Improvements in software and hardware allow the CEREC 2 to adapt well to standard inlay cavity preparations. The ability of the device to create inlays that seat without interference is remarkable. The improved fit and ability to create the occlusal surface in a variety of ways make CEREC 2 an attractive restorative option for all-ceramic restorations.

Packable composites: overview and technical considerations.

OBJECTIVE: New composites, called packable or condensable composites, are being promoted as amalgam alternatives. The purposes of this review article are to identify these products, define new terminology associated with them, summarize the advertised properties for the materials, discuss the ideal properties for packable composites, review the properties of the major products, and critically evaluate the proposed handling procedures for these materials. REVIEW: The term packable is preferable to condensable for describing this new class of materials. All materials should be considered amalgam alternatives, not amalgam substitutes. The compositions and physical properties reported by manufacturers reveal that none of the materials represents a remarkable improvement over the properties of more traditional universal composites. The designs of Solitaire (Heraeus Kulzer), ALERT (Jeneric-Pentron), and SureFil (Dentsply/Caulk) are discussed in detail. The distinguishing characteristics of all packable compositions are less stickiness or stiffer viscosity than conventional composites, which allow them to be placed in a manner that somewhat resembles amalgam placement. CONCLUSIONS: Packable composites may allow more convenient placement in posterior sites and may offer some technique advantages over conventional composites. However, there is no evidence that their clinical properties are consistently better than those of conventional universal composites. CLINICAL SIGNIFICANCE: Packable composites may be selected as alternatives to amalgam or conventional universal composites, but they are not equal to or better than dental amalgam in all respects. Also, in most cases, mechanical properties of packable composites are not substantially better than those of most conventional universal composites.

Clinical evaluation of two carbamide peroxide tooth-whitening agents.

A blinded study was conducted to evaluate the efficacy and safety of a dentist-prescribed, accelerated carbamide peroxide tooth-whitening system. Fifty-one patients with discolored teeth completed a clinical trial using an overnight bleaching regimen. One group used an experimental bleaching (whitening) regimen with 10% carbamide peroxide bleaching paste, and another group used the Colgate Platinum Professional Overnight Whitening System. The study included an initial 1-week control/compliance phase using a placebo gel, followed by a 1-week active phase using the assigned bleaching agent. The shade of each participant's maxillary anterior teeth was evaluated by 2 trained and calibrated evaluators at the start of the control/compliance phase, the beginning of the active phase, and days 3, 5, and 7 of the active phase. A value-oriented Vita shade guide with 16 rankings was used to measure color changes, and the number of shade guide units of change (delta sgu) was calculated. Potential side effects, such as tooth hypersensitivity and gingival irritation, also were assessed at each recall examination, as well as recorded by the patients in their daily diaries. At the end of the 7-day active phase, the mean delta sgu for the group using the experimental bleaching agent was 7.1 +/- 2.4, and for the Colgate Platinum Overnight group, the delta sgu was 7.5 +/- 2.2. There were no statistically significant (p > or = 0.05) differences between the results of both groups at the 0-, 3-, 5-, and 7-day evaluations. After 7 days, the change in shade guide units for both groups ranged from 3 to 13 units, far exceeding the minimum required change by the American Dental Association Guidelines (delta sgu = 2 units) for demonstrating efficacy. There was no statistical difference in the whitening achieved at day 5 vs. day 7 for either tooth-whitening group. There were no notable changes in any gingival, bleeding, or plaque indexes for the 50 patients completing the active phase. The number of days of mild tooth sensitivity during the active phase was 0.9 +/- 1.3 days for the experimental agent group and 1.1 +/- 1.5 days for the Colgate Platinum group.

Effect of powder/liquid ratio on the clinical and laboratory performance of resin-modified glass-ionomers.

OBJECTIVES: To compare the effects of powder/liquid (P/L) ratio and surface wetness on retention of adhesive Class V restorations. METHODS: One-hundred and six Fuji II LC restorations were placed at two clinical trial sites. In the 'high-dry group (Site A), Fuji II LC was mixed at a P/L ratio of 3.0 and applied to dentine that was visibly dry, but not desiccated. In the 'low-wet' group (Site B), Fuji II LC was mixed at a P/L ratio of 2.25 and applied to dentine that was glisteningly moist. The restorations were evaluated at baseline, 1 and 2 years at both sites, and at 3 years at one site. The P/L ratio effects on viscosity and wetting were evaluated in vitro by determining the film thickness possible at different ratios. RESULTS: At 2 years the retention levels at the two sites differed significantly (p < or = 0.1). Site B ('low-wet' group) exhibited 100% retention, and Site A ('high-dry' group) exhibited 78% retention. At 3 years Site A exhibited 74% retention, and nine of the 12 retention failures occurred in patients 65 years and older. Laboratory measurements demonstrated that the viscosity of 'low-wet' mixtures permitted film thickness that were one-half those of the 'high-dry' group. CONCLUSIONS: The study demonstrated that a higher powder/liquid ratio and a drier dentine surface compromised wetting by a resin-modified glass-ionomer resulting in a decline in retention from baseline to 3 years. This study suggests that the dentine surface should be kept hydrated to promote bonding, and that the powder/liquid ratio should be low enough to create low-viscosity mixtures which promote wetting. In the 'high-dry' dentine group there was still 74% retention at 3 years, indicating that factors other than wetting affect retention.