Cystic fibrosis in Canadian Hutterites.

BACKGROUND: The Hutterite Brethren are a communal group of Anabaptists who live in the Western regions of North America, predominantly in the Western Canadian provinces. Due to a founder effect, Hutterites have a high rate of cystic fibrosis (CF) with genotypes limited to only two CFTR mutations. One-third of Hutterite patients with CF are pancreatic sufficient. Previously we found an unexplained younger age at death in Hutterites compared with nonHutterites homozygous for the common F508del mutation. The present study expanded the data collection and analysis for confirmation and further exploration. METHODS: Anonymized information, based on Hutterite surnames, was extracted from the Canadian CF Registry. Summary data on nonHutterite patients with CF homozygous for F508del served as control. Statistical analyses explored the effects of genotype within Hutterites and compared nutritional status, lung function, and microbiologic findings between the groups. RESULTS: The younger average age at death in Hutterites compared with controls was confirmed, but there was no suggestion of a generally shortened life expectancy. While the nutritional status in Hutterite children was better than that of controls, their lung function was slightly but significantly lower. Staphylococcus aureus was more frequent in Hutterites while there was no difference between the groups regarding Pseudomonas aeruginosa. CONCLUSIONS: Despite less pancreatic insufficiency, better nutrition, communal life in socioeconomic stability, and without exposure to environmental tobacco smoke, the clinical course of CF appears to be more severe in a significant number of Hutterites. Investigations of gene-environment interactions and of CF disease gene modifiers may help to explain this conundrum.

Nutritional risk in community-dwelling older men: the Manitoba follow-up study.

PURPOSE: The role of nutrition in older men's health and successful aging has been inadequately studied. We examined the relationships among nutritional risk, self-rated health, and successful aging in community-dwelling Canadian older men. METHODS: The surviving cohort of the Manitoba Follow-up Study (n=690, mean age = 86.8 years) were sent a self-administered nutrition survey in December 2007. The survey consisted of the Seniors in the Community: Risk Evaluation for Eating and Nutrition, version II (SCREEN II), a validated tool for assessing nutritional risk of cognitively intact community-living older adults, and questions about successful aging and health. RESULTS: Of the 553 surveys returned (80% response), 522 with complete SCREEN II data were included in the analysis. Forty-four percent of respondents were at high nutritional risk, 24% were at moderate risk, and 32% were at low risk. Significant relationships were found between nutritional risk and self-rated health (P<0.0001) and successful aging (P=0.008), with greater nutritional risk associated with lower self-ratings of health and successful aging. Higher use of prescription medication was related to greater nutritional risk (P=0.004). CONCLUSIONS: Nutritional screening programs for community-dwelling older men are warranted as two-thirds of the study participants were at nutritional risk. Identifying older men at nutritional risk is a critical step in the process of nutritional assessment, and subsequent nutrition interventions and follow-up are required to prevent further health decline.

Older men's lay definitions of successful aging over time: the Manitoba follow-up study.

The concept of "successful aging" has become widely accepted in gerontology, yet continues to have no common underlying definition. Researchers have increasingly looked to older individuals for their lay definitions of successful aging. The present analysis is based on responses to five questionnaires administered to surviving participants of the male Manitoba Follow-up Study cohort (www.mfus.ca) in 1996, 2000, 2002, 2004, and 2006 (n = 2,043 men were alive at a mean age of 78 years in 1996). One question on each survey asked: "What is YOUR definition of successful aging?" Applying content analysis to the 5,898 narratives received over the 11 years, we developed a coding system encompassing 21 main themes and 86 sub-themes defining successful aging. We quantitatively analyzed trends in prevalence of themes of successful aging prospectively over time. Our findings empirically support colleagues' past suggestions to shift from defining successful aging in primarily biomedical terms, by taking lay views into account.

Clinical diagnoses before age 75 and men's survival to their 85th birthday: the Manitoba follow-up study.

PURPOSE: Of all Canadian and American men who live to age 75 years, about half can expect to live to age 85. Our objective is to examine how clinical diagnoses made before age 75 relate to a man's survival to age 85 years. DESIGN AND METHODS: Since 1948, a cohort of 3,983 young men (mean age of 31 years at entry) has been followed with routine contact and medical examinations to prospectively document incident disease. Over 62 years of follow-up, 2,414 of the cohort lived to celebrate their 75th birthday. Of these survivors, 1,060 (44%) died before their 85th birthday. Cox proportional hazard models were used to examine the effects of ischemic heart disease, cancer, cerebrovascular disease, diabetes mellitus, peripheral arterial disease, and chronic obstructive pulmonary disease on all-cause mortality between age 75 and 85 years. RESULTS: Modeled as six binary risk factors at age 75 years, all were significantly (p < .01) and independently related to 10-year mortality. Multivariate risk ratios ranged from 1.36 to 1.46 except for chronic obstructive pulmonary disease with a risk ratio of 1.85 (95% CI: 1.38, 2.49). The cumulative 10-year probability of survival from age 75 to 85 among men with none of these diagnoses was 63%, 52% for any one diagnosis, 39% for two diagnoses, and 22% for three or more diagnoses. IMPLICATIONS: Joint independence of these six common clinical diagnoses implies that each is important and their effects on mortality are cumulative.

The consistency of definitions of successful aging provided by older men: the Manitoba follow-up study.

ABSTRACTIn the absence of a universally agreed-upon definition of successful aging, researchers increasingly look to older adults for layperson views of aging and definitions of successful aging. To use lay definitions in studies of aging, however, researchers must address the definitions' consistency. In 2004, surviving members of the Manitoba Follow-up Study male cohort (mean age: 83 years) were asked twice for their definition of successful aging. A consistency category was assigned based on the similarity of themes in each of 654 pairs of definitions. At least half of the main themes were similar in 70 per cent of the definition pairs; 80 per cent of respondents repeated at least one theme. Positive or negative health events in the four-week interval between definitions and specific respondents' characteristics did not vary across consistency categories. This evidence for consistency supports our continued reliance on lay definitions of successful aging.

Ability and accuracy of long-term weight recall by elderly males: the Manitoba follow-up study.

PURPOSE: To assess the ability and accuracy of elderly men to recall their weights and determine what characteristics might predict recall ability and accuracy. METHODS: Eight hundred sixty-nine elderly men (mean age, 84 years), participants of the Manitoba Follow-up Study (MFUS), responded to a questionnaire asking them to recall their weights at ages 20, 30, 50, and 65 years. Recalled weights were compared with measured weights collected since MFUS began in 1948. Logistic regression was used to predict ability and accuracy of weight recall. RESULTS: Only 75% of respondents attempted to recall their weights at all 4 ages. Among men recalling 4 weights, fewer than half were accurate within +/- 10%, just 7% were within +/- 5% of their measured weights. Accuracy of recall was significantly and independently associated with body mass index during middle age (5 kg/m(2)) (odds ratio 0.83, 95% confidence interval: 0.76, 0.90) and weight change. Unmarried men were less likely than married men to attempt recalling all 4 weights. Men overweight at middle age were more likely to underestimate their recalled weights. CONCLUSIONS: Studies relating weight in early adulthood or middle age with outcomes in later life should not rely on elderly male participants recalling those weights.