ABSTRACT
The topical anesthetic trimecaine given to rabbits in a dose of 10 mg/kg attenuated the severity of anaphylaxis, lowered the anaphylactic index, substantially reduced the rates of animals' death from anaphylactic shock. The drug used in a dose of 1 mg/kg slightly had effects on experimental anaphylaxis. Trimecaine affected the rabbit total lipid/phospholipid ratio which had its own specific features in intact, sensitized and anaphylactic animals. It is suggested that the antiallergic effects of trimecaine are associated with the ability of the agent to change the receptor characteristics of target cells in allergy enhanced by its interaction with lipid complexes of the cell membrane.
Subject(s)
Anaphylaxis/drug therapy , Trimecaine/administration & dosage , Anaphylaxis/blood , Animals , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Female , Immunization/methods , Lipids/blood , Lymphocytes/drug effects , Lymphocytes/metabolism , Male , RabbitsABSTRACT
In experiments on rabbits various effects of steroidal agents (hydrocortisone, deoxycorticosterone, beta-lipoproteids, cholesterol, saponins, digitoxin, strophanthin) on the development of sensitization and allergization at their administration during sensitization and before the resolving dose of the antigen were shown.
