[Can the presence of an RNA-lipoprotein complex in human blood serum give evidence of a cancerous disease?]. / Mozhet li prisutstvie RNK-lipoproteidnogo kompleksa v syvorotke krovi cheloveka svidetel'stvovat' ob onkologicheskom zabolevanii?

The fractional composition of serum lipoproteids in patients with malignant tumours and in noncancerous disorders as well as in healthy donors has been investigated to detect the cancer specificity of the appearance of the additional abnormal RNA-lipoprotein fraction. No distinct correlation is found between the presence of the additional serum lipoprotein fraction and human malignancy.

[Renal excretion of urea in the Merino and Steppe fat-tailed breeds of sheep after a short period of fasting]. / Renálna exkrécia mocoviny u oviec plemena merino a u stepných tucnochvostých oviec po krátkodobom hladovaní.

Urea excretion was studied in an experiment with two sheep breeds (steppe fat-tailed and merino) on the second day of fasting when the urea concentration in blood increases in fasting animals. The control group in the two breeds was given free-choice feed and water while fasting sheep were given ad libitum only water. Diuresis in both breeds was steady during the experiment. Glomerular filtration rate was not found to vary, in comparison with the control, although the plasma urea concentration rose in fat-tailed sheep (P less than 0.01) as well as in the sheep of merino breed (P less than 0.001). Fractional excretion of urea decreased in fat-tailed sheep (P less than 0.05) and also in the sheep of merino breed (P less than 0.02) while total output of urea remained steady in fat-tailed sheep but it increased in merino sheep (P less than 0.02). Tubular reabsorption of urea on the second day of fasting was observed to be higher by 65% in merino sheep (P less than 0.001), but in steppe fat-tailed sheep the increase was much higher--by up to 180% (P less than 0.001), in comparison with the control. It was demonstrated by the results that the increased tubular reabsorption of urea contributes to the rise of plasma urea concentration in sheep on the second day of fasting.

[Use of meradin for normalizing catecholamine metabolism in the rat hypothalamus at late periods following irradiation]. / Primenenie meradina dlia normalizatsii obmena katekholaminov v gipotalamuse krys v otdalennye sroki posle oblucheniia.

Meradine administered in a dose of 2 mg/kg during 10 days 10-12 months after irradiation with a dose of 4 Gy normalized the catecholamine metabolism in rat hypothalamus. The content of noradrenaline was restored as early as 24 h and that of DOPA and dopamine, 1 month after the cessation of meradine injection.

[Use of purine derivatives for normalizing the hypothalamic function of rats subjected to gamma-neutron irradiation]. / Primenenie proizvodnykh purina dlia normalizatsii funktsii gipotalamusa krys, podvergnutykh gamma-neitronnomu oblucheniiu.

In this work, the authors have made an attempt to correct pharmacologically the disorders in the regulatory function of hypothalamus caused by gamma/neutron-irradiation. For this purpose purine derivatives, ethymisol and meradin, were used. These preparations were effective in correcting fully or partially the postirradiation shifts in the balance between the hypothalamus mediators, catecholamines, and their biosynthetic precursor, dioxyphenylalanine (DOPA). In addition, meradin increased the firmness of the bone regenerator in the traumatized extremity of the animal.