[Neuromediator action on surfactant system activity and the functioning area of the lung]. / Deistvie neiromediatorov na aktivnost' surfaktantnoi sistemy i funktsioniruiushchuiu ploshchad' legkogo.

Experiments on rats have demonstrated the effect of neurotransmitter function on the activity of the surfactant system and functioning area of the lung (FAL). Excess transmitters gave rise to activation of the lung surfactant system and increase in the FAL, whereas the deficiency of transmitters lowered surfactant activity and the area of the air-blood barrier.

[Mechanisms of the antishock action of mebikar]. / Mekhanizmy protivoshokovogo deistviia mebikara.

The tranquilizer mebicar produces an antishock action, normalizes different links of mediator, acid-base and oxygen homeostasis. Mebicar decreases arterial pressure and the tone of peripheral vessels insignificantly and for a short period.

[Comparative evaluation of antishock activity of various Soviet pharmacological agents]. / Sravnitel'naia otsenka protivoshokovogo deistviia nekotorykh otechestvennykh farmakologicheskikh preparatov.

On the basis of experimental and clinical studies the authors recommend to use mebikar with promedol in complex with other drugs for the treatment of traumatic shock in the prehospital and hospital periods. It was found to substantially improve results of the antishock therapy.

[Effect of mebikar on the experimental and clinical course of traumatic shock]. / Vliianie mebikara na techenie travmaticheskogo shoka v éksperimente i klinike.

The effect of mebikar upon the course of traumatic shock was studied on the basis of experimental investigations and clinical observations. The authors have found a positive effect of the drug on indices of acid-base state, histostructure and cellular composition of the liver whose disturbance has a great pathogenetic significance in shock. The application of mebikar considerably improved the results of treatment in clinic and reduced lethality in experiment. It was supposed that the positive effect of the drug was associated with prevention of the development of circulatory disorders and with the maintenance of oxidation-reduction process and the histostructure of tissues.

[Effect of the acetylcholine system on the pathogenesis of pulmonary complications during the postshock period]. / Vliianie sistemy atsetilkholina na patogenez legochnykh oslozhnenii v postshokovom periode.

In the course of the postshock period the experimental animals show changes of two types both in acetylcholine metabolism and pulmonary histophysiology. Comparison of the evidence obtained revealed a relationship between these changes, thereby promoting purposeful therapy of pulmonary complications by means of propionylcholinesterase. Administration of the preparation before and after injury improved acetylcholine metabolism, favoured the recovery of the respiratory system function, as well as an increase in the life span and decrease in lethality of the experimental animals.

[Effect of neuromediators on acid-base status]. / Vliianie neiromediatorov na kislotno-shchelochnoe sostoianie.

A relationship between the state of adrenergic, cholinergic, and serotoninergic systems, on the one hand, and the acid-alkaline balance of the organism, on the other hand, was revealed in sharp and chronic experiments on dogs. A surplus of each of the mediators was accompanied by respiratory alkalosis, and its deficiency--by combined respiratory and metabolic acidosis.

[Neurohumoral correlations and the effect of hydrocortisone on respiratory function in experimental pancreatitis]. / Neirogumoral'nye vzaimootnosheniia i vliianie gidrokortizona na funktsiiu dykhaniia pri éksperimental'nom pankreatite.

From the observations on 18 patients and the experiments on 77 dogs with experimental pancreatitis neuro-humoral interrelations and hydrocortisone effect upon the respiratory function have been studied. Both in the clinic and in the experiment the authors have found the intermediate metabolism disturbed: adrenaline-like substances blood level rises, while the cholinergic complex blood level drops dramatically. The conclusion on a vital importance of a consecutive neuro-humoral correction with the use of cholinomimetics and corticosteroids in pancreatitis is drawn.

[Clinical physiological evaluation of the splenopancreatogastrectomy operation in stomach cancer patients]. / Kliniko-fiziologicheskaia otsenka operatsii splenopankreatogastroéktomii u bol'nykh rakom zheludka.

Clinico-physiological data on 52 patients after spleno-pancreatogastrectomy are analysed. The mortality was 25%, the late results were as follows: a 3-year survival--in 28%, a 5-year survival--in 14.7%, a 10-year survival--in 9%. This group of patients was examined for the functional state of the cholinergic system, carbohydrate metabolism, external respiration and basic metabolism. Carbohydrate metabolism is found to change but insignificantly and requires no corrective measures. The cholinergic system activity was reduced, that adversely affects the respiratory function and contributes to the decreased basic metabolism. The latter would necessitate including of cholinomimetics and lipocain in the scheme of the postoperative management.

[Role of the biological activity of serotonin in the production of the "shock lung" syndrome]. / Rol' biologicheskoi aktivnosti serotonina v formirovanii sindroma "shokovogo" legkogo.

The influence of the serotin biological activity on forming the "shock" lung syndrome was revealed in experiments on rats. Tachyhyperpnea with predominance of functional emphysema and a small number of atelectic tissue areas were observed in the animals with traumatic "shock" during the serotonin hypersecretion. Tachyhypopnea with a significant predominance of atelectiv areas was seen during the serotonin hypoproduction.