[Dynamics of changes in the protease-inhibitory balance in blood plasma of dogs with experimental acute pancreatitis]. / Dinamika izmenenii proteinazno-ingibitornogo balansa v plazme krovi sobak s éksperimental'nym ostrym pankreatitom.

Changes of proteinase-inhibitory system values in blood plasma of dogs with experimental acute pancreatitis (EAP) were studied in dynamics. Their diagnostic and prognostic values was appraised. Essential shifts were revealed in the proteinase-inhibitory balance in blood plasma of dogs with EAP of various severity. The concentration of trypsin- and chymotrypsin-like proteinases exceeded the normal values 1.8-3.3 times in these animals. Coefficients expressing the relation of antitryptic and antichymotryptic activities to the activities of the corresponding proteinases in the blood plasma of animals with EAP were indicative of diminished blood plasma inhibitory potential as compared to that in intact animals. The authors are the first to show the diagnostic and prognostic value of the antichymotryptic activity/chymotrypsin in blood plasma of dogs with EAP.

[Specific proteinase plasma sorption in surgery with artificial blood circulation]. / Spetsificheskaia plazmosorbtsiia proteinaz pri operatsiiakh s isskustvennym krovoobrashcheniem.

Cardiosurgery with artificial circulation (AC) is attended with activation of plasma cascade proteolytic systems, which leads to homeostatic disturbances and postoperative complications. AC with the use of specific proteinase plasma sorption in a column with sepharose-immobilized acid-base proteinase inhibitor from human urine prevents activation of proteinase in the plasma. Application of specific plasma sorption facilitates rapid restoration of the plasma protein concentration lowered during AC, improves the course of the postoperative period, and reduces the risk of pulmonary, cardiovascular, and nervous complications.

[Variants of procedures of artificial blood circulation and the proteinase activity of the blood]. / Varianty provedeniia iskusstvennogo krovoobrashcheniia i proteinaznaia aktivnost' plazmy krovi.

The use of a "Cell-Saver" technique prevented hyperproteolysis and deletion of proteinase inhibitors in the blood plasma of patients during cardiopulmonary bypass. The technique also improved the course of the postoperative period, decreased the incidence of lung complications and prevented effectively postoperative bleedings. A prognostic value of alpha 1-proteinase inhibitor to trypsin activity ratio in the blood plasma of patients subject of cardiopulmonary bypass surgery has been demonstrated.

[Correction (in vitro) of proteinase inhibitor balance in the blood of patients after cardiosurgical interventions]. / Korrektsiia (in vitro) proteinazno-ingibitornogo ballansa v krovi bol'nykh posle kardiokhirurgicheskikh vmeshatel'stv.

Proteinase-inhibitor balance in human plasma before and after artificial blood circulation was examined. It was shown that trypsinlike and chemotrypsinlike proteinases activities after this procedure were 1.6 and 2.8 times higher and antitryptic activity 1.2 times lower than in the same patients before the procedure. The 40-50% decrease of proteinase activity in human plasma after artificial blood circulation was observed as a result of in vitro plasmasorption on immobilized human urinary trypsin inhibitor.