Subject(s)
Blood Coagulation , Burns/blood , Burns/diagnosis , Adolescent , Child , Child, Preschool , Female , Humans , Infant , MaleABSTRACT
In experiments on rats with cerebral ischemia (30-min occlusion of carotid arteries), the novel calcium antagonist Cerebrocrast (0.4 microgram.kg-1.min-1 i.v. for 15 min) was found to provide the functional maintenance of the parietal cerebral bed in the postischemic period by improving cerebral hemodynamics, reducing the number of highly narrowed capillaries. The agent prevented the erythrocytic accumulation of lipid peroxidation (LPO) products (diene conjugates and Schiff bases) in the intra- and postischemic periods, promoted the maintenance of viscoelastic properties during LPO activation.
Subject(s)
Calcium Channel Blockers/pharmacology , Cerebrovascular Circulation/drug effects , Dihydropyridines/pharmacology , Ischemic Attack, Transient/prevention & control , Vasodilator Agents/pharmacology , Acute Disease , Animals , Calcium Channel Blockers/therapeutic use , Cerebrovascular Circulation/physiology , Dihydropyridines/therapeutic use , Drug Evaluation, Preclinical , Ischemic Attack, Transient/metabolism , Ischemic Attack, Transient/physiopathology , Lipid Peroxidation/drug effects , Male , Microcirculation/drug effects , Microcirculation/physiology , Rats , Vasodilator Agents/therapeutic useABSTRACT
Acute cerebral ischemia in cats (both carotid arteries occlusion during 30 min after permanent occlusion of both vertebral arteries) was accompanied by postischemic hypoperfusion and hypo-oxygenation of the cerebral tissue. Intravenous infusion of cerebrocrast (1 micrograms.kg-1.min-1 during 60 min) prevented manifestation of the postischemic phenomena. Antihypoxic effect of cerebrocrast involved the cerebral blood flow increase, brain oxygen consumption lowering and Hb-O2-affinity decrease.
Subject(s)
Calcium Channel Blockers/therapeutic use , Dihydropyridines/therapeutic use , Ischemic Attack, Transient/drug therapy , Vasodilator Agents/therapeutic use , Acute Disease , Animals , Brain/drug effects , Brain/metabolism , Cats , Drug Evaluation, Preclinical , Female , Hemodynamics/drug effects , Ischemic Attack, Transient/physiopathology , Male , Oxygen Consumption/drug effects , Time FactorsABSTRACT
Influence of natrii hydroxybutyrate (100 mg/kg), ascorbate (100 mg/kg), cavinton (5 mg/kg), bemitil (50 mg/kg), ethomersol (50 mg/kg) on Hb-O2 affinity and cortex PO2 after both carotid artery occlusion in rats was investigated. Correlation (r-0.87; P less than 0.05) between lowering of Hb-O2 affinity and antihypoxic effect was demonstrated in the line of these drugs.
