ABSTRACT
Noninvasive NMR measurement of human tissues, such as fingers, to achieve early detection for metabolic diseases is of important significance. The NMR relaxation measurements have a wide application prospect due to simplicity, portability, and low cost, as the static magnetic field is not required to be highly homogeneous. However, the inhomogeneous radiofrequency (RF) magnetic field (B1) results in errors in the magnetic resonance relaxation times. This is inevitable in in-vivo localized human tissue measurements with a portable MR scanner, as signals from tissues close to the edge of RF coil are excited with a different B1 field amplitude. A novel RF coil termed T coil with high B1 field homogeneity is presented. Numerical simulation and phantom measurements were implemented. The novel RF coil was compared with a regular solenoid coil and a variable width coil. In-vivo experiments were performed. The T coil has a better B1 field homogeneity than the regular solenoid coil and the variable width coil, producing more accurate magnetic resonance relaxation times. Improved detection accuracy has been achieved with the T coil. This work may promote the development of noninvasive human tissue diagnosis based on NMR relaxation methods.
