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1.
Conf Proc IEEE Eng Med Biol Soc ; 2004: 1325-8, 2004.
Article in English | MEDLINE | ID: mdl-17271936

ABSTRACT

Arterial stenoses are often associated with audible bruits. Quantitative analysis of the bruit spectrum has been successfully used to predict the residual lumen diameter in carotid stenoses. Arterial wall vibrations occurring due to turbulent pressure fluctuations in the post-stenotic jet are known to be the source of the bruits. We present novel signal processing techniques that enable the detailed noninvasive assessment of these vibrations in real time using color-Doppler and pulsed-wave Doppler ultrasound. A color-Doppler-based two-dimensional vibration imaging technique can be used to locate the source of the bruits relative to the underlying anatomy. Subsequently, a pulsed-wave Doppler-based technique can be used to analyze the bruit spectrum quantitatively. Experiments in ex vivo arteries indicate that these techniques can predict the location of the bruit as well as its spectral content. Case studies on human subjects with stenosed vein grafts are presented and the clinical applicability of this technique is discussed.

2.
Radiology ; 221(2): 285-99, 2001 Nov.
Article in English | MEDLINE | ID: mdl-11687667

ABSTRACT

Measurement of vessel stenosis by using ultrasonography or angiography remains the principal method for determining the severity of carotid atherosclerosis and the need for endarterectomy. The ipsilateral stroke rate, however--even in patients with severely stenotic vessels--is relatively low, which suggests that the amount of luminal narrowing may not represent the optimal means of assessing clinical risk. As a result, some patients may undergo unnecessary surgery. Improved imaging techniques are, therefore, needed to enable reliable identification of high-risk plaques that lead to cerebrovascular events. High-spatial-resolution magnetic resonance (MR) imaging has been described as one promising modality for this purpose, because the technique allows direct visualization of diseased vessel wall and can be used to characterize the morphology of individual atherosclerotic carotid plaques. The purpose of this report is to review the current state of carotid plaque MR imaging and the use of carotid MR to evaluate plaque morphology and composition.


Subject(s)
Carotid Artery Diseases/diagnosis , Magnetic Resonance Angiography , Carotid Artery Diseases/diagnostic imaging , Humans , Magnetic Resonance Angiography/instrumentation , Magnetic Resonance Angiography/methods , Necrosis , Reproducibility of Results , Ultrasonography
3.
Ultrasound Med Biol ; 27(8): 1049-58, 2001 Aug.
Article in English | MEDLINE | ID: mdl-11527591

ABSTRACT

It is known that bruits often can be heard downstream from stenoses. They are thought to be produced by disturbed blood flow and vessel wall vibrations. Our understanding of bruits has been limited, though, to analysis of sounds heard at the level of the skin. For direct measurements from the stenosis site, we developed an ultrasonic pulse-echo multigate system using quadrature phase demodulation. The system simultaneously measures tissue displacements and blood velocities at multiple depths. This paper presents a case study of a severe stenosis in a human infrainguinal vein bypass graft. During systole, nearly sinusoidal vessel wall vibrations were detected. Solid tissue vibration amplitudes measured up to 2 microm, with temporal durations of 100 ms and frequencies of roughly 145 Hz and its harmonics. Cross-axial oscillations were also found in the lumen that correlate with the wall vibrations, suggesting coupling between wall vibration and blood velocity oscillation.


Subject(s)
Peripheral Vascular Diseases/diagnostic imaging , Blood Flow Velocity , Constriction, Pathologic/diagnostic imaging , Graft Occlusion, Vascular/diagnostic imaging , Humans , Ultrasonography , Vibration
4.
J Vasc Surg ; 33(4): 700-7, 2001 Apr.
Article in English | MEDLINE | ID: mdl-11296320

ABSTRACT

OBJECTIVE: Accurate measurements of abdominal aortic aneurysms (AAAs) are required for surgical planning and monitoring over time. We have examined the feasibility of using a three-dimensional (3-D) ultrasound imaging system to derive quantitative measurements of interest from AAAs. METHODS: A normal aorta, a small AAA, and an AAA repaired with an endovascular stent graft were scanned with a 3-D ultrasound imaging system. For each case, a 3-D surface reconstruction was generated from manual outlines of a sequence of two-dimensional ultrasound images, registered in 3-D space with a magnetic tracking system. The surfaces were resampled in planes perpendicular to the vessel center axis to calculate cross-sectional area and maximum diameter as a function of distance along the length of the aorta. RESULTS: Cross-sectional area and maximum diameter were plotted along the length of the aneurysmal aortas from the renal arteries to the aortic bifurcation. The overall maximum diameter was found for both aneurysms. For the small AAA, the distances of the aneurysm from the renal arteries and the bifurcation were measured. For the repaired AAA, the location of the stent graft relative to the renal arteries was measured. CONCLUSIONS: 3-D surface reconstructions from ultrasound images show promise for quantitatively characterizing the geometry of AAAs both before surgery and after endovascular repair.


Subject(s)
Aortic Aneurysm, Abdominal/diagnostic imaging , Imaging, Three-Dimensional , Aorta, Abdominal/diagnostic imaging , Aortic Aneurysm, Abdominal/surgery , Blood Vessel Prosthesis Implantation , Feasibility Studies , Humans , Stents , Ultrasonography/instrumentation , Ultrasonography/methods
5.
Ultrasound Med Biol ; 27(1): 61-8, 2001 Jan.
Article in English | MEDLINE | ID: mdl-11295271

ABSTRACT

Frequent surveillance of bypass grafts placed in the lower limbs can provide early detection of stenoses. A three-dimensional (3-D) ultrasound (US) imaging system has been used to produce serial surface reconstructions of regions of interest in vein grafts in the lower extremities. Using anatomical reference points, data sets from serial studies are registered in a common 3-D coordinate system. Cross-sectional area measurements are extracted from the surface reconstructions in planes normal to the vessel center axis. These measurements are compared at matched sites over time to track changes in the vessel configuration. The quantitative measurements are paired with surface displays of the vessels for a complete depiction of the changing geometry. Example studies from three patients are shown, for time periods up to 38 weeks. The cross-sectional area measurements highlight regions of remodeling and developing stenoses within the grafts.


Subject(s)
Arterial Occlusive Diseases/surgery , Blood Vessel Prosthesis , Imaging, Three-Dimensional , Leg/blood supply , Leg/diagnostic imaging , Ultrasonography, Doppler , Adult , Aged , Female , Humans , Image Processing, Computer-Assisted , Male , Reproducibility of Results
6.
Ultrasound Med Biol ; 26(8): 1213-35, 2000 Oct.
Article in English | MEDLINE | ID: mdl-11120358

ABSTRACT

Combining Doppler measurements taken along multiple intersecting ultrasound (US) beams is one approach to obtaining angle-independent velocity. Over 30 laboratories and companies have developed such cross-beam systems since the 1970s. Early designs focused on multiple single-element probes. In the late 1980s, combining multiple color Doppler images acquired from linear-array transducers became a popular modality. This was further expanded to include beam steering and the use of subapertures. Often, with each change in design, came a new twist to calculating the velocity. This article presents a review of most proposed cross-beam systems published to date. The emphasis is on the basic design, the approach used to determine the angle-independent velocity, the advantages of the design, and the disadvantages of the design. From this, requirements needed to convert the idea of angle-independent vector Doppler into a commercial system are suggested.


Subject(s)
Ultrasonography, Doppler/methods , Blood Flow Velocity , Rheology , Transducers , Ultrasonography, Doppler/instrumentation
7.
Am J Med ; 109(5): 351-6, 2000 Oct 01.
Article in English | MEDLINE | ID: mdl-11020390

ABSTRACT

PURPOSE: The cause of many cases of sudden cardiac arrest from pulseless electrical activity is unknown. We hypothesized that pulmonary embolism was responsible for a substantial proportion of these cases and used transesophageal echocardiography to identify pulmonary embolism among patients with sudden cardiac arrest. SUBJECTS AND METHODS: We performed a prospective study at a tertiary care, university-operated county hospital, with a level 1 trauma center. Consecutive patients (n = 36) who were admitted with (n = 20) or unexpectedly developed (n = 16) sudden cardiac arrest of unknown cause were studied with transesophageal echocardiography during cardiopulmonary resuscitation. We determined the presence of central pulmonary embolism, right ventricular enlargement, and other causes of sudden cardiac arrest (such as myocardial infarction and aortic dissection) using prospectively defined criteria. RESULTS: Of the 25 patients with pulseless electrical activity as the initial event, 9 (36%) had pulmonary emboli (8 seen with transesophageal echocardiography and 1 diagnosed at autopsy) compared with none of the 11 patients with other rhythms, such as asystole or ventricular tachycardia or fibrillation (P = 0.02). Of the 8 patients who had pulmonary embolism diagnosed by transesophageal echocardiography, 2 survived to hospital discharge. CONCLUSIONS: Mortality from massive pulmonary embolism is high, particularly if patients present with sudden cardiac arrest. Earlier diagnosis of pulmonary embolus may permit wider use of thrombolytic agents or other interventions and may potentially increase survival.


Subject(s)
Echocardiography, Transesophageal , Heart Arrest/diagnostic imaging , Heart Arrest/etiology , Pulmonary Embolism/complications , Pulmonary Embolism/epidemiology , Aged , Cardiopulmonary Resuscitation , Diagnosis, Differential , Electrocardiography , Female , Heart Arrest/therapy , Hospitals, University , Humans , Incidence , Male , Middle Aged , Northwestern United States/epidemiology , Prospective Studies , Pulmonary Embolism/diagnostic imaging , Pulmonary Embolism/mortality , Pulse
8.
Circulation ; 98(24): 2666-71, 1998 Dec 15.
Article in English | MEDLINE | ID: mdl-9851951

ABSTRACT

BACKGROUND: Current imaging modalities, such as contrast angiography, accurately determine the degree of luminal narrowing but provide no direct information on plaque size. Magnetic resonance imaging (MRI), however, has potential for noninvasively determining arterial wall area (WA). This study was conducted to determine the accuracy of in vivo MRI for measuring the cross-sectional maximum wall area (MaxWA) of atherosclerotic carotid arteries in a group of patients undergoing carotid endarterectomy. METHODS AND RESULTS: Fourteen patients scheduled for carotid endarterectomy underwent preoperative carotid MRI using a custom-made phased-array coil. The plaques were excised en bloc and scanned using similar imaging parameters. MaxWA measurements from the ex vivo MRI were used as the reference standard and compared with MaxWA measurements from the corresponding in vivo MR study. Agreement between the in vivo and ex vivo measurement was analyzed using the Bland-Altman method. The paired in vivo and ex vivo MaxWA measurements strongly agreed: the mean difference (in vivo minus ex vivo) in MaxWA was 13.1+/-6.5 mm2 for T1-weighted (T1W) imaging (mean MaxWA in vivo=94.7 mm2, ex vivo=81.6 mm2) and 14.1+/-11.7 mm2 for proton density-weighted (PDW) imaging (mean MaxWA in vivo=93.4 mm2, ex vivo=79.3 mm2). Intraobserver and interobserver variability was small, with intraclass correlation coefficients ranging from 0.90 to 0.98. CONCLUSIONS: MRI is highly accurate for in vivo measurement of artery WA in atherosclerotic carotid lesions. This imaging technique has potential application monitoring lesion size in studies examining plaque progression and/or regression.


Subject(s)
Arteriosclerosis/diagnosis , Carotid Artery Diseases/diagnosis , Magnetic Resonance Imaging , Carotid Artery, Common/pathology , Carotid Artery, Internal , Endarterectomy, Carotid , Humans , Reference Standards , Reproducibility of Results
9.
Arch Intern Med ; 158(7): 761-7, 1998 Apr 13.
Article in English | MEDLINE | ID: mdl-9554682

ABSTRACT

BACKGROUND: Atherosclerotic lesions of the carotid and lower extremity arteries may be associated with renal artery stenosis and influence the management of patients with renal artery disease. OBJECTIVE: To document the prevalence and clinical features of carotid and lower extremity arterial disease in patients with renal artery atherosclerosis. METHODS: An analysis of baseline data on 149 patients enrolled in a prospective natural history study of atherosclerotic renal artery stenosis. Patients with at least 1 abnormal renal artery by duplex scanning were eligible. Carotid artery disease was evaluated by duplex scanning, and ankle/brachial indices were used to assess the lower extremity arteries. Disease at each of the 3 arterial sites was classified as mild, moderate, or severe based on the extent of involvement on both sides. Serum urea nitrogen, creatinine, and lipid levels were also measured. RESULTS: Severe renal, carotid, or lower extremity arterial disease was present in 44%, 19%, and 21% of the patients, respectively. There was a trend for patients with increasing degrees of renal artery disease to have increasing degrees of carotid and lower extremity arterial disease. The prevalence of severe carotid artery disease increased from 7% in the mild renal artery group to 28% in the severe renal artery group. Clinical factors that were most predictive of severe disease were elevated apolipoprotein B levels for the renal arteries, high serum urea nitrogen or creatinine levels for the carotid arteries, and smoking for the lower extremity arteries. CONCLUSIONS: There was a strong association between severe renal artery atherosclerosis and severe carotid artery disease. Patients with renal artery disease also had a high prevalence of lower extremity arterial disease. In this patient population, screening for lower extremity arterial disease can be reserved for those with signs or symptoms of peripheral ischemia. Noninvasive carotid screening is justified in patients with renal artery disease to detect asymptomatic lesions that require either immediate surgical treatment or serial follow-up for disease progression.


Subject(s)
Carotid Stenosis/complications , Leg/blood supply , Renal Artery Obstruction/complications , Aged , Arterial Occlusive Diseases/complications , Carotid Stenosis/diagnostic imaging , Female , Humans , Leg/diagnostic imaging , Male , Middle Aged , Prevalence , Renal Artery Obstruction/diagnostic imaging , Severity of Illness Index , Ultrasonography
10.
Kidney Int ; 53(3): 735-42, 1998 Mar.
Article in English | MEDLINE | ID: mdl-9507221

ABSTRACT

The goal of this study was to determine the incidence of and risk factors for renal atrophy among kidneys with atherosclerotic renal artery stenosis (ARAS). Participants with at least one ARAS were followed prospectively with duplex scans performed every six months. Renal atrophy was defined as a reduction in renal length of greater than 1 cm. A total of 204 kidneys in 122 subjects were followed for a mean of 33 months. The two-year cumulative incidence (CI) of renal atrophy was 5.5%, 11.7%, and 20.8% in kidneys with a baseline renal artery disease classification of normal, <60% stenosis, and > or = 60% stenosis, respectively (P = 0.009, log rank test). Other baseline factors associated with a high risk of renal atrophy included a systolic blood pressure > 180 mm Hg (2-year CL = 35%, P = 0.01), a renal artery peak systolic velocity > 400 cm/second (2-year CI = 32%, P = 0.02), and a renal cortical end diastolic velocity < or = 5 cm/second (2-year CI = 29%, P = 0.046). The number of kidneys demonstrating atrophy per participant was correlated with elevations in the serum creatinine concentration (P = 0.03). In patients with ARAS, there is a significant risk of renal atrophy among kidneys exposed to elevated systolic blood pressure and among those with high-grade ARAS and low renal cortical blood flow velocity as assessed by renal duplex scanning. The occurrence of renal atrophy is well-correlated with changes in the serum creatinine concentration.


Subject(s)
Arteriosclerosis/complications , Arteriosclerosis/pathology , Kidney/pathology , Renal Artery Obstruction/complications , Renal Artery Obstruction/pathology , Aged , Arteriosclerosis/physiopathology , Atrophy/etiology , Blood Pressure , Creatinine/blood , Female , Humans , Kidney/diagnostic imaging , Male , Middle Aged , Prospective Studies , Renal Artery/diagnostic imaging , Renal Artery Obstruction/physiopathology , Renal Circulation , Risk Factors , Ultrasonography
11.
AJNR Am J Neuroradiol ; 19(1): 129-34, 1998 Jan.
Article in English | MEDLINE | ID: mdl-9432170

ABSTRACT

PURPOSE: We assessed the performance of T2-weighted MR imaging in detecting atherosclerotic fibrous caps and in depicting their integrity. METHODS: Twenty atherosclerotic lesions removed by carotid endarterectomy were imaged on a 1.5-T system using T2-weighted spin-echo sequences. The MR images were reviewed independently by four blinded interpreters for fibrous caps and ruptures. The results obtained from the observers were then graded against histologic findings by using receiver-operating characteristic (ROC) curve analysis. RESULTS: The area under the ROC curve for fibrous cap detection was 0.80, indicating that T2-weighted MR imaging was a good but not definitively diagnostic test for detecting ex vivo fibrous caps. The ROC curve for fibrous cap characterization yielded an area of 0.75, indicating that T2-weighted MR imaging was a fair but not highly diagnostic test for depicting fibrous cap integrity. A definite reading for detection of fibrous caps or rupture was fairly specific (90% and 98%, respectively) but not very sensitive (37% and 12%, respectively). CONCLUSIONS: T2-weighted MR imaging of ex vivo atherosclerotic plaques aided in the detection and evaluation of fibrous caps. In both cases, MR imaging proved more useful for ruling out disease than for confirming its presence.


Subject(s)
Arteriosclerosis/diagnosis , Carotid Artery Thrombosis/diagnosis , Magnetic Resonance Imaging , Arteriosclerosis/pathology , Carotid Artery Thrombosis/pathology , Clinical Competence , Endarterectomy, Carotid , False Positive Reactions , Humans , Magnetic Resonance Imaging/methods , Observer Variation , ROC Curve , Sensitivity and Specificity
12.
Ultrasound Med Biol ; 24(9): 1313-24, 1998 Nov.
Article in English | MEDLINE | ID: mdl-10385954

ABSTRACT

A severe arterial occlusion in the leg usually is bypassed by implanting a saphenous vein harvested from the limb. Once implanted, the vein functions well but over time may develop stenoses that may lead to occlusion. In order to detect and correct the stenoses that may lead to graft failure, frequent surveillance of the vein graft is required. A new ultrasound imaging method was developed to display the panoramic view of the vein graft in combination with its blood flow velocity waveform for surveillance. The panoramic view is the projection (ray-casting) image of multiple B-mode images with sequential longitudinal view of the vein graft. The velocity waveform also is recorded along the vessel with pulsed Doppler ultrasound. The acquired images and waveforms from the ultrasound scanner are registered individually in three-dimensional space with an electromagnet-based position and orientation sensor located on the scanhead. A prominent point on the scar from the surgery is used as the fiducial mark for spatial registration, so that the same lesion in the vein graft can be tracked automatically at each visit for retrospective study.


Subject(s)
Graft Occlusion, Vascular/diagnostic imaging , Saphenous Vein/diagnostic imaging , Saphenous Vein/transplantation , Ultrasonography, Doppler, Duplex , Arterial Occlusive Diseases/diagnostic imaging , Arterial Occlusive Diseases/surgery , Blood Flow Velocity/physiology , Humans , Leg/blood supply
13.
Gastroenterology ; 113(1): 38-49, 1997 Jul.
Article in English | MEDLINE | ID: mdl-9207260

ABSTRACT

BACKGROUND & AIMS: Three-dimensional (3D) ultrasound imaging of the total stomach volume has not yet been achieved. The aim of this study was to investigate whether a magnetic position sensor system for acquisition of 3D ultrasonograms could be used to determine gastric emptying rates and intragastric distribution. METHODS: A system for position and orientation measurement was interfaced to an ultrasound scanner. In vitro accuracy was evaluated by scanning a porcine stomach. Fourteen volunteers, with a median age of 35 years, were scanned fasting and postcibally by two-dimensional (2D) and 3D ultrasound after ingesting a 500-mL soup meal. RESULTS: This 3D system yielded a strong correlation (r = 0.997) between true and estimated volumes in vitro. The limits of agreement were -9.1:70.1 mL in the volume range 1200-1900 mL. The intersubject variability of the total gastric volumes ranged from 12.5% to 46.0%, less than for antral area variability. The average half-emptying time was 22.1 +/- 3.8 minutes. Intragastric distribution of the meal, expressed as proximal distal volume, varied on average from 3.6 +/- 2.1 (5 minutes postpradially) to 2.7 +/- 1.9 (30 minutes postprandially). CONCLUSIONS: This 3D ultrasound system using magnetic scanhead tracking showed excellent in vitro accuracy, calculated gastric emptying rates more precisely than by 2D ultrasound, and enabled estimation of intragastric distribution of a soup meal.


Subject(s)
Gastric Emptying , Image Processing, Computer-Assisted/methods , Stomach/diagnostic imaging , Adult , Animals , Food , Gastric Emptying/physiology , Gastrointestinal Motility/physiology , Humans , Male , Swine , Time Factors , Ultrasonography
14.
Ultrasound Med Biol ; 23(3): 319, 1997.
Article in English | MEDLINE | ID: mdl-9160901
16.
Stroke ; 28(1): 95-100, 1997 Jan.
Article in English | MEDLINE | ID: mdl-8996496

ABSTRACT

BACKGROUND AND PURPOSE: Studies have suggested that B-mode ultrasonography can be used to determine carotid plaque composition and that specific plaque characteristics are associated with a worse clinical outcome. However, histological studies examining the relationship between carotid plaque morphology and clinical outcome have reported conflicting findings. Furthermore, few investigators have described plaque morphology in quantifiable terms. This study examines the association between the volume of carotid plaque constituents and preoperative ischemic neurological symptoms. Constituents examined were chosen based on their potential for identification by current diagnostic imaging modalities such as ultrasound or MRI. METHODS: Atherosclerotic plaques from 43 patients undergoing carotid endarterectomy were examined histologically, with sections obtained every 0.5 to 1 mm. The lesions were examined for the presence and quantity of fibrous intimal tissue, intraplaque hemorrhage, lipid core, necrotic plaque core, and calcification. The quantity of each constituent was compared in plaques removed from symptomatic patients with those excised from asymptomatic individuals. Differences were analyzed with a Kolmogorov-Smirnov statistic. RESULTS: There was no difference between plaques removed from asymptomatic and symptomatic patients with regard to the presence and volume of fibrous intimal tissue, intraplaque hemorrhage, the lipid core, the necrotic core, or calcification. CONCLUSIONS: In patients with highly stenotic carotid lesions who are undergoing carotid endarterectomy, gross plaque composition is similar regardless of preoperative symptom status. Given this similarity, it is unlikely that differences in the volume of intraplaque hemorrhage, lipid core, necrotic core, or calcification in atherosclerotic carotid plaques explain their embolic history.


Subject(s)
Carotid Arteries/pathology , Carotid Stenosis/pathology , Aged , Aged, 80 and over , Calcinosis , Carotid Stenosis/surgery , Cerebrovascular Disorders/pathology , Endarterectomy, Carotid , Female , Hemorrhage , Humans , Male , Middle Aged , Necrosis , Tunica Intima/pathology
17.
J Vasc Surg ; 23(3): 394-400, 1996 Mar.
Article in English | MEDLINE | ID: mdl-8601880

ABSTRACT

PURPOSE: Our purpose was to investigate the hemodynamic theory that the blood flow rate through a stenotic arterial graft is limited by the onset of turbulence, which acts as a barrier at peak systole against further increases in systolic flow. METHODS: We used duplex ultrasonography to examine 25 stenotic infrainguinal vein grafts. Theory predicts that the flow limitation occurs at peak systole at a stenotic velocity greater than 250 cm/sec, which corresponds to a residual stenotic lumenal diameter of 0.36 cm (Reynolds No. 2000). These numbers are based on the assumption that the 68 ml/min blood flow is supplied by the femoropopliteal graft to the resting lower leg only during systole. When the lumen is smaller than 0.36, peak systolic velocity (PSV) must exceed 250 cm/sec. The increased velocity results in poststenotic turbulence. This turbulent condition restricts the average graft systolic flow to less than the 68 ml/min required by the lower leg, so diastolic flow is needed to make up the deficit. RESULTS: Twenty vein grafts with PSVs of 250 cm/sec or greater had end-diastolic velocities of 50 cm/sec or greater as predicted; three grafts with PSVs of 256 to 300 cm/sec and two grafts with PSVs of less than 250 cm/sec had no forward diastolic flow. CONCLUSION: The onset of turbulence in a stenotic vein graft supplying the lower leg occurs at a PSV of 250 cm/sec or greater. The appearance of diastolic flow maintains the average graft volume flow.


Subject(s)
Graft Occlusion, Vascular/physiopathology , Leg/blood supply , Systole/physiology , Veins/transplantation , Blood Flow Velocity , Femoral Artery/physiopathology , Graft Occlusion, Vascular/diagnostic imaging , Humans , Regional Blood Flow , Ultrasonography, Doppler, Color , Veins/diagnostic imaging , Veins/physiopathology
18.
Ann Vasc Surg ; 9(6): 554-60, 1995 Nov.
Article in English | MEDLINE | ID: mdl-8746833

ABSTRACT

The relationship between the measured arm-ankle pressure difference (AAPD), or the ankle/arm index (AAI), and the focal peak systolic velocity (PSV) at stenotic sites of infrainguinal vein grafts has not been determined. We attempted to relate these two parameters. We used Doppler systolic pressures and duplex ultrasonography to study 35 infrainguinal vein bypass grafts followed in a surveillance protocol. The following graft groups were identified: grafts in nondiabetic patients (n = 26), grafts in diabetic patients (n = 9), nonrevised stenotic grafts (n = 14), revised stenotic grafts (n = 14), and normal grafts (n = 7). AAPD and AAI were measured in both lower extremities. Pressure gradients across graft stenoses were indirectly estimated using the modified Bernoulli equation (delta P =4V2). Measured AAPDs and estimated pressure gradients showed moderate correlation in nondiabetic (r = 0.58) and diabetic (r = 0.63) patients. Correlation was fair (r = 0.3) prior to graft revision. There was no correlation (r = 0.1) in the nonrevised stenotic grafts. For individual patients with stenotic grafts who were followed in consecutive visits, the correlation varied from none to good (r range 0.01 to 0.71). We conclude that there is a lack of consistent correlation between the measured AAPD, or AAI, and the estimated stenotic graft pressure gradient. This finding illustrates the limitation of the AAI as a monitoring test to predict failure of stenotic infrainguinal vein grafts.


Subject(s)
Ankle/blood supply , Arm/blood supply , Arteriosclerosis/surgery , Blood Pressure/physiology , Graft Occlusion, Vascular/diagnostic imaging , Ischemia/surgery , Leg/blood supply , Veins/transplantation , Arteriosclerosis/diagnostic imaging , Diabetic Angiopathies/diagnostic imaging , Diabetic Angiopathies/surgery , Follow-Up Studies , Graft Occlusion, Vascular/surgery , Humans , Ischemia/diagnostic imaging , Postoperative Complications/diagnostic imaging , Postoperative Complications/surgery , Prosthesis Failure , Reoperation , Ultrasonography, Doppler, Color
19.
Am J Card Imaging ; 9(3): 149-56, 1995 Jul.
Article in English | MEDLINE | ID: mdl-7549354

ABSTRACT

A histologic method was developed for three-dimensional (3-D) analysis of atherosclerotic plaques removed from the carotid bifurcation during endarterectomy. By sectioning the plaque at frequent intervals (0.5 to 1.0 mm), it is possible to obtain important information on plaque constituents with regard to their volume and distribution within the lesion. These data from each section are combined with those from other sections and displayed in a 3-D format for the entire length of the lesion. The tissues making up each of the 10 carotid plaques were outlined and digitized for each histologic section by position along the lesion. From the areas outlined a 3-D model was created by a computer-aided design program. Quantitative information on tissue distribution within the plaque was measured. Fibrous tissue constituted between 35% and 70% of plaque volume; loose necrosis from 0.5% to 30% of the plaque and thrombus occupied, at a maximum, 10% even though if was present in six of the 10 plaques. To investigate the distribution of constituents about the long axis, measurements were also made from each of the four quadrants of each section. The reproducibility of the measurements of three sets of sections at 10-mm separation showed that estimates of the amount of some constituents were very reproducible whereas others had considerable variation related to the small volume they occupied within the lesion. By generating a complete 3-D reproduction of the contents of atherosclerotic plaques, it may be possible to identify those features of the plaque that are most responsible for the development of ischemic events.


Subject(s)
Arteriosclerosis/pathology , Carotid Stenosis/pathology , Image Processing, Computer-Assisted , Arteriosclerosis/surgery , Brain Ischemia/etiology , Calcinosis/pathology , Carotid Artery Thrombosis/pathology , Carotid Stenosis/surgery , Cholesterol , Collagen , Computer-Aided Design , Data Display , Endarterectomy, Carotid , Fibrosis , Foam Cells/pathology , Hemorrhage/pathology , Humans , Necrosis , Reproducibility of Results , Signal Processing, Computer-Assisted , Tissue Embedding , Tunica Intima/pathology , Ulcer/pathology , Video Recording
20.
Ann Vasc Surg ; 9(2): 163-71, 1995 Mar.
Article in English | MEDLINE | ID: mdl-7786702

ABSTRACT

We developed a theoretic model of arterial stenosis to study the relationship between perfusion pressure and regional hemodynamics in stenotic infrainguinal vein grafts in an attempt to identify grafts at high risk for failure. Our model was based on the concept of energy and mass conservation of the flowing blood. We used the modified Bernoulli equation (delta P = 4 delta V2) to calculate the maximum possible intrastenotic peak systolic velocity (PSV) from the systolic blood pressure. PSV was measured by means of duplex ultrasonography in infrainguinal bypasses up to the time of revision (nine grafts) or spontaneous thrombosis (two grafts). We related arm systolic blood pressure, intrastenotic PSV, and prestenotic PSV obtained from duplex examinations conducted prior to graft thrombosis or revision and applied our model to these stenotic vein grafts. Intrastenotic PSV was consistently lower than maximum PSV predicted from the Bernoulli equation. The highest measured intrastenotic PSV of 600 cm/sec would require a minimum perfusion pressure of 144 mm Hg. The lowest measured PSV (20 cm/sec) was considered the minimum "thrombotic threshold velocity." This model predicts that for parabolic profile flow in an 80% diameter-reducing axisymmetric stenosis (96% cross-sectional area reduction), a prestenotic PSV of 20 cm/sec would produce an intrastenotic PSV of 500 cm/sec requiring the equivalent potential energy of 100 mm Hg systolic blood pressure. Our theory implies that in patients with nocturnal hypotension thrombosis of stenotic vein grafts may occur.


Subject(s)
Graft Occlusion, Vascular/physiopathology , Inguinal Canal/blood supply , Blood Flow Velocity , Blood Pressure , Graft Occlusion, Vascular/etiology , Hemodynamics , Humans , Hypotension/complications , Models, Cardiovascular , Risk Factors , Thrombosis/etiology , Thrombosis/physiopathology , Veins/transplantation
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