1.
Res Commun Chem Pathol Pharmacol
; 13(3): 401-9, 1976 Mar.
Article
in English
| MEDLINE
| ID: mdl-935632
ABSTRACT
Fenfluramine produces dose-related hyperthermia and behavioral stimulation in rabbits following intravenous administration. Both responses were antagonized by pretreatment with cinanserin, cyproheptadine, or fluxetine. Methergoline likewise abolished the stimulatory effect of fenfluramine and produced a partial blockade of the hyperthermia. Haloperidol was ineffective as a fenfluramine antagonist. This study demonstrates that fenfluramine-induced hyperthermia and stimulation in the rabbit result from an indirect action upon serotonergic receptors.
Subject(s)
Behavior, Animal/drug effects , Fenfluramine/pharmacology , Fever/chemically induced , Animals , Body Temperature/drug effects , Cinanserin/pharmacology , Cyproheptadine/pharmacology , Dose-Response Relationship, Drug , Fenfluramine/administration & dosage , Fenfluramine/antagonists & inhibitors , Haloperidol/pharmacology , Male , Metergoline/pharmacology , Phenyl Ethers/pharmacology , Propylamines/pharmacology , Rabbits , Receptors, Adrenergic/drug effects , Receptors, Drug/drug effects , Serotonin/physiology
2.
J Pharm Pharmacol
; 28(2): 170-2, 1976 Feb.
Article
in English
| MEDLINE
| ID: mdl-6684
3.
Proc West Pharmacol Soc
; 19: 100-1, 1976.
Article
in English
| MEDLINE
| ID: mdl-995971
Subject(s)
Amphetamines/pharmacology , Body Temperature/drug effects , Fenfluramine/pharmacology , Quinolines/pharmacology , p-Chloroamphetamine/pharmacology , Animals , Fenfluramine/antagonists & inhibitors , In Vitro Techniques , Male , Piperazines/antagonists & inhibitors , Piperazines/pharmacology , Quinolines/antagonists & inhibitors , Rabbits , Receptors, Serotonin/drug effects , Stimulation, Chemical , p-Chloroamphetamine/antagonists & inhibitors
4.
Proc West Pharmacol Soc
; 18: 41-2, 1975.
Article
in English
| MEDLINE
| ID: mdl-1178705
5.
