ABSTRACT
Acquired tumours of the nonpigmented ciliary body epithelium are rare. We present herein a case of low-grade adenocarcinoma in order to stress the problems related to the clinical diagnosis. The tumour in our case was circumscribed, localised on the ciliary body, and nonpigmented. The height of the tumour, measured with ultrasound biomicroscopy, was 3.5 mm. The internal reflectivity of the tumor was homogeneous with low attenuation. The tumour was surgically excised with an uneventful iridocyclectomy. Both clinical presentation and preoperative examinations allowed to circumscribe the correct diagnosis which could be confirmed only with histology.
Subject(s)
Adenocarcinoma/diagnosis , Adenocarcinoma/surgery , Ciliary Body/surgery , Uveal Neoplasms/diagnosis , Uveal Neoplasms/surgery , Adult , Ciliary Body/pathology , Humans , Male , Ophthalmologic Surgical Procedures , Treatment OutcomeABSTRACT
133 cases of uveal metastasis were reviewed. The study included 97 women and 36 men, aged 10 to 80 (mean 53.1). Breast carcinoma in women and lung carcinoma in men were the primary malignancies, which most frequently led to uveal metastasis. Metastasis from lung carcinoma were often diagnosed before the primary tumor. Survival from ocular diagnosis to death depends on the histological type of the primary tumor.
Subject(s)
Uveal Neoplasms/secondary , Adolescent , Adult , Aged , Aged, 80 and over , Breast Neoplasms/diagnosis , Breast Neoplasms/mortality , Child , Cross-Sectional Studies , Diagnosis, Differential , Female , Follow-Up Studies , Humans , Incidence , Lung Neoplasms/diagnosis , Lung Neoplasms/mortality , Male , Middle Aged , Survival Rate , Switzerland/epidemiology , Uveal Neoplasms/diagnosis , Uveal Neoplasms/mortalityABSTRACT
A 46-year-old white male patient in good general health presented with a bilateral conjunctival and eyelid tumor and a wart at the tip of the fourth right finger. Impression cytology showed dysplasic cells with loss of cohesion and up to 4 nucleoli per nucleus. The excisional biopsy of the conjunctiva revealed a dysplasic epithelial tissue that allowed the diagnosis of papilloma with parts of conjunctival intraepithelial neoplasia (CIN). Papilloma has been associated with Human Papillomavirus (HPV). The molecular hybridization analysis using PCR revealed that HPV was present in the eye tumor and in the wart, but the viral type was not the same. Treatment of the eye tumor with excision and low temperature cryocoagulation was successful.
Subject(s)
Conjunctival Neoplasms/diagnosis , Eyelid Neoplasms/diagnosis , Papillomaviridae , Papillomavirus Infections/diagnosis , Tumor Virus Infections/diagnosis , Biopsy , Conjunctiva/pathology , Conjunctival Neoplasms/pathology , Eyelid Neoplasms/pathology , Eyelids/pathology , Humans , Male , Middle Aged , Papillomavirus Infections/pathology , Polymerase Chain Reaction , Tumor Virus Infections/pathologyABSTRACT
The positive effect of Naftidrofuryl (Praxilène), a specific serotonine-S2 receptor antagonist, has already been described in the treatment of normal pressure glaucoma. Despite the fact that in POAG intraocular pressure (IOP) is the primary ethiopathogenic mechanism, vascular factors could also influence the progression of the disease, especially in old patients with cardiovascular risk factors. We have studied the effect of Naftidrofuryl versus placebo in a randomised double-blind study on 42 POAG patients. Visual acuity, IOP, Visual field (Octopus program G1), Arterial pressure, Plasma viscosity have been recorded at 0, 12 and 24 weeks. Our results showed no difference between the Naftidrofuryl and the Placebo group for each studied parameter except a decrease of CLV at 12 weeks in the Naftidrofuryl group (p = 0.012). This suggests that Naftidrofuryl is not as effective in POAG as it is in normal tension glaucoma. Other studies with a greater patient - collective and the use of other vasoactive substances will be necessary in the future.
Subject(s)
Glaucoma, Open-Angle/drug therapy , Nafronyl/therapeutic use , Aged , Aged, 80 and over , Double-Blind Method , Female , Humans , Intraocular Pressure/drug effects , Male , Middle Aged , Nafronyl/adverse effects , Prospective Studies , Visual Acuity/drug effects , Visual Fields/drug effectsABSTRACT
Maintaining successful mydriasis is essential during cataract extraction. The use of nonsteroidal anti-inflammatory drugs in order to inhibit trauma induced miosis has been advocated by many authors. Indomethacin 1% has proved his efficacy since many years. Flurbiprofen has been introduced more recently and has been accepted largely because of a better patient comfort. He proved his efficacy against placebo. We conducted a randomized double blind study in order to verify if there is any difference in efficacy between these two drugs. 40 cases were randomly assigned to a pretreatment, not known by the surgeons, with Indomethacin 1% (Indoptic) or Flurbiprofen 0.03% (Ocuflur). Measurements were taken at the beginning of surgery, after nucleous extraction and after irrigationaspiration of lens cortical material. Sodium hyaluronate and epinephrine were not used during this study. After nucleous extraction, the mean pupillary constriction was 1.53 mm in the Indomethacin group and 1.23 mm in the Flurbiprofen group (p greater than 0.1). After aspiration of cortical material, the mean pupillary constriction was 2.27 mm in the Indomethacin group and 2.00 in the Flurbiprofen group (p greater than 0.1). Cumulative results of patients who constricted the pupil more than 2 and 3 mm showed a better result in the Flurbiprofen group. Flurbiprofen has proved in this study his efficacy compared to an other nonsteroidal anti-inflammatory drug in inhibiting trauma induced miosis.
