ABSTRACT
BACKGROUND: Optic neuritis (ON), defined as an inflammatory demyelinating optic neuropathy, is a frequent cause of visual loss owing to optic nerve dysfunction in young or middle-aged patients. ON can be seen in isolation or in association with multiple sclerosis (MS). Highlighting the importance of this association is the fact that approximately 20% of patients with MS will present with ON. METHODS: Review was conducted of the literature and pertinent clinical trials. CONCLUSION: Although the vision prognosis of patients with ON is excellent, with or without the use of corticosteroids, a minority of patients will suffer from significantly poor vision. ON may be the heralding manifestation of MS; the risk stratification for the future development of MS in patients presenting with ON can be determined by the number of white matter lesions on the baseline cerebral magnetic resonance imaging study. To date, 2 randomized, placebo-controlled studies have found that patients with a clinically isolated demyelinating syndrome, such as ON, at risk for MS, may benefit from the early institution of a disease-modifying drug.
Subject(s)
Demyelinating Diseases , Glucocorticoids/therapeutic use , Methylprednisolone/therapeutic use , Optic Neuritis , Prednisolone/therapeutic use , Acute Disease , Adult , Demyelinating Diseases/diagnosis , Demyelinating Diseases/drug therapy , Diagnosis, Differential , Drug Administration Routes , Drug Administration Schedule , Female , Follow-Up Studies , Glucocorticoids/administration & dosage , Humans , Magnetic Resonance Imaging , Methylprednisolone/administration & dosage , Optic Nerve/pathology , Optic Neuritis/diagnosis , Optic Neuritis/drug therapy , Prednisolone/administration & dosage , Visual AcuityABSTRACT
A 71-year-old-man presented with chronic left-sided epiphora and a 5-day history of progressive left orbital swelling that had started with a "bump" on the left side of his nose. Orbital CT revealed left-sided preseptal and postseptal inflammation, along with marked thickening of the left superior ophthalmic vein. Orbital MRI with gadolinium enhancement and fat suppression revealed a low-intensity signal in the left superior ophthalmic vein, consistent with a superior ophthalmic vein thrombosis. There was no cavernous sinus involvement. A diagnosis was made of left-sided dacryocystitis-induced orbital cellulitis and superior ophthalmic vein thrombosis. Treatment consisted of intravenous vancomycin, followed by early dacryocystorhinostomy and postoperative intravenous dexamethasone. Anticoagulation was not used. Within 1 week after surgery, the orbital congestion had dramatically improved. Though rare, isolated superior ophthalmic vein thrombosis can be a harbinger of cavernous sinus thrombosis; therefore, early detection is the key to avoiding cavernous sinus thrombosis.
Subject(s)
Cellulitis/etiology , Dacryocystitis/complications , Orbital Diseases/etiology , Veins , Venous Thrombosis/complications , Aged , Cellulitis/diagnosis , Cellulitis/therapy , Combined Modality Therapy , Dacryocystitis/diagnosis , Dacryocystitis/therapy , Dacryocystorhinostomy , Dexamethasone/therapeutic use , Eye/blood supply , Humans , Magnetic Resonance Imaging , Male , Orbital Diseases/diagnosis , Orbital Diseases/therapy , Tomography, X-Ray Computed , Vancomycin/therapeutic use , Venous Thrombosis/diagnosis , Venous Thrombosis/therapySubject(s)
Facial Injuries/surgery , Surgical Flaps , Suture Techniques/instrumentation , Child, Preschool , Facial Bones/injuries , Facial Muscles/injuries , Facial Muscles/surgery , Female , Fractures, Comminuted/surgery , Humans , Lacerations/surgery , Nose/injuries , Nose/surgery , Plastic Surgery Procedures/instrumentation , Plastic Surgery Procedures/methods , Skull Fractures/surgeryABSTRACT
PURPOSE: To evaluate the incidence of residual diplopia and enophthalmos and the possible risk factors leading to their occurrence in patients who had orbital blowout fracture repair. METHODS: Forty-two patients with pure orbital blowout fracture who had at least 6 months postoperative follow-up were included in the study group. Nineteen (45.2%) patients had orbital floor, two (4.8%) patients had medial orbital wall and 21 (50%) patients had a combination of orbital floor and medial orbital wall fractures. The fracture was reconstructed with porous polyethylene (Medpore) in 22, supramide in 12 and gelatin (Gelfilm) in 8 orbits. Mean postoperative follow-up was 11 months. RESULTS: Preoperatively, 35 patients (83%) had diplopia and 13 patients (30.9%) had enophthalmos greater than 2 mm. Of 35 patients who had preoperative diplopia, only 7 (17%) patients experienced diplopia postoperatively. Diplopia improved 1 to 4 weeks (mean, 3 weeks) following surgery in 28 patients. Timing of surgery and age of the patient were significant for the development of postoperative diplopia (p < 0.05). Sex, location of the blowout fracture and the alloplast material were not found to be significant for the development of postoperative diplopia (p > 0.05). Enophthalmos persisted in three (7%) patients postoperatively. CONCLUSION: Old patients were more likely to have residual postoperative diplopia. Surgical repair of blowout fractures within two weeks of trauma decreases the incidence of residual diplopia.
