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Org Biomol Chem
; 15(46): 9830-9836, 2017 Nov 29.
Article
in English
| MEDLINE
| ID: mdl-29131220
ABSTRACT
Herein, we report a highly regioselective gold-catalyzed formal hydration of propargylic gem-difluorides. Not only does this transformation provide access to versatile fluorinated building blocks that were difficult or hardly possible to access beforehand, but it also represents a rare case of a highly regioselective gold-catalyzed hydroalkoxylation of internal alkynes and puts forward the utility of the difluoromethylene unit as a directing group in catalysis.