Advanced Electroanalysis for Electrosynthesis.

Electrosynthesis is a popular, environmentally friendly substitute for conventional organic methods. It involves using charge transfer to stimulate chemical reactions through the application of a potential or current between two electrodes. In addition to electrode materials and the type of reactor employed, the strategies for controlling potential and current have an impact on the yields, product distribution, and reaction mechanism. In this Review, recent advances related to electroanalysis applied in electrosynthesis were discussed. The first part of this study acts as a guide that emphasizes the foundations of electrosynthesis. These essentials include instrumentation, electrode selection, cell design, and electrosynthesis methodologies. Then, advances in electroanalytical techniques applied in organic, enzymatic, and microbial electrosynthesis are illustrated with specific cases studied in recent literature. To conclude, a discussion of future possibilities that intend to advance the academic and industrial areas is presented.

Extracellular Poly(hydroxybutyrate) Bioplastic Production Using Surface Display Techniques.

Poly(hydroxybutyrate) is a biocompatible, biodegradable polyester synthesized naturally in a variety of microbial species. A greener alternative to petroleum-based plastics and sought after for biomedical applications, poly(hydroxybutyrate) has failed to break through as a leading material in the plastic industry due to its high cost of production. Specifically, the extraction of this material from within bacterial cells requires lysis of cells, which takes time, uses harsh chemicals, and starts the process again with growing new living cells. Recently, surface display of enzymes on bacterial membranes has become an emerging technique for extracellular biocatalysis. In this work, a fusion protein lpp-ompA-phaC was expressed in Escherichia coli to display the enzyme poly(hydroxyalkanoate) synthase on the cell surface. The resulting poly(hydroxybutyrate) product was chemically characterized by nuclear magnetic resonance and infrared spectroscopy. Finally, the extracellular synthesis of the bioplastic granules was demonstrated qualitatively via microscopy and quantitatively by flow cytometry. The results of this work are the first demonstration of extracellular synthesis of poly(hydroxybutyrate), showing promise for continuous and scalable synthesis of materials using surface display.

Examining the Longitudinal Connection Between Adolescent Delinquency and Risky Sexual Behaviors in a Sample of Males and Females.

Adolescence is a time period that is highlighted by widespread involvement in delinquent behaviors. The long-term consequences associated with engaging in such behaviors is not entirely understood. There is some research showing, though, that adolescents who are involved in delinquency are at-risk for also engaging in an assortment of risky sexual behaviors. Whether this association is causal or the result of selection/confounding remains unclear. The current study sought to add to the literature on this topic by examining whether measures of adolescent delinquency predict later-life involvement in risky sexual behaviors (number of sexual partners, number of one-night stands, and being diagnosed with a sexually transmitted infection) in a sample from the United States. To do so, data drawn from the National Longitudinal Study of Adolescent to Adult Health (Add Health) were analyzed (N ranging from 5018 to 5964). The results revealed statistically significant associations between adolescent delinquency and risky sexual behaviors for males and females even after controlling for levels of self-control, exposure to peer substance use, parental socialization, and neighborhood disadvantage. These results suggest that the association between delinquent involvement and risky sexual behaviors is robust and future research should begin to systematically examine the developmental nature of this association.

Bioelectrocatalytic Synthesis: Concepts and Applications.

Bioelectrocatalytic synthesis is the conversion of electrical energy into value-added products using biocatalysts. These methods merge the specificity and selectivity of biocatalysis and energy-related electrocatalysis to address challenges in the sustainable synthesis of pharmaceuticals, commodity chemicals, fuels, feedstocks and fertilizers. However, the specialized experimental setups and domain knowledge for bioelectrocatalysis pose a significant barrier to adoption. This review introduces key concepts of bioelectrosynthetic systems. We provide a tutorial on the methods of biocatalyst utilization, the setup of bioelectrosynthetic cells, and the analytical methods for assessing bioelectrocatalysts. Key applications of bioelectrosynthesis in ammonia production and small-molecule synthesis are outlined for both enzymatic and microbial systems. This review serves as a necessary introduction and resource for the non-specialist interested in bioelectrosynthetic research.

An examination of associations between sexual assault and health problems, depression or suicidal ideation in a large nationally representative cohort of male and female 20-30-year-olds.

BACKGROUND: A long line of research has examined whether being the victim of sexual assault is associated with negative and maladaptive outcomes, but has mainly focused on women and girls. AIMS: To replicate and extend prior research by examining whether various measures of sexual assault are related to physical ill-health, depression and/or suicidal ideation, regardless of sex or age of victim. Our research questions were (1) is sexual assault related to health problems, depression and suicidal ideation and (2) do these associations differ between men and women? METHOD: We analyse data from the National Longitudinal Study of Adolescent to Adult Health (Add Health), a longitudinal study of a US nationally representative sample of nearly 21,000 young people recruited for the first wave of interviews when most of the participants were between ages 12 and 18 years. We used Wave 4 data, collected for participants who were in their 20s and 30s, on experience of both physical sexual assault and non-physical sexual assault and mental state, allowing for some characteristics measured in Wave 1. Allowing for missing data, sample sizes were between 6868 and 10,489 for the women and 6024 and 10,263 for the men. RESULTS: Statistically significant associations were revealed between the physical and non-physical measures of sexual assault and the health problems scale, the depression scale and the measure of suicidal ideation. These associations remained statistically significant even after controlling for key covariates measured at Wave 1, including exposure to delinquent peers, poverty and demographic characteristics. CONCLUSIONS: Sexual assault at some time and of whatever kind, although more commonly reported by women than men, is similarly associated with serious physical and mental health problems during their 20s and 30s. More sequencing detail is required for better prevention of harms.

Involvement in Crime and Delinquency and the Development of Technological and Computer Skills: A Longitudinal Analysis.

A body of research has revealed that involvement in crime and delinquency is associated with a wide number of social, economic, and health consequences. The current study built off this knowledge base and examined whether measures of adolescent violent delinquency and contact with the criminal justice system were related to the access of basic, and experience with, technology, and computers. To do so, longitudinal data drawn from the National Longitudinal Study of Adolescent to Adult Health (Add Health) were analyzed. The results revealed that self-reported violent delinquency in adolescence was associated with a decreased probability of owning a computer and having an email account 10 to 12 years into the future. Additionally, measures of contact with the criminal justice system, low self-control, delinquent peers, and governmental public assistance were also associated with the probability of owning a computer and having an email account.

Adolescent Delinquency and Adulthood Economic Disadvantage and Job Benefits: Results From a Longitudinal Sample of Males and Females.

There is a long history of examining the connection between crime and delinquency and economic well-being and employment quality. Despite this vast literature, there still remains unanswered questions surrounding these associations, including whether the timing of adolescent delinquency is associated with adulthood economic disadvantage and job quality, whether different types of adolescent delinquency maintain differential associations with measures of economic disadvantage and employment quality in adulthood, and whether any associations between delinquency and economics/employment are invariant between males and females. The current study sought to address these issues by exploring the associations between adolescent involvement in nonviolent and violent delinquency (measured at two times in adolescence) and adulthood economic disadvantage and job quality. To do so, data drawn from the National Longitudinal Study of Adolescent to Adult Health were analyzed. The results revealed consistently null associations between the measures of adolescent delinquency and economic disadvantage and job quality for males. For females, however, the results were consistently significant, indicating that females who self-reported greater involvement in delinquency were more likely to be economically disadvantaged as adults and to have lower quality jobs. These results indicate that the associations between delinquency and economic disadvantage and job benefits differs between males and females, with females, in comparison with males, paying a significantly greater toll for engaging in acts of violent and nonviolent delinquency.

Social Adversity Reduces Polygenic Score Expressivity for General Cognitive Ability, but Not Height.

It has been hypothesized that even 'perfect' polygenic scores (PGSs) composed of only causal variants may not be fully portable between different social groups owing to gene-by-environment interactions modifying the expression of relevant variants. The impacts of such interactions involving two forms of social adversity (low socioeconomic status [SES] and discrimination) are examined in relation to the expressivity of a PGS for educational attainment composed of putatively causal variants in a large, representatively sampled and genotyped cohort of US children. A relatively small-magnitude Scarr-Rowe effect is present (SES × PGSEDU predicting General Cognitive Ability [GCA]; sR = .02, 95% CI [.00, .04]), as is a distinct discrimination × PGSEDU interaction predicting GCA (sR = -.02, 95% CI [-.05, 00]). Both are independent of the confounding main effects of 10 ancestral principal components, PGSEDU, SES, discrimination and interactions among these factors. No sex differences were found. These interactions were examined in relation to phenotypic and genotypic data on height, a prospectively more socially neutral trait. They were absent in both cases. The discrimination × PGSEDU interaction is a co-moderator of the differences posited in modern versions of Spearman's hypothesis (along with shared environmentality), lending support to certain environmental explanations of those differences. Behavior-genetic analysis of self-reported discrimination indicates that it is nonsignificantly heritable (h2 = .027, 95% CI [-.05, .10]), meaning that it is not merely proxying some underlying source of heritable phenotypic variability. This suggests that experiences of discrimination might stem instead from the action of purely social forces.

Does Self-control Predict Crime, Delinquency, and Victimization in Immigrants? A Longitudinal Analysis.

Gottfredson and Hirschi's theory of low self-control has generated a considerable amount of research and the results of these studies have shown that low levels of self-control are consistently associated with involvement in antisocial outcomes. Despite the empirical support for this theory, there still remain areas of it that need to be more fully evaluated. Once such area is whether self-control is associated with antisocial outcomes in samples of immigrants. The current study sought to address this gap in the literature. To do so, data drawn from the National Longitudinal Study of Adolescent to Adult Health (Add Health) were analyzed. The results of the statistical models revealed that low levels of self-control were associated with increases in self-reported delinquency, being arrested, being convicted of a crime, being sentenced to probation, being incarcerated, and being victimized. Taken together, the results of this study show that self-control is a robust predictor of antisocial outcomes among immigrants. We conclude by identifying limitations of the current study and directions for future research.

Association of Environmental Risk Factors and Personality Traits With Risky Driving Behaviors in a Sample of Young Adults From Saudi Arabia.

Road traffic accidents represent a serious problem in the Kingdom of Saudi Arabia (KSA), with rates of such accidents far exceeding the rates in developed nations. Even so, there remains relatively little knowledge regarding the driving behaviors among Saudi Arabians. The current study sought to address this gap in the literature by examining the environmental and trait-based contributors to risky driving behaviors among male and female drivers in the KSA. To do so, a sample of college students from a large university in the KSA was analyzed. The results revealed that delinquent peers, low levels of self-control, and higher levels of driving anger were associated with involvement in risky driving behaviors for both male and female drivers. Understanding the interconnections among peers, self-control, anger, and risky driving behaviors may provide some insight into how to reduce risky driving behaviors. Focusing on ways to reduce exposure to risk factors for risky driving behaviors may be one strategy for reducing these types of driving behaviors.

A genetically-controlled, cross-lagged study of the association between friends' deviance and participants' delinquency during adolescence: A replication.

The goal of the present study was to replicate Burt et al. (2009) and Hou et al. (2013) findings by determining the contribution of peers' deviance to changes in participants' (monozygotic [MZ] twins') self-reported delinquency from mid- to late adolescence while controlling for possible gene-environment correlations (rGE) through the use of the cotwin method in the context of a cross-lagged design. Two separate samples were used to this purpose. The first sample included 289 MZ-twin pairs (48.42% female; 65.5% of European descent, 21.7% of African descent, 12.8% other; average age at first assessment = 16.20 years) and relied on perceived measures of peer deviance, as in the two original studies. The second sample comprised 181 MZ-twin pairs (50.67% female; 84% of European descent, 3% of African descent, 2% of Asian descent, 2% Native North Americans, and 9% unspecified; average age at first assessment = 13.05 years) and used direct measures to assess peers' deviance. Participants in the first sample were part of a large representative sample of American adolescents, whereas the second sample included families with twins born in a large Canadian city. Results showed that within-pair differences in self-reported delinquency were stable from midadolescence to late adolescence in both samples. As in Burt et al. (2009) and Hou et al. (2013) within-pair differences in peer deviance did not predict changes in within-pair differences in self-reported delinquency in both samples (i.e., no socialization effect). In contrast to Burt et al. (2009) and Hou et al. (2013), however, we found no predictive link from twins' self-reported delinquency to peers' deviance (i.e., no selection effect). Finally, as in Burt et al. (2009) we found that peers' deviance was stable from middle to late adolescence and that peers' deviance and participants' delinquency were cross-sectionally correlated in the first sample, but not in the second sample. These results are interpreted in the context of the ongoing debate in regard to peers' socialization vs selection effects. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Materials Approaches for Improving Electrochemical Sensor Performance.

Electrochemical sensors have emerged as important diagnostic tools in recent years, due to their simplicity and ease of use. Compared to instrumental analysis methods that use complicated experimental and data analysis techniques─such as mass spectrometry, nuclear magnetic resonance (NMR), spectrophotometric methods, and chromatography─electrochemical sensors show promise for use in a wide range of real-time and in situ applications such as pharmaceutical testing, environmental monitoring, and medical diagnostics. In order to identify analytes in complex and/or biological samples, materials used for both the electrode materials and the chemically selective layer have been evolving throughout the years for optimizing the analytical performance of electrochemical sensors to increase sensitivity, selectivity and linear range. In this Perspective, attention will be focused on different types of materials that have been used for electrochemical sensing, including new combinations of well-studied materials as well as novel strategies to enhance the performance of sensing devices. The Perspective will also discuss existing challenges in the field and future strategies for addressing those challenges.

Examining the potential link between child maltreatment and callous-unemotional traits in children and adolescents: A multilevel analysis.

BACKGROUND: There is a great deal of research indicating that callous-unemotional traits in childhood are among the strongest predictors of adult psychopathy and psychopathic traits. As a result, there has been a recent surge of studies examining potential risk factors that may be related to the development of callous-unemotional traits. OBJECTIVE: The current study sought to extend prior research examining potential risk factors for the development of callous-unemotional traits by estimating the extent to which child maltreatment related to callous-unemotional traits in children and adolescents. PARTICIPANTS: To do so, the study uses a longitudinal sample of 4579 male and female youths drawn from the National Survey of Child and Adolescent Well-Being (NSCAW I) across four waves of data. Data collection ran from November 1999 to December 2006. METHODS: A series of multilevel random-effects models were estimated in order to examine the association between child maltreatment and callous-unemotional traits. RESULTS: The results of the analyses revealed a significant association between child maltreatment and callous-unemotional traits across all the models. Additionally, our models demonstrated that the association between child maltreatment and callous-unemotional traits may be dependent upon the biological sex of the individual with child maltreatment having a stronger effect on males than females (ß = 0.15*). CONCLUSIONS: Overall, our analyses lend support to prior research examining child maltreatment as a risk factor for the development of callous-unemotional traits in youth. We conclude by discussing the implications of our study and considerations for future research.

Function of the pseudo phosphotransfer proteins has diverged between rice and Arabidopsis.

The phytohormone cytokinin plays a significant role in nearly all aspects of plant growth and development. Cytokinin signaling has primarily been studied in the dicot model Arabidopsis, with relatively little work done in monocots, which include rice (Oryza sativa) and other cereals of agronomic importance. The cytokinin signaling pathway is a phosphorelay comprised of the histidine kinase receptors, the authentic histidine phosphotransfer proteins (AHPs) and type-B response regulators (RRs). Two negative regulators of cytokinin signaling have been identified: the type-A RRs, which are cytokinin primary response genes, and the pseudo histidine phosphotransfer proteins (PHPs), which lack the His residue required for phosphorelay. Here, we describe the role of the rice PHP genes. Phylogenic analysis indicates that the PHPs are generally first found in the genomes of gymnosperms and that they arose independently in monocots and dicots. Consistent with this, the three rice PHPs fail to complement an Arabidopsis php mutant (aphp1/ahp6). Disruption of the three rice PHPs results in a molecular phenotype consistent with these elements acting as negative regulators of cytokinin signaling, including the induction of a number of type-A RR and cytokinin oxidase genes. The triple php mutant affects multiple aspects of rice growth and development, including shoot morphology, panicle architecture, and seed fill. In contrast to Arabidopsis, disruption of the rice PHPs does not affect root vascular patterning, suggesting that while many aspects of key signaling networks are conserved between monocots and dicots, the roles of at least some cytokinin signaling elements are distinct.

Neighborhood Exposure to Violence and Delinquency in the Kingdom of Saudi Arabia: A Partial Test of Social Structure and Social Learning Theory.

The social structure and social learning (SSSL) model for crime and deviance has received an impressive amount of empirical support in the United States and other Western industrialized countries. Comparatively, less research, however, has examined whether the SSSL model offers a viable framework for explaining variation in delinquent behavior in other geographic contexts, particularly, countries that place a stronger emphasis on social control stemming from both formal and religious sources. The current study addresses this void in the literature by examining a sample of youth from Saudi Arabia, a Middle Eastern country that enforces Sharia (a set of laws based in Islamic tradition) and strict gender roles. The association between neighborhood exposure to violence and risk for violent and nonviolent delinquent behavior was examined using structural equation models. Subsequent models were aimed at more closely examining the mediating role of delinquent peer association between neighborhood exposure to violence and violent and nonviolent delinquent behavior. Results indicate that males exposed to neighborhood violence are more likely to engage in violent and nonviolent delinquent behavior, whereas females are more likely to engage in violent, but not nonviolent, delinquent behavior. In line with the SSSL model, delinquent peer association fully mediates the direct effect of neighborhood exposure to violence on delinquent behavior in both males and females. Findings from the current study suggest that the SSSL model may provide a useful framework for explaining individual differences in delinquent behavior in Saudi Arabia.

Examining the Potential Association Between Immigration and Criminal Involvement Using a Nationally Representative and Longitudinal Sample of Youth.

There has been a great deal of debate regarding the association between immigration and criminal involvement. Against this backdrop, this study sought to make an incremental increase to the literature by examining the nexus between immigration and crime. To do so, data were drawn from the National Longitudinal Study of Adolescent to Adult Health (N = 7,622-8,334). The results of the multivariate regression models revealed no evidence that immigrants, in comparison with U.S. citizens, self-reported more involvement in nonviolent delinquency or violent delinquency. Where statistically significant effects did emerge, U.S. citizens reported greater involvement in these acts. Moreover, the analyses also did not provide any evidence that immigrants were more likely than U.S. citizens to report being arrested, pleading guilty, being sentenced to probation, or being incarcerated. Once again, U.S. citizens were significantly more likely to have contact with the criminal justice system when compared with immigrants. These results suggest that the potential link between immigration and crime is likely complex and is not a straightforward association. We conclude by discussing some of the implications of the findings and directions for future research.

Psychopathic Personality Traits and the Risk for Personal Victimization.

Previous research links psychopathic traits with involvement in criminal behavior and numerous negative life outcomes. To date, however, a relatively limited amount of research has examined whether psychopathic traits confer an increased risk of victimization. This area of research is of interest as some scholars contend that psychopathic traits may confer several advantages for life outcomes including outcomes related to criminal conduct. As a result, psychopaths may be at a decreased risk of victimization. On the contrary, research examining the victim-offender overlap indicates that as psychopaths are likely to be involved in criminal behavior they would be more likely to be victimized. This article addresses this gap in the literature by examining whether psychopathic personality traits are associated with odds of victimization in a large nationally representative sample of Americans from adolescence to adulthood. Specifically, our study employs logistic regression and Poisson regression to test associations between psychopathic personality traits and victimization in data drawn from the National Longitudinal Study of Adolescent to Adult Health (Add Health). Our findings reveal that psychopathic personality traits are positively associated with odds of victimization in adolescence and adulthood. In addition, our findings indicate that psychopathic personality traits interact with criminal involvement to predict odds of victimization. The findings of our study have implications for the literatures concerning successful psychopathy and the victim-offender overlap.

Low Self-Control, Victimization, and Financial Hardship: Does Low Self-Control Moderate the Relationship Between Strain and Criminal Involvement?

General strain theory has been widely supported by empirical research. Research concerning possible individual-level moderators of the effects of strain, however, has yielded considerably mixed results. The current study addresses this gap in the literature by examining whether levels of self-control moderate the relationship between strain and criminal involvement in a large nationally representative sample. Our findings reveal that strain and levels of self-control have both additive and interactive effects on criminal involvement. To illustrate, respondents who were exposed to higher levels of strain reported more criminal involvement than respondents exposed to lower levels of strain. Similarly, lower levels of self-control were associated with higher levels of criminal involvement. In addition, levels of self-control were found to moderate the association between experiencing strain and two of the criminal involvement measures. Furthermore, the results suggest that the relationships among strain, self-control, and criminal involvement may vary across gender and forms of strain.

Maternal Depression and Child and Adolescent Problem Behaviors: a Propensity Score Matching Approach.

Prior studies have consistently revealed that maternal depression is significantly associated with children exhibiting higher levels of internalizing problem behaviors and externalizing problem behaviors. However, there is reason to believe that prior research may have suffered from model misspecification and confounding that biased the conclusions drawn from these studies. We use this possibility as the foundation for our analyses that examine the potential association between maternal depression and child internalizing and externalizing problem behaviors while addressing the methodological limitations of previous research. To do so, we analyzed data from the National Survey of Child and Adolescent Well-Being and used propensity score matching. The analyses revealed significant differences between depressed and non-depressed mothers that, once accounted for, significantly impacted the revealed associations between maternal depression and child internalizing and externalizing problem behaviors. Although the significant relationship with child internalizing problem behaviors remained in all of the cross-sectional and longitudinal models post-matching, once the mothers were properly matched, the significant relationship between maternal depression and child externalizing problem behaviors disappeared at Wave 3. We conclude by discussing the implications and limitations of our study as well as considerations for future research.

Fundamentals, Applications, and Future Directions of Bioelectrocatalysis.

Bioelectrocatalysis is an interdisciplinary research field combining biocatalysis and electrocatalysis via the utilization of materials derived from biological systems as catalysts to catalyze the redox reactions occurring at an electrode. Bioelectrocatalysis synergistically couples the merits of both biocatalysis and electrocatalysis. The advantages of biocatalysis include high activity, high selectivity, wide substrate scope, and mild reaction conditions. The advantages of electrocatalysis include the possible utilization of renewable electricity as an electron source and high energy conversion efficiency. These properties are integrated to achieve selective biosensing, efficient energy conversion, and the production of diverse products. This review seeks to systematically and comprehensively detail the fundamentals, analyze the existing problems, summarize the development status and applications, and look toward the future development directions of bioelectrocatalysis. First, the structure, function, and modification of bioelectrocatalysts are discussed. Second, the essentials of bioelectrocatalytic systems, including electron transfer mechanisms, electrode materials, and reaction medium, are described. Third, the application of bioelectrocatalysis in the fields of biosensors, fuel cells, solar cells, catalytic mechanism studies, and bioelectrosyntheses of high-value chemicals are systematically summarized. Finally, future developments and a perspective on bioelectrocatalysis are suggested.