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1.
Anticancer Res ; 22(2B): 1347-52, 2002.
Article in English | MEDLINE | ID: mdl-12168949

ABSTRACT

Polymorphous low-grade adenocarcinoma (PLGA) is a distinctive salivary gland neoplasm with a predilection for intraoral sites. Histological and immunohistochemical analyses were used to study a case involving the minor salivary glands of the buccal mucosa in a 68-year-old woman. Histologically, the tumor was characterized by unenca-psulated, progressing and focally-infiltrative borders and showed variable growth patterns including solid, tubular, microcystic and cribriform; papillary and papillary-cystic areas of more than focal extent were present. Cytologically the neoplasm was composed of uniform, round to cuboidal cells with bland, round to oval nuclei. Immunohistochemical analysis showed that the tumor cells were positive for cytokeratin, S-100 protein, vimentin, focally-positive for EMA and actin and negative for CEA. The significance of the papillary component and the possible relationship to other salivary gland tumors is discussed.


Subject(s)
Adenocarcinoma/pathology , Salivary Gland Neoplasms/pathology , Adenocarcinoma/metabolism , Aged , Female , Humans , Immunohistochemistry , Mouth Mucosa/pathology , Salivary Gland Neoplasms/metabolism , Salivary Glands, Minor/pathology
2.
Cardiovasc Pathol ; 10(1): 43-8, 2001.
Article in English | MEDLINE | ID: mdl-11343995

ABSTRACT

We report an unusual case of "arrhythmic" sudden cardiac death in a 3-year-old child who died of ischemic myocardial lesions as a result of intimal fibroplasia of the coronary arteries. Also affected were the aorta and its major branches, whereas renal and mesenteric arteries, celiac trunk, and systemic veins were normal. Histopathologic examination showed severe concentric thickening of intima because of a proliferation of spindle-shaped cells (mesenchymal cells) set in an abundant extracellular matrix. In some vascular segments the intima was densely fibrotic and hyalinized. No significant inflammation, foam cells, cholesterol clefts, or other evidence of atheroma were present. The intimal lesions did not involve the media and/or the adventitia. Immunohistochemical staining of intima showed the proliferating mesenchimal cells to be myofibroblastic. Reactions for vimentin and smooth muscle actin were positive, while those for desmin, myosin, CD34, and Factor VIII were negative.


Subject(s)
Aorta/pathology , Arrhythmias, Cardiac/pathology , Coronary Vessels/pathology , Death, Sudden, Cardiac/pathology , Fibromuscular Dysplasia/pathology , Tunica Intima/pathology , Actins/analysis , Arrhythmias, Cardiac/complications , Child, Preschool , Death, Sudden, Cardiac/etiology , Fibromuscular Dysplasia/complications , Heart Ventricles/pathology , Humans , Immunohistochemistry , Male , Myocardium/pathology , Polyps/pathology , Tunica Intima/chemistry , Vimentin/analysis
3.
Hum Pathol ; 32(12): 1407-9, 2001 Dec.
Article in English | MEDLINE | ID: mdl-11774178

ABSTRACT

This article describe's a case of atypical Kawasaki disease (AKD) with lack of typical clinical signs and rapid fatal course in a 2-month-old infant, who 1 week before hospitalization demonstrated rhinitis, coughing without fever, and later conjunctival hyperemia and allergic exanthema on chest and arms. On admittance, labwork highlighted the following: leukocytosis, thrombocytosis, elevated sedimentation rate, and positive C-reactive protein. General conditions remained mediocre for 7 days until sudden death occurred. The autopsy confirmed death caused by cardiac tamponade caused by a ruptured inflammated aneurysm of the left anterior descending coronary artery. We believe that the currently accepted clinical diagnostics criteria for KD in infants 2 years of age or younger can cause missed in vita diagnosis of AKD. For such, any typical clinical sign of KD whenever associated with thrombocytosis and elevated indices of phlogosis, should led to suspicion of KD and permit cardiovascular examination, and thus early treatment.


Subject(s)
Coronary Aneurysm/complications , Mucocutaneous Lymph Node Syndrome/complications , Sudden Infant Death/etiology , Acute Disease , Coronary Aneurysm/pathology , Fatal Outcome , Humans , Infant , Male , Mucocutaneous Lymph Node Syndrome/pathology , Sudden Infant Death/pathology
4.
Pathologica ; 87(6): 666-71, 1995 Dec.
Article in Italian | MEDLINE | ID: mdl-8927428

ABSTRACT

In this report the authors describe a rare case of pulmonary/renal syndrome like-Goodpasture's disease characterized by a necrotizing acute capillaritis in the lung, kidney, liver, spleen and heart. In the heart the capillaritis was associated with a contiguous acute ischemic lesion. The clinical and pathologic findings of the case suggest that the presence of vasculitis should not exclude a diagnosis of Goodpasture's Syndrome and that the multisystemic capillaritis would demonstrate the organ-non-specificity of anti-glomerular/alveolar basement membrane antibody.


Subject(s)
Anti-Glomerular Basement Membrane Disease/complications , Autoimmune Diseases/complications , Kidney/blood supply , Lung/blood supply , Vasculitis/complications , Acute Disease , Adolescent , Anti-Glomerular Basement Membrane Disease/diagnosis , Anti-Glomerular Basement Membrane Disease/immunology , Anti-Glomerular Basement Membrane Disease/pathology , Autoimmune Diseases/diagnosis , Autoimmune Diseases/immunology , Autoimmune Diseases/pathology , Capillaries/immunology , Capillaries/pathology , Fatal Outcome , Humans , Kidney/pathology , Lung/pathology , Male , Necrosis , Vasculitis/diagnosis , Vasculitis/immunology , Vasculitis/pathology
5.
Pathologica ; 87(6): 672-6, 1995 Dec.
Article in Italian | MEDLINE | ID: mdl-8927429

ABSTRACT

The case refers to a term-fetus, small-for-date, with polydramnios, idiopathic hypereosinophilic syndrome and eosinophilic vasculitis of large, medium and small-size pulmonary arteries. The pulmonary arteritis was the only lesion observed in the fetus.


Subject(s)
Hypereosinophilic Syndrome/congenital , Polyarteritis Nodosa/congenital , Pulmonary Artery/pathology , Adult , Fatal Outcome , Female , Humans , Infant, Newborn , Infant, Small for Gestational Age , Male , Polyarteritis Nodosa/pathology , Pregnancy , Pregnancy Complications
6.
Pathologica ; 87(6): 677-81, 1995 Dec.
Article in Italian | MEDLINE | ID: mdl-8927430

ABSTRACT

The Authors describe two cases of giant cell arteritis in male and elderly patients 72 and 82 years old. In both cases the early symptoms and signs of disease (headache, fever, weight loss and sedimentation rate raised) were associated to classical histology of temporal arteritis (granulomatous inflammation with giant cells). In case 1 there was impaired vision, while in case 2 coexisted polymialgia rheumatica (pain and stiffness in the muscles of the neck, back and proximal portions of the limbs).


Subject(s)
Giant Cell Arteritis/pathology , Temporal Arteries/pathology , Aged , Aged, 80 and over , Giant Cell Arteritis/etiology , Humans , Male , Polymyalgia Rheumatica/complications , Polymyalgia Rheumatica/pathology
7.
Histol Histopathol ; 10(1): 55-60, 1995 Jan.
Article in English | MEDLINE | ID: mdl-7756744

ABSTRACT

Giant cell tumor (GCT) of the ovary is a rare condition, found almost invariably in the context of a mucinous tumor and presenting a microscopic picture indistinguishable from GCT of bone. We describe a case of GCT in the wall of a serous cyst of the ovary. An immunohistochemical study was performed using a panel of antibodies to epithelial, mesenchymal and leukocyte antigens. Mononuclear and giant tumor cells were positive for vimentin; CD 68 and LCA were found only in giant cells whereas actin was only found in mononuclear tumor cells. The immunophenotypic profile of the stromal cells of the residual ovary was identical to that of mononuclear tumor cells. The presented data suggest that GCT of the ovary is probably a non-neoplastic lesion of the mesenchymal stromal cells that react against substances of the associated tumor or cyst.


Subject(s)
Giant Cell Tumors/metabolism , Giant Cell Tumors/pathology , Ovarian Neoplasms/metabolism , Ovarian Neoplasms/pathology , Actins/metabolism , Adult , Antigens, CD/metabolism , Antigens, Differentiation, Myelomonocytic/metabolism , Female , Giant Cell Tumors/immunology , Humans , Immunohistochemistry , Leukocyte Common Antigens/metabolism , Ovarian Cysts/immunology , Ovarian Cysts/metabolism , Ovarian Cysts/pathology , Ovarian Neoplasms/immunology , Vimentin/metabolism
8.
G Ital Cardiol ; 23(10): 995-1003, 1993 Oct.
Article in Italian | MEDLINE | ID: mdl-8174867

ABSTRACT

Anomalous origin of the right coronary artery from the left sinus of Valsalva is a rare congenital anomaly classified as a "minor" anomaly of no clinical importance. Recently, manifestations of myocardial ischemia (angina pectoris, myocardial infarction, nonfatal ventricular fibrillation, sudden death) have been described in patients with this anomaly in the absence of atherosclerosis or other. Sudden death occurs frequently in symptomatic patients and rarely in asymptomatic patients (sudden unexpected death). In this study we report two cases of juvenile sudden death observed in asymptomatic patients with anomalous origin of the right coronary artery from the left sinus of Valsalva. In both cases the sudden death was exertion-related. In case 1 the coronary anomaly was the cause of death, since it was the only significant anatomic abnormality at necropsy; the microscopic findings revealed ischemic lesions only in the myocardium supplied by the anomalous right coronary artery. In case 2 the coronary anomaly was connected to other cardiac and non cardiac diseases (lymphocytic active myocarditis, chronic portitis, encephalitis, medullary adrenalitis). Since these morphologic lesions were extremely slight and there was no adrenal catecholamine damage in the myocardium, we consider negligible their possible role in determining death, which in this case was induced by the congenital coronary anomaly. The cardiac microscopic findings, also in this case, revealed ischemic lesions in the myocardium supplied by the anomalous right coronary artery.(ABSTRACT TRUNCATED AT 250 WORDS)


Subject(s)
Abnormalities, Multiple , Coronary Vessel Anomalies/complications , Death, Sudden/etiology , Sinus of Valsalva/abnormalities , Abnormalities, Multiple/pathology , Adolescent , Adult , Coronary Vessel Anomalies/pathology , Humans , Male , Sinus of Valsalva/pathology
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