ABSTRACT
Infection with Equid Herpesvirus type 1 (EHV-1) leads to respiratory disease, abortion, and neurological disorders in horses. Molecular epidemiology studies have demonstrated that a single nucleotide polymorphism (A(2254)/G(2254)) in the genome region of the open reading frame 30 (ORF30), which results in an amino acid variation (N(752)/D(752)) of the EHV-1 DNA polymerase, is significantly associated with the neuropathogenic potential of naturally occurring strains. In order to estimate the prevalence of the EHV-1 neuropathogenic genotype in our country, we analyzed the ORF30 genome region of Argentinean EHV-1 isolates. The study was carried out by real time allelic discrimination PCR in 90 equine EHV-1-positive samples, being 89 from 54 cases of abortion outbreaks (two of which were in association with neurological disease) and one from the respiratory tract of a healthy horse in training. Our results indicate that 7% (4/54) of the abortion outbreaks studied were induced by the neuropathogenic (G(2254)) genotype of EHV-1 and 50% (2/4) of them were associated with simultaneous neurological disease. This information emphasizes the necessity to extreme the hygienic and preventive measures to diminish EHV-1 infections and consequently reduce the risk of epizootic neurological disease as has been recently observed in other countries.
Subject(s)
Herpesviridae Infections/veterinary , Herpesvirus 1, Equid/genetics , Horse Diseases/virology , Animals , Argentina/epidemiology , DNA, Viral/genetics , Disease Outbreaks/veterinary , Female , Genotype , Herpesviridae Infections/epidemiology , Herpesviridae Infections/virology , Herpesvirus 1, Equid/isolation & purification , Horse Diseases/epidemiology , Horses , Mice , Polymerase Chain Reaction/veterinary , PregnancyABSTRACT
Presentamos un caso de atresia ileal distal diagnosticada por ultrasonidos en la semana 32 de gestación en un control prenatal ecográfico rutinario (figs. 1, 2 y 3). El parto aconteció a las 35 semanas de embarazo mediante cesárea, y se obtuvo un recién nacido de 1900g. de peso, y fue sometido a corrección quirúrgica de su defecto congénito a las 24h, con evolución favorable (AU)
We present a case of atresia of the distal ileum, diagnosed during routine ultrasound in the 32nd week of gestation (figures 1, 2 and 3). A 1900g infant was delivered by caesarean section at 35 weeks, and had successful correction of the atresia twenty-four hours later (AU)
Subject(s)
Female , Pregnancy , Infant, Newborn , Adult , Humans , Intestinal Atresia , Ileal Diseases , Ultrasonography, Prenatal/methodsABSTRACT
Estudio retrospectivo de 9 casos de pacientes con hipertensión en el contexto de una preeclampsia grave, tratadas con clorhidrato de urapidil. Analizamos una serie de variables: edad, semanas de gestación, dosis y número de ellas empleadas, tiempo transcurrido en controlar la presión arterial, efectos adversos maternofetales y test de Apgar al nacimiento. Los resultados demuestran la eficacia de dicho fármaco en el control de la hipertensión grave inducida por embarazo; normalizó en un tiempo relativamente corto tanto la presión arterial sistólica como la diastólica (11,6 ñ 7,50 min) y con dosis bajas (20,3 ñ 11,13) en 7 casos; sólo en un caso se requirieron tiempo y dosis mayores (40 min y 70 mg), y en otra gestante de 28 semanas no se pudo controlar y se tuvo que finalizar la gestación mediante cesárea. En cuanto a las reacciones adversas, tanto maternas como neonatales, a diferencia de los antihipertensivos habituales (hidralacina, labetalol o nifedipina), fueron irrelevantes (AU)
