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Wild-Type Yellow Fever Virus RNA in Cerebrospinal Fluid of Child.

Marinho, Paula E S; Alvarenga, Pedro P M; Crispim, Ana P C; Candiani, Talitah M S; Alvarenga, Alice M; Bechler, Isabela M; Alves, Pedro A; Dornas, Fabio P; de Oliveira, Danilo B; Bentes, Aline A; Christo, Paulo P; Kroon, Erna G.

Emerg Infect Dis ; 25(8): 1567-1570, 2019 08.

Article in English | MEDLINE | ID: mdl-31310221

ABSTRACT

We report a 3-year-old child who was hospitalized because of severe manifestations of the central nervous system. The child died after 6 days of hospitalization. Analysis of postmortem cerebrospinal fluid showed the presence of yellow fever virus RNA. Nucleotide sequencing confirmed that the virus was wild-type yellow fever virus.

Subject(s)

RNA, Viral/genetics , Yellow Fever/cerebrospinal fluid , Yellow Fever/virology , Yellow fever virus/genetics , Antiviral Agents/pharmacology , Antiviral Agents/therapeutic use , Autopsy , Biomarkers , Brazil , Child, Preschool , Disease Progression , Fatal Outcome , Female , Humans , Phylogeny , Sequence Analysis, DNA , Symptom Assessment , Tomography, X-Ray Computed , Yellow Fever/diagnosis , Yellow Fever/drug therapy , Yellow fever virus/classification , Yellow fever virus/isolation & purification

ABSTRACT

Subject(s)

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