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1.
Appl Opt ; 62(1): 91-101, 2023 Jan 01.
Article in English | MEDLINE | ID: mdl-36606856

ABSTRACT

The tool influence function (TIF) during sub-aperture belt-on-wheel polishing has been evaluated as a function of various process conditions (belt use/wear, dwell time, displacement, belt velocity, and wheel modulus and diameter) on fused silica glass workpieces using C e O 2 polishing media. TIF spots are circular or elliptical in shape with a largely flat bottom character. The volumetric removal rate varies significantly with belt use (or wear), stabilizing after ∼15m i n of use. A modified Preston model, where the pressure dependence is adjusted using a different scaling of the wheel modulus (E w0.5), largely predicts the volumetric removal rate over the range of process conditions evaluated. The relatively high volumetric removal rate of 30-60m m 3/h using a fixed C e O 2-in-resin-host belt offers a rapid, and hence, more economical, initial polish of aspheric and freeform optics.

2.
Abdom Imaging ; 28(6): 808-14, 2003.
Article in English | MEDLINE | ID: mdl-14753595

ABSTRACT

BACKGROUND: Tyrosine kinase inhibitor (Gleevec or STI-571) must be considered the treatment of choice for metastatic gastrointestinal stromal tumors (GISTs). The purpose of this article is to address and illustrate a long-term follow-up of computed tomographic (CT) radiologic findings in patients with metastases from GIST after Gleevec treatment. METHODS: We performed a retrospective review of seven patients (four male, three female) with unresectable metastases from GIST who were treated with STI-571 in a 1-year period. Patients were followed every 2-4 months by contrast-enhanced CT for up to 12 months. The size and attenuation of hepatic and peritoneal metastases on CT were measured and correlated. RESULTS: Hepatic metastases from GISTs showed significant decreased attenuation from a mean of 60 HU to a mean of 32 HU (p < 0.01) in the first 2 months and continued decreasing attenuation to 23 HU at the 12-month follow-up. These metastases superficially resembled simple cysts. Most metastases became smaller, with more defined borders, after treatment. Histologic examination in a resected specimen revealed hepatic cyst with no residual tumor cells, regression of omental lesions, and extensive necrosis. CONCLUSIONS: CT findings of unresectable hepatic and peritoneal metastases from GIST displayed decreasing, near cystic attenuation and size as an effective regression in response to STI-571 treatment.


Subject(s)
Antineoplastic Agents/therapeutic use , Gastrointestinal Neoplasms/pathology , Liver Neoplasms/drug therapy , Liver Neoplasms/secondary , Peritoneal Neoplasms/drug therapy , Peritoneal Neoplasms/secondary , Piperazines/therapeutic use , Protein-Tyrosine Kinases/antagonists & inhibitors , Pyrimidines/therapeutic use , Adult , Aged , Benzamides , Female , Follow-Up Studies , Humans , Imatinib Mesylate , Male , Middle Aged , Retrospective Studies , Stromal Cells , Time Factors
3.
Abdom Imaging ; 26(4): 406-10, 2001.
Article in English | MEDLINE | ID: mdl-11441554

ABSTRACT

Disseminated peritoneal adenomucinosis (DPAM) is a relatively rare cause of pseudomyxoma peritonei, marked by peritoneal lesions with abundant extracellular mucin and little cytologic atypia among exfoliated tumor cells, and usually associated with appendiceal adenomas. Peritoneal mucinous carcinomatosis (PMCA) also causes diffuse peritoneal tumor but is marked by neoplastic mucinous epithelium with cytologic features of carcinoma and associated with appendiceal, colon, gastric, or small bowel carcinoma. Compared with PMCA, DPAM has a different distribution of disease and a significantly better prognosis. DPAM is characterized by the lack of lymph node involvement, with primarily superficial peritoneal involvement, and a relatively benign, relapsing course over many years. Dominant primary masses may not be evident in DPAM. Despite considerable overlap in the two main causes of pseudomyxoma peritonei, there are features of the two that may help differentiate between them. We present the computed tomographic appearance of DPAM in a series of seven cases and emphasize characteristics of the disease.


Subject(s)
Adenoma/diagnostic imaging , Peritoneal Neoplasms/diagnostic imaging , Tomography, X-Ray Computed , Adult , Female , Humans , Male , Middle Aged
4.
Semin Ultrasound CT MR ; 21(1): 2-19, 2000 Feb.
Article in English | MEDLINE | ID: mdl-10688064

ABSTRACT

The use of noncontrast helical CT (NHCT) to assess patients with acute flank pain and hematuria for potential urinary tract stone disease was first reported in 1995. After several years of experience with the technique, sensitivity and specificity of NHCT has proven to be better than intravenous urography for evaluating ureteral stones. NHCT imaging findings for urinary calculi and the differential diagnosis are discussed in this article. Various extraurinary diseases found while using NHCT in searching for stone disease are addressed and illustrated. As experience with the use of NHCT has increased, clinicians have broadened the indications for this technique, which has a lower charge than standard CT, beyond the specific evaluation of urinary colic. This indication creep has increased the number of NHCT examinations ordered. It has also reduced the rate of stone positivity and increased the diagnostic yield for extraurinary disease.


Subject(s)
Abdominal Pain/etiology , Tomography, X-Ray Computed , Urinary Calculi/complications , Urinary Calculi/diagnostic imaging , Algorithms , Diagnosis, Differential , Female , Hematuria/etiology , Humans , Male , Sensitivity and Specificity
5.
AJR Am J Roentgenol ; 174(1): 135-9, 2000 Jan.
Article in English | MEDLINE | ID: mdl-10628469

ABSTRACT

OBJECTIVE: The radiologist and oncologist are often confident that biopsy will confirm their suspicion of recurrent disease, but a biopsy is performed to confirm the histologic diagnosis before beginning or altering therapy. We have examined data to determine how often the biopsied lesion represents recurrent disease from the primary tumor or is an instance of new cancer, and whether recurrent disease can be predicted. MATERIALS AND METHODS: We reviewed the medical and imaging records of 253 patients who underwent CT-guided biopsy of an abdominal or pelvic lesion between 1993 and 1996. Sixty-nine of the 253 patients had a previously diagnosed primary tumor and were being examined for possible tumor recurrence or metastasis. The images of these 69 patients were analyzed to determine if the pattern of disease was typical of recurrence or metastasis. RESULTS: In 55 of the 69 patients, the pattern was judged to be typical of metastatic or recurrent disease. Biopsy confirmed this suspicion in all 55 patients. In 14 of the 69 patients, the pattern of spread was judged not to be typical of recurrence or metastasis. These 14 patients were found to have a new primary tumor (n = 4), benign processes (n = 2), and recurrences (n = 8). CONCLUSION: Of the patients for whom radiographic findings suggested recurrence, we found no patients in whom a new primary tumor would have been missed if biopsy had been avoided. Data should now be acquired prospectively to determine whether it may be prudent to make treatment decisions on the basis of imaging findings alone, without histologic confirmation.


Subject(s)
Abdominal Neoplasms/diagnosis , Biopsy, Needle , Tomography, X-Ray Computed , Abdominal Neoplasms/diagnostic imaging , Abdominal Neoplasms/secondary , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Neoplasm Recurrence, Local/diagnosis , Neoplasm Recurrence, Local/diagnostic imaging , Predictive Value of Tests , Radiography, Abdominal , Retrospective Studies , Sensitivity and Specificity
6.
Crit Rev Diagn Imaging ; 40(2-3): 63-202, 1999 Jun.
Article in English | MEDLINE | ID: mdl-10416103

ABSTRACT

The purpose of this pictorial review is to facilitate recognition and understanding of calcifications seen on conventional radiographs of the abdomen. Calcifications can be categorized by organ system and location in the abdomen. Both common and rare calcifications in the urinary tract, liver, gallbladder, spleen, pancreas, adrenal glands, digestive tract, genital tract, peritoneal cavity, and retroperitoneum are illustrated. Abnormal calcifications in the urinary tract are subcategorized by kidneys, ureters, bladder, and urethra. The density, shape, size, margins, pattern, position, and mobility of calcifications are emphasized for differential diagnoses.


Subject(s)
Calcinosis/diagnostic imaging , Female Urogenital Diseases/diagnostic imaging , Gastrointestinal Diseases/diagnostic imaging , Male Urogenital Diseases , Adrenal Glands/diagnostic imaging , Adrenal Glands/pathology , Adult , Calcification, Physiologic/physiology , Cholecystography , Female , Humans , Male , Middle Aged , Radiography, Abdominal , Spleen/diagnostic imaging , Spleen/pathology , Urography
7.
Biomarkers ; 4(2): 106-17, 1999.
Article in English | MEDLINE | ID: mdl-23885828

ABSTRACT

Women who use the 'hot wire' and 'cool rod' machines to wrap meat in supermarkets are potentially exposed to low levels of benzene and polycyclic aromatic hydrocarbons present in fumes emitted during the thermal decomposition of the plastic used to wrap meat. In order to evaluate whether the benzene metabolite trans, trans-muconic acid (MA) can be used to monitor these low levels, we collected urine samples from supermarket workers, and assayed the urine for MA. Geometric mean after-shift MA levels were highest for subjects who used the 'hot wire' machine, i.e. > 300 ng mg-1 creatinine (Cr). The corresponding levels for subjects who used the 'cool rod' machine were similar to those for subjects who did not use either type of machine, and were much lower. These results indicate that urinary muconic acid has some potential for use in monitoring benzene exposures of less than 1 part per million (ppm). The study detected very high background MA levels (exceeding 2000 ng mg-1 Cr) in some subjects, suggesting that individuals in the general population without occupational exposure to benzene may have urinary MA levels equivalent to exposure to up to 2 ppm benzene in ambient air. However, since non-benzene sources of the metabolite cannot be completely ruled out as partially responsible for these high levels, the public health significance of this finding is not known at the moment.

8.
J Virol Methods ; 72(1): 9-14, 1998 May.
Article in English | MEDLINE | ID: mdl-9672128

ABSTRACT

In order to generate dimeric recombinant transforming growth factor-beta (TGF-beta) proteins, expensive eucaryotic cell systems, such as CHO cells, are usually used. An alternative represents the expression of such proteins in insects using a baculovirus expression system. In this study, recombinant human activin C protein was expressed in Noctuidae larvae. On SDS-PAGE, the expressed protein has a size of about 15 kD under reducing conditions and of about 20 kD under non-reducing conditions. This suggests that activin C is expressed as a dimer and disulfide bridges can be formed. Compared with expression in eucaryotic cell culture systems, expression in insect larvae presents a rapid and low cost method, without the need for expensive tissue culture scale-ups or special equipment.


Subject(s)
Baculoviridae , Genetic Vectors , Inhibins/biosynthesis , 3T3 Cells , Animals , Bombyx , Cell Line , Gene Expression , Humans , Inhibins/genetics , Larva , Manduca , Mice , Moths , Spodoptera
10.
J Comput Assist Tomogr ; 21(5): 681-5, 1997.
Article in English | MEDLINE | ID: mdl-9294552

ABSTRACT

PURPOSE: Our goal was to analyze those factors contributing to the error rate in the interpretation of abdominal CT scans at an academic medical center. METHOD: From a total of 694 consecutive patients (329 male, 365 female), we evaluated the error rates of interpreting abdominal CT studies. The average patient age was 54 years. All abdominal CT studies were reviewed by three to five CT faculty radiologists on the morning after the studies were performed. The error rate was correlated with reader variability, the number of cases read per day, the presence of a resident, inpatient versus outpatient, organ systems, etc. The chi 2-test was used for statistical analysis. RESULTS: A total of 56 errors were found in the reports of 53 patients (overall error rate = 7.6%). Of these errors, 19 were judged to be clinically significant and 7 affected patient management. A statistically significant difference in error rates was noted among the five faculty radiologists (3.6-16.1%, p = 0.00062). No significant correlates between error rates and any of the other variables could be established. CONCLUSION: The primary determinant of error rates in body CT is the skill of the interpreting radiologist.


Subject(s)
Diagnostic Errors , Radiography, Abdominal , Tomography, X-Ray Computed , Abdomen/blood supply , Academic Medical Centers , Adolescent , Adult , Aged , Aged, 80 and over , Ambulatory Care , Angiography , Bone and Bones/diagnostic imaging , Chi-Square Distribution , Clinical Competence , Diagnostic Errors/statistics & numerical data , Evaluation Studies as Topic , Faculty, Medical , Female , Hospitalization , Humans , Internship and Residency , Liver/diagnostic imaging , Male , Middle Aged , Muscles/diagnostic imaging , Observer Variation , Patient Care Planning , Radiographic Image Enhancement/methods , Radiology , Spleen/diagnostic imaging , Tomography, X-Ray Computed/methods , Tomography, X-Ray Computed/statistics & numerical data
11.
Urol Clin North Am ; 24(3): 507-22, 1997 Aug.
Article in English | MEDLINE | ID: mdl-9275976

ABSTRACT

Current imaging techniques, especially CT and MR imaging, make accurate preoperative staging of renal cell carcinoma possible. Because surgery provides the only effective therapy and because survival depends on local and distant extent, precise staging is critical for preoperative planning and prognosis. This article reviews the advantages, limitations, accuracy, and pitfalls of each of the imaging approaches to staging renal cell carcinoma, concentrating on CT and MR imaging. This information then is summarized in a suggested overall approach to staging renal cell carcinoma.


Subject(s)
Carcinoma, Renal Cell/pathology , Kidney Neoplasms/pathology , Magnetic Resonance Imaging , Neoplasm Staging/methods , Tomography, X-Ray Computed , Carcinoma, Renal Cell/diagnosis , Carcinoma, Renal Cell/diagnostic imaging , Humans , Kidney/diagnostic imaging , Kidney/pathology , Kidney Neoplasms/diagnosis , Kidney Neoplasms/diagnostic imaging
12.
Semin Ultrasound CT MR ; 18(2): 91-9, 1997 Apr.
Article in English | MEDLINE | ID: mdl-9163828

ABSTRACT

Numerous surgical options are available to physicians treating patients with renal adenocarcinoma. In the current clinical setting, imaging plays a key role in determining which options are selected. Newer imaging techniques such as helical CT with CT angiography, MRI, and ultrasound (US) have improved staging capabilities in this patient population. However, to approach staging accuracies recently reported, attention must be paid to proper imaging parameters. This article describes the strengths, limitations, and proper techniques used for staging renal adenocarcinoma with CT, MRI, and US.


Subject(s)
Adenocarcinoma/pathology , Carcinoma, Renal Cell/pathology , Diagnostic Imaging , Humans , Kidney Neoplasms , Magnetic Resonance Imaging/methods , Neoplasm Staging , Tomography/methods , Tomography, X-Ray Computed/methods
13.
J Surg Oncol ; 64(4): 312-7, 1997 Apr.
Article in English | MEDLINE | ID: mdl-9142189

ABSTRACT

BACKGROUND: The preoperative assessment of depth of invasion of rectal carcinoma is increasingly important as new treatment methodologies are developed. Accuracy of preoperative endorectal MR imaging was therefore compared with that of the endoscopic rectal sonography in determining depth of invasion of rectal carcinomas. METHOD: From March 1993 to April 1994, 10 consecutive patients with biopsy-proven rectal carcinomas were imaged with both endorectal MR imaging and endoscopic rectal sonography. These two studies were performed an average of 2.7 days apart in each patient. All 10 patients had surgical resection of the rectal carcinoma within days of imaging studies. TNM staging of each malignant lesion was correlated with the imaging reports. RESULT: Staging accuracy was 80% for endorectal MR imaging and 70% for endoscopic rectal sonography. With MR imaging, one T2 lesion was overstaged and one T3 lesion was understaged. With sonography, two T2 lesions were overstaged and one T3 lesion was understaged. One MR error resulted from misinterpretation. All other staging errors occurred in patients with tumor spread into, but not through, the muscularis propria or with microscopic spread through this layer. CONCLUSIONS: Endorectal MR imaging and endoscopic rectal sonography have similar accuracy for assessing depth of invasion of rectal carcinoma.


Subject(s)
Endosonography/methods , Magnetic Resonance Imaging , Rectal Neoplasms/pathology , Rectum/diagnostic imaging , Humans , Neoplasm Invasiveness , Rectal Neoplasms/diagnostic imaging
14.
J Gerontol A Biol Sci Med Sci ; 52(1): B10-9, 1997 Jan.
Article in English | MEDLINE | ID: mdl-9008653

ABSTRACT

Caloric restriction has been demonstrated to retard aging processes and extend maximal life span in rodents, and is currently being evaluated in several nonhuman primate trials. We initiated a study in 32 adult cynomolgus monkeys to evaluate the effect of caloric restriction on parameters contributing to atherosclerosis extent. Following pretrial determinations, at which time a baseline measure of ad libitum (ad lib) dietary intake was assessed, animals were randomized to an ad lib fed group (control) or a caloric restriction group (30% reduction from baseline intake). The animals are being evaluated for glycated proteins, insulin, glucose, insulin sensitivity measures, and specific measures of body fat composition by CT scans (e.g., intra-abdominal fat) over specified intervals. The results from the first year of observation demonstrate a significant diet effect on body weight, and specifically intra-abdominal fat. Further, insulin sensitivity has been significantly increased after 1 year of caloric restriction compared to the ad lib fed group. These studies indicate that caloric restriction has a marked effect on a pathologic fat depot, and this change is associated significantly with an improvement in peripheral tissue insulin sensitivity.


Subject(s)
Aging/physiology , Cardiovascular Physiological Phenomena , Energy Intake , Animals , Body Composition , Body Weight , Carbohydrate Metabolism , Lipids/blood , Macaca fascicularis , Male
16.
Radiographics ; 16(4): 841-54, 1996 Jul.
Article in English | MEDLINE | ID: mdl-8835975

ABSTRACT

The perirenal space may be involved by disease processes that arise within or outside the perirenal space. Key anatomic details that dictate the features of perirenal processes include the renal capsule, the perirenal septa, the renal fascia, and the conic shape and inferomedial orientation of the perirenal space. Superiorly, the perirenal space is open to the bare area of the liver. The perirenal spaces communicate with one another at the level of the lower lumbar vertebrae. The hallmark of perirenal infection is localized or diffuse gas. Chronic urinoma appears as an encapsulated cystic mass, often aligned parallel with the perirenal space. Fat within an apparent spontaneous hematoma of the perirenal space suggests angiomyolipoma. Renal cell carcinoma, lymphoma, and melanoma are the most common causes of discrete solid masses in the perirenal space; metastases occur due to the characteristic lymphatic and vascular supply of the space. Amyloidosis and fibrosis create a nonspecific rind of soft tissue around the kidneys. Diaphragmatic pseudotumor produces a linear "lesion" in the perirenal space.


Subject(s)
Kidney Diseases/diagnostic imaging , Kidney/anatomy & histology , Kidney/diagnostic imaging , Retroperitoneal Space/anatomy & histology , Retroperitoneal Space/diagnostic imaging , Amyloidosis/diagnostic imaging , Hematoma/diagnostic imaging , Humans , Kidney/pathology , Kidney Diseases/pathology , Kidney Neoplasms/diagnostic imaging , Retroperitoneal Fibrosis/diagnostic imaging , Retroperitoneal Space/pathology , Tomography, X-Ray Computed , Urine
17.
Semin Roentgenol ; 31(2): 142-53, 1996 Apr.
Article in English | MEDLINE | ID: mdl-8848730

ABSTRACT

Knowledge of the extent of primary colorectal carcinoma at initial diagnosis is critical for proper management of disease. Currently, CT does not have a role in screening for colorectal carcinoma, though promising work on virtual colonoscopy is on the horizon. In patients with proven colorectal carcinoma, accurate prospective noninvasive assessment can identify those who may benefit from preoperative local radiotherapy, hepatic resection or cryoablation, or intra-arterial chemotherapy. CT should be considered complementary to the clinical assessment of colorectal carcinoma and to other modalities, such as barium enema, endorectal ultrasonography, MRI, and immunoscintigraphy. Although limited in evaluation of the primary tumor and local spread, CT has proven useful in assessing patients thought to harbor extensive local or metastatic disease. CT is generally the modality of choice for imaging the postoperative patient. The cross-sectional display of CT clearly depicts the operative bed, particularly after abdominoperineal resection. Baseline examinations should be obtained 2 to 4 months after surgery, with follow-up examinations every 6 to 9 months for 2 years, and yearly studies thereafter. CT-guided biopsies should be performed when findings suggest recurrent carcinoma.


Subject(s)
Colorectal Neoplasms/diagnostic imaging , Tomography, X-Ray Computed , Colon/diagnostic imaging , Colon/pathology , Colorectal Neoplasms/pathology , Humans , Neoplasm Staging , Postoperative Care , Preoperative Care , Rectum/diagnostic imaging , Rectum/pathology
18.
Growth Factors ; 13(1-2): 65-74, 1996.
Article in English | MEDLINE | ID: mdl-8962721

ABSTRACT

We have expressed and biologically characterized recombinant human growth/differentiation factor 5 (huGDF5). This protein is composed of a mature homodimer consisting of 15 kD subunits. Using recombinant expressed protein, we have demonstrated that huGDF5 in vitro stimulated mesenchyme aggregation and chondrogenesis in rat limb bud cells. In vivo, partially purified huGDF5 induced cartilage and bone formation in muscular tissues of rodents. However, in contrast to the effects of other BMPs, as for example BMP-2, the osteoblastic MC3T3-E1 cells did not respond to huGDF5 as measured by alkaline phosphatase activity. These results suggest that the action of GDF5 may be relatively specific for chondrogenesis during the entire process of the endochondral bone formation. GDF5 may control the morphogenesis of cartilaginous tissue, including joints, in the skeletal development of limbs.


Subject(s)
Bone Morphogenetic Proteins , Growth Substances/pharmacology , Mesoderm/metabolism , Osteogenesis/genetics , Recombinant Proteins/pharmacology , Alkaline Phosphatase/metabolism , Animals , Blotting, Western , Bone and Bones/cytology , Bone and Bones/drug effects , Cartilage/metabolism , Cell Differentiation/genetics , Cells, Cultured , Gene Expression Regulation, Developmental/genetics , Glycosaminoglycans/metabolism , Growth Differentiation Factor 5 , Histocytochemistry , Humans , Mice , Morphogenesis/genetics , Osteogenesis/drug effects , Rats , Vaccinia virus/metabolism
19.
Radiographics ; 15(5): 1069-85; discussion 1086-8, 1995 Sep.
Article in English | MEDLINE | ID: mdl-7501851

ABSTRACT

The urographic nephrogram is an important indicator of underlying functional and structural renal disease. With expansions in use of cross-sectional imaging, the computed tomographic (CT) nephrogram (ie, contrast material enhancement within the renal parenchyma) has assumed a greater role in the evaluation of urinary tract disorders. Both quantitative and qualitative nephrographic abnormalities are well demonstrated by CT, including global or segmental absence or persistence of the nephrogram, slowed temporal progression, striated pattern, and rim pattern. Global absence is nearly always unilateral and is most often seen with blunt abdominal trauma with renal pedicle injury. Segmental absence is attributable to focal renal infarction, most likely due to arterial emboli. Global persistence, which is much more common than segmental persistence, may be unilateral (caused by renal artery stenosis, renal vein thrombosis, or urinary tract obstruction) or bilateral (due to systemic hypotension, intratubular obstruction, or abnormalities in tubular function). Striated nephrograms may be unilateral or bilateral and are caused by ureteric obstruction, acute pyelonephritis, contusion, renal vein thrombosis, tubular obstruction, hypotension, and autosomal recessive polycystic kidney disease. The rim pattern is most often associated with renal infarction and occasionally with acute tubular necrosis and renal vein thrombosis. Careful evaluation of the CT nephrogram is an integral part of the abdominal CT examination.


Subject(s)
Kidney Diseases/diagnostic imaging , Kidney/diagnostic imaging , Tomography, X-Ray Computed , Contrast Media , Humans , Kidney/pathology , Kidney Diseases/pathology
20.
Radiology ; 195(3): 757-62, 1995 Jun.
Article in English | MEDLINE | ID: mdl-7754007

ABSTRACT

PURPOSE: To describe the computed tomographic (CT) appearance of nodular hepatosplenic sarcoidosis and its association with stage with chest radiography and clinical status. MATERIALS AND METHODS: Thirty-two patients (21 women, 11 men; aged 25-68 years) with nodular hepatosplenic sarcoidosis were evaluated. CT findings were described along with chest radiographic stage, clinical status, and level of angiotensin-converting enzyme (ACE). RESULTS: Nodules were small, multiple, and of low attenuation. Organomegaly was common. Abdominal adenopathy was present in 76% of the patients. Chest radiographs were normal in 25%; 61% had stage 1 or 2 radiographs. Abdominal or systemic symptoms were present in 66%. ACE level was elevated in 10 (91%) of 11 patients tested. No change in chest radiographic stage was noted in 74% of patients with follow-up radiographs. CONCLUSION: Nodular hepatosplenic sarcoidosis is associated with organomegaly, adenopathy, and symptoms. Nodules were not associated with advanced lung disease and did not herald a change in chest radiographic stage. An elevated ACE level may be helpful in diagnosis.


Subject(s)
Liver Diseases/diagnostic imaging , Sarcoidosis/diagnostic imaging , Splenic Diseases/diagnostic imaging , Adult , Aged , Female , Humans , Liver Diseases/enzymology , Male , Middle Aged , Peptidyl-Dipeptidase A/blood , Radiography, Thoracic , Sarcoidosis/enzymology , Splenic Diseases/enzymology , Tomography, X-Ray Computed
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