ABSTRACT
A patient with hypercalcemia, hypophosphatemia, and an undifferentiated lymphoma involving only the bone marrow was treated by us. The finding of an elevated serum parathyroid hormone (PTH) level in the presence of normal parathyroid glands and increased metabolic bone activity on bone biopsy suggests an ectopic PTH syndrome. To our knowledge, no previous case of ectopic PTH syndrome associated with a lymphoma with bone marrow involvement only has been reported.
Subject(s)
Hormones, Ectopic/biosynthesis , Lymphoma/metabolism , Paraneoplastic Endocrine Syndromes/metabolism , Parathyroid Hormone/biosynthesis , Bone Marrow/pathology , Female , Humans , Lymphoma/pathology , Middle Aged , Parathyroid Hormone/bloodABSTRACT
Following infusion of parathyroid extract (PTE), parathyroid hormone (PTH) did not cross the placenta from the monkey mother to her fetus. Although maternal PTH levels increased four- to 12-fold, fetal PTH levels remained at the base line at all times tested. To determine if PTH crossed the placenta from fetus to mother, PTE was infused into the fetal aorta while the monkey baby remained in utero. PTH in the fetal serum increased ten-fold without a significant change in maternal serum PTH. Thus, PTH does not cross the placenta in either direction. Blood ionized calcium levels in nonpregnant female monkeys, following infusions of ethylenediaminetetra-acetate (EDTA) were shown to decrease, with a subsequent increase in blood PTH levels. Thus, the monkey arathyroid gland was shown to be physiologically responsive to lowered calcium levels. Biological half-life disappearance times of beef PTH in monkey fetuses and their mothers were similar to those found in human beings.
Subject(s)
Parathyroid Hormone/physiology , Placenta/metabolism , Animals , Calcium/blood , Edetic Acid/pharmacology , Female , Half-Life , Haplorhini , Macaca mulatta , Parathyroid Hormone/metabolism , Pregnancy , Radioimmunoassay , Tissue Extracts/pharmacologySubject(s)
Encephalitis, St. Louis/complications , Thyroiditis/etiology , Adult , Disease Outbreaks , Female , Humans , Thyroiditis/microbiologyABSTRACT
We report the surgical-pathologic findings in 15 adults who had a history of irradiation of the head and neck in childhood. These patients we selected for thyroid surgery because of a "cold" area or areas detected on 99mTc thyroid scan, with or without palpable thyroid abnormalities. Eight of the fifteen patients had thyroid cancer, and 3 had atypical adenomas. We found multiple lesions in 12 patients. Macroscopic and microscopic malignancy in a location different from the cold area or areas occurred in 5 of the 8 cancer patients. In vitro of these findings, we recommend that adults who received irradiation to the head and neck in childhood and who have been found to have an abnormal thyroid scan or thyroid examination, or both, have a total thyroidectomy...
Subject(s)
Adenoma/etiology , Neoplasms, Radiation-Induced , Radiotherapy/adverse effects , Thyroid Neoplasms/etiology , Adenoma/diagnosis , Adenoma/surgery , Adult , Age Factors , Child , Child, Preschool , Chronic Disease , Female , Head/radiation effects , Humans , Infant , Male , Neck/radiation effects , Radiation Effects , Radionuclide Imaging , Radiotherapy Dosage , Thyroid Neoplasms/diagnosis , Thyroid Neoplasms/surgery , Thyroidectomy , Time Factors , Tonsillitis/radiotherapySubject(s)
Adenocarcinoma/complications , Adenoma/complications , Neoplasms, Radiation-Induced , Palatine Tonsil/radiation effects , Parotid Neoplasms/complications , Thyroid Neoplasms/complications , Adult , Age Factors , Child , Humans , Male , Parotid Neoplasms/etiology , Radiation Effects , Thyroid Neoplasms/etiology , Time FactorsSubject(s)
Fetus/metabolism , Parathyroid Hormone/metabolism , Animals , DNA/metabolism , Female , Insulin/metabolism , Intestinal Mucosa/metabolism , Iodine Radioisotopes , Kidney/metabolism , Liver/metabolism , Muscles/metabolism , Organ Specificity , Pregnancy , Radioimmunoassay , Rats , Time FactorsSubject(s)
Multiple Sclerosis/drug therapy , Phosphates/therapeutic use , Reflex, Pupillary , Scotoma/drug therapy , Vision Disorders/drug therapy , Administration, Oral , Humans , Multiple Sclerosis/complications , Phosphates/administration & dosage , Potassium/therapeutic use , Reflex, Abnormal/drug therapy , Reflex, Abnormal/etiology , Scotoma/etiology , Sodium/therapeutic use , Time Factors , Vision Disorders/etiology , Visual Acuity , Visual FieldsSubject(s)
Acute Kidney Injury/complications , Ergocalciferols/therapeutic use , Hypercalcemia/etiology , Hypoparathyroidism/complications , Acute Kidney Injury/physiopathology , Adult , Ergocalciferols/pharmacology , Female , Humans , Hypercalcemia/metabolism , Hypercalcemia/physiopathology , Hypoparathyroidism/drug therapy , Kidney Function Tests , Vitamin D/metabolismSubject(s)
Bone Neoplasms/diagnosis , Carcinoma, Squamous Cell/diagnosis , Carcinoma/diagnosis , Radionuclide Imaging , Autopsy , Biopsy, Needle , Bone Neoplasms/pathology , Carcinoma/pathology , Carcinoma, Squamous Cell/pathology , Diagnostic Errors , False Negative Reactions , Fluorides , Humans , Hypercalcemia/diagnosis , Lung/diagnostic imaging , Male , Middle Aged , Neoplasm Metastasis , Radiography , Radioisotopes , SpineSubject(s)
Hyperparathyroidism/pathology , Biopsy , Bone and Bones/pathology , Humans , Methods , NeedlesSubject(s)
Acute Kidney Injury/complications , Hyperparathyroidism, Secondary/etiology , Acute Kidney Injury/physiopathology , Adolescent , Adult , Aged , Female , Humans , Hypocalcemia/etiology , Male , Middle Aged , Parathyroid Glands/physiopathology , Parathyroid Hormone/metabolism , RadioimmunoassayABSTRACT
The effects of procedures believed to produce a decrease in serum ionized calcium were tested on visual and oculomotor function in nine multiple sclerosis (MS) patients. Transient improvement in scotomas, nystagmus, and oculomotor paresis occurred with intravenous infusions of NaHCO(3) or Na(2)EDTA. Hyperventilation was also tested for its effect on nystagmus and caused marked decreases in frequency. Control experiments with saline infusions did not produce any effect. The probable mechanism and site of action for these effects is discussed. This study demonstrates that certain signs and symptoms in MS can be altered favourably by changes in the internal chemical environment and offers a new approach to the search for a symptomatic therapy in MS.
