[Changes of functional activity of peripheral blood leukocytes during the immunotherapy of tick-borne infections in children].

We studied the peculiarities of functional activity of peripheral blood leukocytes in different etiological variants and clinical forms of tick-borne infections in 629 children aged from 1 to 14 years. The decrease of biocide potential of neutrophils was accompanied by most severe clinical manifestations. The analysis of changes in defensin levels in different clinical forms of tick-borne infections revealed the most significant changes in cases of mixed infection. The dynamics of functional activity of leukocytes during the cycloferon immunotherapy reflected the effectiveness of recovering process in biocide potential regardless of the infection etiology. The main advantage of immunotherapy is the possibility of its use in the complex treatment before the serologic confirmation of the diagnosis regardless of disease etiology.

[The cytokine profile in the acute period of tick-borne neuroinfections in children].

Clinical peculiarities and blood levels of several cytokines were studied in 199 children, aged from 1 to 15 years, in the acute period of different tick-borne infections. The mixed infection manifested itself by the more severe progression of general clinical presentations compared to monoinfections. Etiologically unspecific changes of blood concentrations of cytokines in the acute period of the disease were found. These data were associated with different clinical forms of tick-borne infections. The decrease in the interferon gamma production was associated with the most severe disease progression with focal nervous system disorders. The use of cycloferon as immune modulator in the complex therapy led to the increase in the interferon gamma level and the decrease of general clinical manifestations during tick-borne encephalitis and mixed infection.