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Emerg Infect Dis ; 23(9): 1577-1580, 2017 09.
Article in English | MEDLINE | ID: mdl-28665268

ABSTRACT

Because of the global spread of Zika virus, accurate and high-throughput diagnostic immunoassays are needed. We compared the sensitivity and specificity of 5 commercially available Zika virus serologic assays to the recommended protocol of Zika virus IgM-capture ELISA and plaque-reduction neutralization tests. Most commercial immunoassays showed low sensitivity, which can be increased.


Subject(s)
Immunoassay/methods , Zika Virus Infection/virology , Zika Virus/isolation & purification , Antibodies, Viral/analysis , Antibodies, Viral/immunology , Enzyme-Linked Immunosorbent Assay/methods , Humans , Immunoglobulin G/analysis , Immunoglobulin G/immunology , Immunoglobulin M/analysis , Immunoglobulin M/immunology , Neutralization Tests/methods , Sensitivity and Specificity , Zika Virus/immunology , Zika Virus Infection/diagnosis
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