Application of 4MATRIX and PRF in the Treatment of Infrabone Defects in Chronic Periodontopathy.

BACKGROUND: Periodontal disease also called gum disease is a serious gum infection that damages the soft tissue and, without treatment, can destroy the bone and result in different types of alveolar bone defects. That means that periodontal pockets are present and registered only in case of periodontal disease. OBJECTIVE: The aim of this study is to observe the effect of 4MATRIX and PRF application in the treatment of infrabone defect over case report. MATERIAL AND METHODS: By using regenerative surgical periodontal therapy 4MATRIX bone substituent with 4MATRIX and PRF for elimination of deep pockets or periodontal disease was performed among patient at selected sites. CASE REPORT: The patient's periodontal condition has followed 3, 6- and 9-month period. The patient's oral health-related quality of life showed a marked improvement after periodontal surgery therapy. CONCLUSION: Additional application of PRF and 4MATRIX in conventional surgical treatment of infrabone defects showed decreased values of PPD and CAL registered in the segment treated after 9 months of treatment.

Oral Lichen Planus - Related Connection with HLA-System Antigens.

AIM: To determine whether there is an immunogenic connection and antigen difference between the HLA antigens in the erosive (EOLP) and reticular (ROLP) oral lichen planus. MATERIALS AND METHOD: 73 patients with ROLP and EOLP have been tested. Typing of the HLA antigens has been made for locus A and B. The typing of the HLA was conducted with the use of microlymphocyto toxic test by Terasaki. The reading of the findings has been conducted with an inverse microscope. When a reaction has 4 points it is considered to be positive. RESULTS: The most frequently typified antigens in ROLP from locus A are HLA А2 (57.57%) and А3 (33.33)%, and for locus B 21.21%. In EOLP it is А9 (8888%). In locus B a connection has been found with HLA B8 (77.77%). The statistical analysis with the ×2 test has shown that the carriers of HLA A9 display a relative risk (RR) of 3.65 and ×2=20.72. Consequently, there is high static importance for locus A p<0,001. For locus B, In EOLP for HLA B8, RR=6. 7 ×2=37.64 and p<0,001. ROLP has shown association with HLA A3, where RR=2. 31 and ×2 =9.14 and p<0.05. CONCLUSIONS: In ROLP A3 antigen and in EOLP A9 and A8 may be considered as carriers with proneness to OLP.